Transcriptional mechanisms in osteoblast differentiation and bone formation

Erlebacher, 1995, Toward a molecular understanding of skeletal development, Cell, 80, 371, 10.1016/0092-8674(95)90487-5 DeLise, 2000, Cellular interactions and signaling in cartilage development, Osteoarthritis Cartilage, 8, 309, 10.1053/joca.1999.0306 Ornitz, 2002, FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease, Genes Dev., 16, 1446, 10.1101/gad.990702 Ducy, 2000, Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass, Cell, 100, 197, 10.1016/S0092-8674(00)81558-5 Takeda, 2002, Leptin regulates bone formation via the sympathetic nervous system, Cell, 111, 305, 10.1016/S0092-8674(02)01049-8 Mundlos, 1997, Heritable diseases of the skeleton. Part II: Molecular insights into skeletal development-matrix components and their homeostasis, FASEB J., 11, 227, 10.1096/fasebj.11.4.9068611 Ito, 1999, Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF, Genes Cells, 4, 685, 10.1046/j.1365-2443.1999.00298.x Okuda, 1996, AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis, Cell, 84, 321, 10.1016/S0092-8674(00)80986-1 Li, 2002, Causal relationship between the loss of RUNX3 expression and gastric cancer, Cell, 109, 113, 10.1016/S0092-8674(02)00690-6 Otto, 1997, Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development, Cell, 89, 765, 10.1016/S0092-8674(00)80259-7 Inada, 1999, Maturational disturbance of chondrocytes in Cbfa1-deficient mice, Dev. Dyn., 214, 279, 10.1002/(SICI)1097-0177(199904)214:4<279::AID-AJA1>3.0.CO;2-W Ducy, 1997, Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation, Cell, 89, 747, 10.1016/S0092-8674(00)80257-3 Mundlos, 1997, Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia, Cell, 89, 773, 10.1016/S0092-8674(00)80260-3 Komori, 1997, Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts, Cell, 89, 755, 10.1016/S0092-8674(00)80258-5 Yoshida, 2002, Core-binding factor beta interacts with Runx2 and is required for skeletal development, Nat. Genet., 32, 633, 10.1038/ng1015 Kundu, 2002, Cbfbeta interacts with Runx2 and has a critical role in bone development, Nat. Genet., 32, 639, 10.1038/ng1050 Miller, 2002, The core-binding factor beta subunit is required for bone formation and hematopoietic maturation, Nat. Genet., 32, 645, 10.1038/ng1049 Takeda, 2001, Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice, Genes Dev., 15, 467, 10.1101/gad.845101 Ueta, 2001, Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes, J. Cell Biol., 153, 87, 10.1083/jcb.153.1.87 Liu, 2001, Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures, J. Cell Biol., 155, 157, 10.1083/jcb.200105052 Geoffroy, 2002, High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage, Mol. Cell. Biol., 22, 6222, 10.1128/MCB.22.17.6222-6233.2002 Choi, 2001, Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development, Proc. Natl. Acad. Sci. U. S. A., 98, 8650, 10.1073/pnas.151236498 Zhang, 2000, A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia, Proc. Natl. Acad. Sci. U. S. A., 97, 10549, 10.1073/pnas.180309597 Xiao, 2002, Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2, J. Biol. Chem., 277, 36181, 10.1074/jbc.M206057200 Tintut, 1999, Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation, J. Biol. Chem., 274, 28875, 10.1074/jbc.274.41.28875 Wee, 2002, Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms, EMBO Rep., 3, 967, 10.1093/embo-reports/kvf193 Thirunavukkarasu, 1998, Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta, Mol. Cell. Biol., 18, 4197, 10.1128/MCB.18.7.4197 McLarren, 2000, The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1, J. Biol. Chem., 275, 530, 10.1074/jbc.275.1.530 Thomas, 2001, The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation, Mol. Cell, 8, 303, 10.1016/S1097-2765(01)00327-6 Nakashima, 2002, The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation, Cell, 