Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Immunity - Tập 52 Số 5 - Trang 767-781.e6 - 2020
Chun Zhou1, Xia Chen2,1, Rosa Planells‐Cases3, Jiachen Chu4, Li Wang1, Limin Cao1, Zhihong Li5,6, Karen I. López‐Cayuqueo3, Yadong Xie1, Shiwei Ye7, Wang Xiang8, Florian Ullrich3, Shixin Ma1, Yiyuan Fang8, Xiaoming Zhang8, Zhikang Qian8, Xiaozheng Liang8, Shi Cai7, Zhengfan Jiang9, Dongming Zhou8, Qibin Leng10, Tsan Sam Xiao11, Ke Lan12, Jing Wang2, Huabin Li13, Chao Peng5,6, Zhaozhu Qiu4, Thomas J. Jentsch3,14, Hui Xiao1
1The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2College of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China
3Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin, D-13125 Berlin, Germany
4Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China
6Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 201204, China
7Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
8CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
9Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Peking-Tsinghua Center for Life Sciences, Beijing 100871, China
10Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong 510180, China
11Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
12State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
13Center for Allergic and Inflammatory Diseases & Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, China
14NeuroCure Cluster of Excellence, Charité University Medicine, D-10117 Berlin, Germany

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Immunity

Tập 52 Số 5

767-781.e6

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