Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors

Guilliams, 2014, Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny, Nat. Rev. Immunol., 14, 571, 10.1038/nri3712

Allan, 2003, Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells, Science, 301, 1925, 10.1126/science.1087576

Granot, 2017, Dendritic cells display subset and tissue-specific maturation dynamics over human life, Immunity, 46, 504, 10.1016/j.immuni.2017.02.019

Collin, 2018, Human dendritic cell subsets: an update, Immunology, 154, 3, 10.1111/imm.12888

McGovern, 2014, Human dermal CD14(+) cells are a transient population of monocyte-derived macrophages, Immunity, 41, 465, 10.1016/j.immuni.2014.08.006

Chu, 2012, Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation, J. Exp. Med., 209, 935, 10.1084/jem.20112583

Villani, 2017, Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, Science, 356, 10.1126/science.aah4573

Alcantara-Hernandez, 2017, High-dimensional phenotypic mapping of human dendritic cells reveals interindividual variation and tissue specialization, Immunity, 47, 10.1016/j.immuni.2017.11.001

Cochain, 2018, Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis, Circ. Res., 122, 1661, 10.1161/CIRCRESAHA.117.312509

Zong, 2017, Single-cell RNA-seq study determines the ontogeny of macrophages in glioblastomas, Genome Biol., 18, 235, 10.1186/s13059-017-1375-z

Chung, 2017, Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer, Nat. Commun., 8, 15081, 10.1038/ncomms15081

Tabib, 2018, SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin, J. Invest. Dermatol., 138, 802, 10.1016/j.jid.2017.09.045

Haniffa, 2015, Human skin dendritic cells in health and disease, J. Dermatol. Sci., 77, 85, 10.1016/j.jdermsci.2014.08.012

Lenz, 1993, Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization, J. Clin. Invest., 92, 2587, 10.1172/JCI116873

De Monte, 2016, CD1c-related DCs that express CD207/langerin, but are distinguishable from langerhans cells, are consistently present in human tonsils, Front. Immunol., 7, 197, 10.3389/fimmu.2016.00197

Heidkamp, 2016, Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment, Sci. Immunol., 1, 10.1126/sciimmunol.aai7677

Auray, 2016, Characterization and transcriptomic analysis of porcine blood conventional and plasmacytoid dendritic cells reveals striking species-specific differences, J. Immunol., 197, 4791, 10.4049/jimmunol.1600672

Kovtun, 2017, Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair, Sci. Rep., 7, 14061, 10.1038/s41598-017-14444-3

Ebong, 2001, Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality, Infect. Immun., 69, 2099, 10.1128/IAI.69.4.2099-2106.2001

Pauls, 2013, Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice, J. Immunol., 191, 2717, 10.4049/jimmunol.1203268

Guilliams, 2016, Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species, Immunity, 45, 669, 10.1016/j.immuni.2016.08.015

Mizumoto, 2004, CD1a and langerin: acting as more than Langerhans cell markers, J. Clin. Invest., 113, 658, 10.1172/JCI200421140

Ouchi, 2016, EpCAM expressed by murine epidermal langerhans cells modulates immunization to an epicutaneously applied protein antigen, J. Invest. Dermatol., 136, 1627, 10.1016/j.jid.2016.04.005

Zimmerli, 2008, Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome), Exp. Dermatol., 17, 20, 10.1111/j.1600-0625.2007.00624.x

Polak, 2014, Distinct molecular signature of human skin langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation, J. Invest. Dermatol., 134, 695, 10.1038/jid.2013.375

Lenormand, 2012, HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule, J. Immunol., 188, 3903, 10.4049/jimmunol.1103048

Katou, 2003, Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin, J. Pathol., 199, 98, 10.1002/path.1255

Jin, 2010, Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies, J. Transl. Med., 8, 4, 10.1186/1479-5876-8-4

Johansson, 2012, Characterisation and expression analysis of the rainbow trout (Oncorhynchus mykiss) homologue of the human dendritic cell marker CD208/lysosomal associated membrane protein 3, Dev. Comp. Immunol., 37, 402, 10.1016/j.dci.2012.02.012

Bjorklund, 2016, The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing, Nat. Immunol., 17, 451, 10.1038/ni.3368

Kim, 2013, TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation, Sci. Transl. Med., 5, 10.1126/scitranslmed.3005374

Teunissen, 2014, Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients, J. Invest. Dermatol., 134, 2351, 10.1038/jid.2014.146

Niven, 2015, S100B up-regulates macrophage production of IL1beta and CCL22 and influences severity of retinal inflammation, PLoS One, 10, 10.1371/journal.pone.0132688

Saban, 2014, The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation, Ocul. Surf., 12, 87, 10.1016/j.jtos.2013.10.007

Schreibelt, 2012, The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells, Blood, 119, 2284, 10.1182/blood-2011-08-373944

Galibert, 2005, Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule, J. Biol. Chem., 280, 21955, 10.1074/jbc.M502095200

Theisen, 2018, WDFY4 is required for cross-presentation in response to viral and tumor antigens, Science, 362, 694, 10.1126/science.aat5030

Malaguarnera, 2017, Vitamin D3 regulates LAMP3 expression in monocyte derived dendritic cells, Cell. Immunol., 311, 13, 10.1016/j.cellimm.2016.09.013

Oh, 2018, CD40 mediates maturation of thymic dendritic cells driven by self-reactive CD4(+) thymocytes and supports development of natural regulatory T cells, J. Immunol., 200, 1399, 10.4049/jimmunol.1700768

Chinetti-Gbaguidi, 2011, Macrophage polarization in metabolic disorders: functions and regulation, Curr. Opin. Lipidol., 22, 365, 10.1097/MOL.0b013e32834a77b4

Hong, 2016, Cytokines regulate beta-cell thioredoxin-interacting protein (TXNIP) via distinct mechanisms and pathways, J. Biol. Chem., 291, 8428, 10.1074/jbc.M115.698365

Kaufmann, 2001, Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages, J. Leukoc. Biol., 69, 248, 10.1189/jlb.69.2.248

Rouault, 2013, Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue, Endocrinology, 154, 1069, 10.1210/en.2012-1415

Ong, 2012, Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response, Eur. J. Immunol., 42, 89, 10.1002/eji.201141825

Keren-Shaul, 2017, A unique microglia type associated with restricting development of Alzheimer’s disease, Cell, 169, 10.1016/j.cell.2017.05.018

Wang, 2016, TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques, J. Exp. Med., 213, 667, 10.1084/jem.20151948