Transcriptional and physiological roles for STAT proteins in leptin action

Molecular Metabolism - Tập 22 - Trang 121-131 - 2019
Warren Pan1,2, Margaret B. Allison3,4, Paul Sabatini3, Alan Rupp3, Jessica Adams5, Christa Patterson3, Justin C. Jones3, David P. Olson5, Martin G. Myers3,2
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
2Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA
3Department of Internal Medicine, University of Michigan, Ann Arbor, MI/USA
4Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
5Division of Endocrinology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA

Tài liệu tham khảo

Data and statistics on overweight and obesity. https://www.cdc.gov/obesity/data/adult.html. Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0 Allison, 2014, 20 years of leptin: connecting leptin signaling to biological function, Journal of Endocrinology, 223, T25, 10.1530/JOE-14-0404 Ring, 2010, Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels, Journal of Clinical Investigation, 120, 2931, 10.1172/JCI41985 Tartaglia, 1995, Identification and expression cloning of a leptin receptor, OB-R, Cell, 83, 1263, 10.1016/0092-8674(95)90151-5 Gong, 2007, The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms, Journal of Biological Chemistry, 282, 31019, 10.1074/jbc.M702838200 Banks, 2000, Activation of downstream signals by the long form of the leptin receptor, Journal of Biological Chemistry, 275, 14563, 10.1074/jbc.275.19.14563 Hekerman, 2005, Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines, FEBS Journal, 272, 109, 10.1111/j.1432-1033.2004.04391.x Bjorbaek, 2000, SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985, Journal of Biological Chemistry, 275, 40649, 10.1074/jbc.M007577200 Bjornholm, 2007, Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function, Journal of Clinical Investigation, 117, 1354, 10.1172/JCI30688 Bates, 2003, STAT3 signaling is required for leptin regulation of energy balance but not reproduction, Nature, 421, 856, 10.1038/nature01388 Jiang, 2008, Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis, Proceedings of the National Academy of Sciences, 105, 18619, 10.1073/pnas.0804589105 Vaisse, 1996, Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice, Nature Genetics, 14, 95, 10.1038/ng0996-95 Piper, 2008, Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons, Molecular Endocrinology, 22, 751, 10.1210/me.2007-0389 Lee, 2008, Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity, PLoS One, 3, e1639, 10.1371/journal.pone.0001639 Allison, 2015, TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons, Molecular Metabolism, 4, 299, 10.1016/j.molmet.2015.01.012 Klover, 2010, Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden, Neoplasia, 12, 899, 10.1593/neo.10716 Cui, 2004, Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation, Molecular and Cellular Biology, 24, 8037, 10.1128/MCB.24.18.8037-8047.2004 Mesaros, 2008, Activation of Stat3 signaling in AgRP neurons promotes locomotor activity, Cell Metabolism, 7, 236, 10.1016/j.cmet.2008.01.007 Dobin, 2013, STAR: ultrafast universal RNA-seq aligner, Bioinformatics, 29, 15, 10.1093/bioinformatics/bts635 Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biology, 15, 550, 10.1186/s13059-014-0550-8 Allison, 2018, Defining the transcriptional targets of leptin reveals a role for Atf3 in leptin action, Diabetes, 67, 1093, 10.2337/db17-1395 Caron, 2018, POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels, eLife, 7, 10.7554/eLife.33710 Myers, 2012, Challenges and opportunities of defining clinical leptin resistance, Cell Metabolism, 15, 150, 10.1016/j.cmet.2012.01.002 Baumann, 1996, The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors, Proceedings of the National Academy of Sciences, 93, 8374, 10.1073/pnas.93.16.8374 Gao, 2004, Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation, Proceedings of the National Academy of Sciences, 101, 4661, 10.1073/pnas.0303992101 Piper, 2007, Specific physiological roles for Stat3 in leptin receptor-expressing neurons, Molecular Endocrinology Singireddy, 2013, Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice, Endocrinology, 154, 2434, 10.1210/en.2013-1109 Patterson, 2012 Reed, 2005, GM-CSF action in the CNS decreases food intake and body weight, Journal of Clinical Investigation, 115, 3035, 10.1172/JCI25681 Robertson, 2010, Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions, Diabetes, 59, 782, 10.2337/db09-1556 Niswender, 2001, Intracellular signallingKey enzyme in leptin-induced anorexia, Nature, 413, 794, 10.1038/35101657 Rahmouni, 2009, Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin, Diabetes, 58, 536, 10.2337/db08-0822 Helfer, 2016, Hypothalamic Wnt signalling and its role in energy balance regulation, Journal of Neuroendocrinology, 28, 12368, 10.1111/jne.12368 Ernst, 2009, Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity, Journal of Neuroscience – The Official Journal of the Society for Neuroscience, 29, 11582, 10.1523/JNEUROSCI.5712-08.2009 Rupp, 2018, Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance, Molecular Metabolism, 10.1016/j.molmet.2018.06.001 Bouret, 2012, Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits, Journal of Neuroscience – The Official Journal of the Society for Neuroscience, 32, 1244, 10.1523/JNEUROSCI.2277-11.2012 Satoh, 2013, A comprehensive profile of ChIP-seq-based STAT1 target genes suggests the complexity of STAT1-mediated gene regulatory mechanisms, Gene Regulation and Systems Biology, 7, 41, 10.4137/GRSB.S11433