Transcriptional Suppression of Type 1 Angiotensin II Receptor Gene Expression by Peroxisome Proliferator-Activated Receptor-γ in Vascular Smooth Muscle Cells*

Endocrinology - Tập 142 Số 7 - Trang 3125-3134 - 2001
Akira Sugawara1, Kazuhisa Takeuchi1, Akira Uruno1, Yukio Ikeda1, Shuji Arima1, Masataka Kudo1, Kazunori Sato1, Yoshihiro Taniyama1, Sadayoshi Ito1
1Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan

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Tài liệu tham khảo

Griendling, 1997, Angiotensin II signaling in vascular smooth muscle. New concepts., Hypertension, 29, 366, 10.1161/01.HYP.29.1.366

Berk, 1999, Angiotensin II signal transduction in vascular smooth muscle: pathways activated by specific tyrosine kinases, J Am Soc Nephrol, 10, S62

Paradis, 2000, Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling., Proc Natl Acad Sci USA, 97, 931, 10.1073/pnas.97.2.931

Nataraj, 1999, Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway., J Clin Invest, 104, 1693, 10.1172/JCI7451

Murphy, 1992, Molecular biology of vascular type-1 angiotensin II receptor., Am J Hypertens, 5, 236, 10.1093/ajh/5.12.236S

Timmermans, 1999, Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics, Hypertens Res, 22, 147, 10.1291/hypres.22.147

Takeuchi, 1993, Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene., Circ Res, 73, 612, 10.1161/01.RES.73.4.612

Ikeda, 1999, Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-gamma in vascular smooth muscle cells., Biochem Biophys Res Commun, 262, 494, 10.1006/bbrc.1999.1226

Forman, 1995, 15-Deoxy-Δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR γ., Cell, 83, 803, 10.1016/0092-8674(95)90193-0

Lehmann, 1995, An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ)., J Biol Chem, 270, 12953, 10.1074/jbc.270.22.12953

Juge-Aubry, 1997, DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region., J Biol Chem, 272, 25252, 10.1074/jbc.272.40.25252

Spiegelman, 1998, PPAR-γ: adipogenic regulator and thiazolidinedione receptor., Diabetes, 47, 507, 10.2337/diabetes.47.4.507

Ricote, 1998, The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation., Nature, 391, 79, 10.1038/34178

Jiang, 1998, PPAR-γ agonists inhibit production of monocyte inflammatory cytokines., Nature, 391, 82, 10.1038/34184

Ross, 1999, Atherosclerosis—an inflammatory disease., N Engl J Med, 340, 115, 10.1056/NEJM199901143400207

Marx, 1998, Peroxisome proliferator-activated receptor γ activators inhibit gene expression and migration in human vascular smooth muscle cells., Circ Res, 83, 1097, 10.1161/01.RES.83.11.1097

Iijima, 1998, Expression of peroxisome proliferator-activated receptor γ (PPARγ) in rat aortic smooth muscle cells., Biochem Biophys Res Commun, 247, 353, 10.1006/bbrc.1998.8794

Kliewer, 1994, Differential expression and activation of a family of murine peroxisome proliferator-activated receptors., Proc Natl Acad Sci USA, 91, 7355, 10.1073/pnas.91.15.7355

Mangelsdorf, 1992, Characterization of three RXR genes that mediate the action of 9-cis retinoic acid., Genes Dev, 6, 329, 10.1101/gad.6.3.329

Kobayashi, 1996, Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene., J Biol Chem, 271, 12310, 10.1074/jbc.271.21.12310

Sugawara, 1997, Retinoid X receptors in the kidney: their protein expression and functional significance., Endocrinology, 138, 3175, 10.1210/endo.138.8.5351

Murphy, 1991, Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor., Nature, 351, 233, 10.1038/351233a0

Park, 1997, PPAR-γ gene expression is elevated in skeletal muscle of obese and type II diabetic subjects., Diabetes, 46, 1230, 10.2337/diab.46.7.1230

Takahashi, 1998, Structure and transcriptional function of the 5′-flanking region of rat thromboxane receptor gene., Biochem Biophys Res Commun, 244, 489, 10.1006/bbrc.1998.8283

Wang, 1998, Immunolocalization of subtype 2 angiotensin II (AT2) receptor protein in rat heart., Hypertension, 32, 78, 10.1161/01.HYP.32.1.78

Sugawara, 1995, Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland., Endocrinology, 136, 1766, 10.1210/endo.136.4.7895689

Dynan, 1983, The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter., Cell, 35, 79, 10.1016/0092-8674(83)90210-6

Graf, 1997, Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells., FEBS Lett, 400, 119, 10.1016/S0014-5793(96)01371-3

Goetze, 1999, Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells., FEBS Lett, 452, 277, 10.1016/S0014-5793(99)00624-9

Scheinman, 1995, Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors., Mol Cell Biol, 15, 943, 10.1128/MCB.15.2.943

Ikeda, 2000, Suppression of rat thromboxane synthase gene transcription by peroxiosme proliferator-activated receptor in macrophages via an interaction with NF-E2 related factor 2., J Biol Chem, 275, 33142, 10.1074/jbc.M002319200

Sugawara, 1998, Negative regulation of rat thromboxane receptor gene by 15-deoxy-Δ12, 14-PGJ2 and troglitazone by activating PPAR-γ in vascular smooth muscle cells., J Am Soc Nephrol, 9, 358

Satoh, 1999, Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARγ on vascular endothelial function., Biochem Biophys Res Commun, 254, 757, 10.1006/bbrc.1998.0126

Kato, 1999, Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human endothelial cells: a possible role of PPARγ in endothelial function., Biochem Biophys Res Commun, 258, 431, 10.1006/bbrc.1999.0648

Law, 1996, Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia., J Clin Invest, 98, 1897, 10.1172/JCI118991

Tontonoz, 1998, PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL., Cell, 93, 241, 10.1016/S0092-8674(00)81575-5

Nagy, 1998, Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ., Cell, 93, 229, 10.1016/S0092-8674(00)81574-3

Shinohara, 1998, Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats., Atherosclerosis, 136, 275, 10.1016/S0021-9150(97)00220-7

Ogihara, 1995, Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives., Am J Hypertens, 8, 316, 10.1016/0895-7061(95)96214-5

Imano, 1988, Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy., Diabetes Care, 21, 2135, 10.2337/diacare.21.12.2135

Ghazzi, 1997, Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group., Diabetes, 46, 433, 10.2337/diab.46.3.433