Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Lancet Microbe, The - Tập 3 - Trang e113-e123 - 2022
Eleonora Vianello1, Patricia Gonzalez-Dias2, Suzanne van Veen1, Carmen G Engele1, Edwin Quinten1, Thomas P Monath3, Donata Medaglini4,5
1Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
2Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
3NewLink Genetics Corporation, Devens, MA, USA
4Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy
5Sclavo Vaccines Association, Siena, Italy

Tài liệu tham khảo

Garbutt, 2004, Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses, J Virol, 78, 5458, 10.1128/JVI.78.10.5458-5465.2004 Geisbert, 2009, Single-injection vaccine protects nonhuman primates against infection with Marburg virus and three species of Ebola virus, J Virol, 83, 7296, 10.1128/JVI.00561-09 Wong, 2014, Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents, Vaccine, 32, 5722, 10.1016/j.vaccine.2014.08.028 Jones, 2007, Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever, J Infect Dis, 196, S404, 10.1086/520591 Marzi, 2019, Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge, EBioMedicine, 49, 223, 10.1016/j.ebiom.2019.09.055 Suder, 2018, The vesicular stomatitis virus-based Ebola virus vaccine: from concept to clinical trials, Hum Vaccin Immunother, 14, 2107, 10.1080/21645515.2018.1473698 Henao-Restrepo, 2017, Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!), Lancet, 389, 505, 10.1016/S0140-6736(16)32621-6 Huttner, 2018, Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?, Expert Rev Vaccines, 17, 1105, 10.1080/14760584.2018.1546582 Huttner, 2017, A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa, Sci Transl Med, 9, 1, 10.1126/scitranslmed.aaj1701 Ehrhardt, 2019, Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV, Nat Med, 25, 1589, 10.1038/s41591-019-0602-4 Dahlke, 2017, Dose-dependent T-cell dynamics and cytokine cascade following rVSV-ZEBOV immunization, EBioMedicine, 19, 107, 10.1016/j.ebiom.2017.03.045 Joosten, 2012, Identification of biomarkers for tuberculosis disease using a novel dual-color RT-MLPA assay, Genes Immun, 13, 71, 10.1038/gene.2011.64 Huttner, 2015, The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial, Lancet Infect Dis, 15, 1156, 10.1016/S1473-3099(15)00154-1 Agnandji, 2016, Phase 1 trials of rVSV Ebola vaccine in Africa and Europe, N Engl J Med, 374, 1647, 10.1056/NEJMoa1502924 Heppner, 2017, Safety and immunogenicity of the rVSVΔG-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study, Lancet Infect Dis, 17, 854, 10.1016/S1473-3099(17)30313-4 Menicucci, 2019, Antiviral innate responses induced by VSV-EBOV vaccination contribute to rapid protection, MBio, 10, 1, 10.1128/mBio.00597-19 Rechtien, 2017, Systems vaccinology identifies an early innate immune signature as a correlate of antibody responses to the Ebola vaccine rVSV-ZEBOV, Cell Rep, 20, 2251, 10.1016/j.celrep.2017.08.023 Pulendran, 2013, Immunity to viruses: learning from successful human vaccines, Immunol Rev, 255, 243, 10.1111/imr.12099 Schoggins, 2011, Interferon-stimulated genes and their antiviral effector functions, Curr Opin Virol, 1, 519, 10.1016/j.coviro.2011.10.008 Huang, 2011, Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus, PLoS Pathog, 7, 10.1371/journal.ppat.1001258 Weidner, 2010, Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms, J Virol, 84, 12646, 10.1128/JVI.01328-10 Pilla-Moffett, 2016, Interferon-inducible GTPases in host resistance, inflammation and disease, J Mol Biol, 428, 3495, 10.1016/j.jmb.2016.04.032 Querec, 2009, Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans, Nat Immunol, 10, 116, 10.1038/ni.1688 Nakaya, 2011, Systems biology of vaccination for seasonal influenza in humans, Nat Immunol, 12, 786, 10.1038/ni.2067 Sokol, 2015, The chemokine system in innate immunity, Cold Spring Harb Perspect Biol, 7, 1, 10.1101/cshperspect.a016303 Pejoski, 2020, Rapid dose-dependent natural killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebola virus vaccination, NPJ Vaccines, 5, 32, 10.1038/s41541-020-0179-4 Marzi, 2013, Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates, Proc Natl Acad Sci USA, 110, 1893, 10.1073/pnas.1209591110 Warfield, 2018, Role of antibodies in protection against Ebola virus in nonhuman primates immunized with three vaccine platforms, J Infect Dis, 218, S553, 10.1093/infdis/jiy316 Wong, 2012, Immune parameters correlate with protection against Ebola virus infection in rodents and nonhuman primates, Sci Transl Med, 4, 10.1126/scitranslmed.3004582 Huttner, 2018, Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study, Lancet Infect Dis, 18, 738, 10.1016/S1473-3099(18)30165-8 Cao, 2014, Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children, J Infect Dis, 210, 224, 10.1093/infdis/jiu079 Kazmin, 2017, Systems analysis of protective immune responses to RTS,S malaria vaccination in humans, Proc Natl Acad Sci USA, 114, 2425, 10.1073/pnas.1621489114 Popper, 2018, Early transcriptional responses after dengue vaccination mirror the response to natural infection and predict neutralizing antibody titers, J Infect Dis, 218, 1911, 10.1093/infdis/jiy434 Haralambieva, 2013, Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination, PLoS One, 8, 10.1371/journal.pone.0062149 Le Bon, 2006, Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN, J Immunol, 176, 2074, 10.4049/jimmunol.176.4.2074 Kuroda, 2020, Identification of interferon-stimulated genes that attenuate Ebola virus infection, Nat Commun, 11, 10.1038/s41467-020-16768-7 Weinberger, 2018, Impaired immune response to primary but not to booster vaccination against hepatitis B in older adults, Front Immunol, 9, 10.3389/fimmu.2018.01035 Panozzo, 2019, Arthritis and arthralgia as an adverse event following immunization: a systematic literature review, Vaccine, 37, 372, 10.1016/j.vaccine.2018.06.067 Lathrop, 2002, Adverse event reports following vaccination for Lyme disease: December 1998–July 2000, Vaccine, 20, 1603, 10.1016/S0264-410X(01)00500-X Pope, 2013, Possible roles of IL-12-family cytokines in rheumatoid arthritis, Nat Rev Rheumatol, 9, 252, 10.1038/nrrheum.2012.170 Zhang, 2005, Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis, Arthritis Rheum, 52, 3839, 10.1002/art.21482 Nam, 2011, Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis, PLoS One, 6, 10.1371/journal.pone.0024320 van Hamburg, 2009, GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis, Arthritis Rheum, 60, 750, 10.1002/art.24329