Kích thích dây thần kinh qua da (TENS) tăng tốc quá trình lành vết thương ngoài da và ức chế các cytokine gây viêm

Inflammation - Tập 37 - Trang 775-784 - 2013
Seren Gülşen Gürgen1, Oya Sayın2, Ferihan Çetin3, Ayşe Tuç Yücel4
1Department of Histology and Embryology, School of Vocational Health Service, Celal Bayar University, Manisa, Turkey
2Research Laboratory, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey
3Department of Physiology, Faculty of Medicine, İzmir University, Üçkuyular, Turkey
4Department of Anatomy, School of Vocational Health Service, Celal Bayar University, Manisa, Turkey

Tóm tắt

Mục đích của nghiên cứu này là đánh giá kích thích dây thần kinh qua da (TENS) và các phương pháp điều trị phổ biến khác được sử dụng trong quá trình lành vết thương, dựa trên mức độ biểu hiện của các cytokine gây viêm. Trong nghiên cứu, 24 con chuột Wistar–Albino trưởng thành (24 con cái và 24 con đực) được chia thành năm nhóm: (1) nhóm không bị thương không có vết mổ, (2) nhóm đối chứng có vết mổ, (3) nhóm TENS (2 Hz, 15 phút), (4) nhóm dung dịch muối sinh lý (PS) và (5) nhóm iod povidon (PI). Trong các mẫu da, interleukin-1 beta (IL-1β), interleukin-6 (IL-6) và yếu tố hoại tử khối u-α (TNF-α) được đánh giá bằng phương pháp thử nghiệm miễn dịch enzyme liên kết và phương pháp miễn dịch hóa học mô. Trong nhóm không bị thương, sự biểu hiện của các phân tử tín hiệu IL-1β, IL-6 và TNF-α yếu hơn trong toàn bộ mô; tuy nhiên, trong nhóm đối chứng, phản ứng viêm đáng kể đã xảy ra, và sự biểu hiện cytokine mạnh đã được quan sát trong lớp bì, mô hạt, nang lông và tuyến bã (P < 0.05). Trong nhóm TENS, sự giảm phản ứng miễn dịch của TNF-α, IL-1β và IL-6 ở da là đáng kể so với các hình thức điều trị khác (P < 0.05). Những giảm thiểu rõ rệt của các cytokine gây viêm quan sát được trong lớp bì ở nhóm TENS cho thấy TENS đã rút ngắn quá trình lành thương bằng cách ức chế giai đoạn viêm.

Từ khóa

#kích thích dây thần kinh qua da #TENS #lành vết thương #cytokine gây viêm #interleukin #yếu tố hoại tử khối u

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