Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8

Journal of Magnetic Resonance - Tập 213 - Trang 187-191 - 2011
Karlos X. Moreno1, Crystal Harrison1, A. Dean Sherry1,2,3, Craig R. Malloy1,2,4,5, Matthew E. Merritt1,2,6
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8568, United States
2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8568, United States
3Department of Chemistry, The University of Texas at Dallas, Richardson, TX 75080-3021, United States
4Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8568, United States
5VA North Texas Healthcare System, Dallas, TX 75216-7167, United States
6Molecular Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390-8568, United States

Tài liệu tham khảo

London, 1988, 13C labeling in studies of metabolic regulation, Prog. NMR Spectrosc., 20, 337, 10.1016/0079-6565(88)80010-4 Ardenkjaer-Larsen, 2003, Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR, Proc. Natl. Acad. Sci. U. S. A., 100, 10158, 10.1073/pnas.1733835100 Albers, 2008, Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading, Cancer Res., 68, 8607, 10.1158/0008-5472.CAN-08-0749 Bowen, 2008, Time-resolved dynamic nuclear polarization enhanced NMR spectroscopy13, Angew. Chem., Int. Ed., 47, 5235, 10.1002/anie.200801492 Chen, 2007, Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T–initial experience, Mag. Reson. Med., 58, 1099, 10.1002/mrm.21256 Larson, 2010, Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI, Magn. Reson. Med., 63, 582, 10.1002/mrm.22264 Schroeder, 2009, Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy, FASEB J., 23, 2529, 10.1096/fj.09-129171 Schroeder, 2008, In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance, Proc. Natl. Acad. Sci. U. S. A., 105, 12051, 10.1073/pnas.0805953105 Zierhut, 2010, Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice, J. Magn. Reson., 202, 85, 10.1016/j.jmr.2009.10.003 Day, 2007, Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy, Nat. Med., 13, 1382, 10.1038/nm1650 Gallagher, 2008, 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine, Magn. Reson. Med., 60, 253, 10.1002/mrm.21650 Golman, 2006, Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis, Cancer Res., 66, 10855, 10.1158/0008-5472.CAN-06-2564 Kadkhodie, 1990, Broadband homonuclear cross polarization using flip-flop spectroscopy, J. Magn. Reson., 91, 437 Bennett, 2003, Broadband C-13–C-13 adiabatic mixing in solution optimized for high fields, J. Magn. Reson., 165, 59, 10.1016/S1090-7807(03)00244-1 Badar-Goffer, 1990, Cerebral metabolism of acetate and glucose studied by carbon-13 NMR spectroscopy. A technique for investigating metabolic compartmentation in the brain, Biochem. J., 266, 133, 10.1042/bj2660133 Mohebbi, 1991, Improvements in carbon-13 broadband homonuclear cross-polarization for 2D and 3D NMR, Chem. Phys. Lett., 178, 374, 10.1016/0009-2614(91)90268-E Rucker, 1989, Broadband homonuclear cross polarization in 2D N.M.R. using DIPSI-2, Mol. Phys., 68, 509, 10.1080/00268978900102331 Levitt, 1981, Broadband heteronuclear decoupling, J. Magn. Reson., 47, 328 Sherry, 2004, Analytical solutions for 13C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesis, Metab. Eng., 6, 12, 10.1016/j.ymben.2003.10.007 Hogben, 2011, Spinach – a software library for simulation of spin dynamics in large spin systems, J. Magn. Reson., 208, 179, 10.1016/j.jmr.2010.11.008