108, 17, 10.1016/S0092-8674(01)00622-5 Zelzer, 2001, Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2, Mech. Dev., 106, 97, 10.1016/S0925-4773(01)00428-2 Thirunavukkarasu, 2000, The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function, J. Biol. Chem., 275, 25163, 10.1074/jbc.M000322200 Fang, 1997, Chondrogenic cell differentiation from membrane bone periostea, Anat. Embryol. (Berl.), 196, 349, 10.1007/s004290050104 Karsenty, 1999, The genetic transformation of bone biology, Genes Dev., 13, 3037, 10.1101/gad.13.23.3037 Grigoriadis, 1988, Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone, J. Cell Biol., 106, 2139, 10.1083/jcb.106.6.2139 Akiyama, 2002, The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6, Genes Dev., 16, 2813, 10.1101/gad.1017802 Satokata, 1994, Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development, Nat. Genet., 6, 348, 10.1038/ng0494-348 Satokata, 2000, Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation, Nat. Genet., 24, 391, 10.1038/74231 Ma, 1996, The molecular basis of Boston-type craniosynostosis: the Pro148→His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence preferences, Hum. Mol. Genet., 5, 1915, 10.1093/hmg/5.12.1915 Zhao, 1994, rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues, Dev. Biol., 164, 37, 10.1006/dbio.1994.1178 Chen, 1996, Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox genes expressed in the embryonic skeleton, Ann. N. Y. Acad. Sci., 785, 38, 10.1111/j.1749-6632.1996.tb56242.x Simeone, 1994, Cloning and characterization of two members of the vertebrate Dlx gene family, Proc. Natl. Acad. Sci. U. S. A., 91, 2250, 10.1073/pnas.91.6.2250 Depew, 1999, Dlx5 regulates regional development of the branchial arches and sensory capsules, Development, 126, 3831, 10.1242/dev.126.17.3831 Acampora, 1999, Craniofacial, vestibular and bone defects in mice lacking the Distal- less-related gene Dlx5, Development, 126, 3795, 10.1242/dev.126.17.3795 Robledo, 2002, The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development, Genes Dev., 16, 1089, 10.1101/gad.988402 Depew, 2002, Specification of jaw subdivisions by Dlx genes, Science, 298, 381, 10.1126/science.1075703 Miyama, 1999, A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction, Dev. Biol., 208, 123, 10.1006/dbio.1998.9197 Tadic, 2002, Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation, J. Bone Miner. Res., 17, 1008, 10.1359/jbmr.2002.17.6.1008 Li, 1995, Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis, Dev. Biol., 172, 280, 10.1006/dbio.1995.0023 Rice, 2000, Integration of FGF and TWIST in calvarial bone and suture development, Development, 127, 1845, 10.1242/dev.127.9.1845 Chen, 1995, twist is required in head mesenchyme for cranial neural tube morphogenesis, Genes Dev., 9, 686, 10.1101/gad.9.6.686 Howard, 1997, Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome, Nat. Genet., 15, 36, 10.1038/ng0197-36 el Ghouzzi, 1997, Mutations of the TWIST gene in the Saethre-Chotzen syndrome, Nat. Genet., 15, 42, 10.1038/ng0197-42 Bourgeois, 1998, The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome, Hum. Mol. Genet., 7, 945, 10.1093/hmg/7.6.945 Yousfi, 2001, Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome, J. Clin. Invest., 107, 1153, 10.1172/JCI11846 Sabatakos, 2000, Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis, Nat. Med., 6, 985, 10.1038/79683 Jochum, 2000, Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1, Nat. Med., 6, 980, 10.1038/79676 Levi, 1996, Defective bone formation in Krox-20 mutant mice, Development, 122, 113, 10.1242/dev.122.1.113 Bouwman, 2000, Transcription factor Sp3 is essential for post-natal survival and late tooth development, EMBO J., 19, 655, 10.1093/emboj/19.4.655 Gollner, 2001, Impaired ossification in mice lacking the transcription factor Sp3, Mech. Dev., 106, 77, 10.1016/S0925-4773(01)00420-8