Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice

Bigger, 1984, The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction, Circulation, 69, 250, 10.1161/01.CIR.69.2.250 Aimond, 1999, Ionic basis of ventricular arrhythmias in remodeled rat heart during long-term myocardial infarction, Cardiovasc Res, 42, 402, 10.1016/S0008-6363(99)00070-X Daya, 2020, Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest, Circulation, 141, 188, 10.1161/CIRCULATIONAHA.119.042240 Shy, 2013, Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model, Biochim Biophys Acta, 1833, 886, 10.1016/j.bbamcr.2012.10.026 Liu, 2016, Cardiac Sodium Channel Mutations: Why so Many Phenotypes?, Curr Top Membr, 78, 513, 10.1016/bs.ctm.2015.12.004 Wagner, 2015, Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death, Circ Res, 116, 1956, 10.1161/CIRCRESAHA.116.304678 Pu, 1997, Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness, Circ Res, 81, 110, 10.1161/01.RES.81.1.110 Baba, 2005, Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia, Circulation, 112, 2386, 10.1161/CIRCULATIONAHA.105.534784 Li, 2020, Fibroblast growth factor 21 inhibited ischemic arrhythmias via targeting miR-143/EGR1 axis, Basic Res Cardiol, 115, 10.1007/s00395-019-0768-4 Shang, 2007, Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel, Circ Res, 101, 1146, 10.1161/CIRCRESAHA.107.152918 Veerman, 2015, The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology, Gene, 573, 177, 10.1016/j.gene.2015.08.062 Roychoudhury J, Clark JP, Gracia-Maldonado G, Unnisa Z, Wunderlich M, Link KA, et al. MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood 2015;125(16):2544-52. Su, 2014, MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development, Int J Biochem Cell Biol, 49, 53, 10.1016/j.biocel.2014.01.005 Mahmoud, 2013, Meis1 regulates postnatal cardiomyocyte cell cycle arrest, Nature, 497, 249, 10.1038/nature12054 Islam, 2013, Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation, Biol Open, 2, 1125, 10.1242/bio.20132279 Nguyen, 2020, A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes, Nature, 582, 271, 10.1038/s41586-020-2228-6 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, et al. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife 2016;5. Pfeufer, 2010, Genome-wide association study of PR interval, Nat Genet, 42, 153, 10.1038/ng.517 Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, et al. Genome-wide association studies of the PR interval in African Americans. PLoS Genet 2011;7(2):e1001304. Reithmann, 1998, Fast pathway ablation in patients with common atrioventricular nodal reentrant tachycardia and prolonged PR interval during sinus rhythm, Eur Heart J, 19, 929, 10.1053/euhj.1997.0837 Wang, 2006, Heart failure and protein quality control, Circ Res, 99, 1315, 10.1161/01.RES.0000252342.61447.a2 Mearini, 2008, The ubiquitin-proteasome system in cardiac dysfunction, Biochim Biophys Acta, 1782, 749, 10.1016/j.bbadis.2008.06.009 Barac, 2017, The ubiquitin-proteasome system: A potential therapeutic target for heart failure, J Heart Lung Transplant, 36, 708, 10.1016/j.healun.2017.02.012 Nakayama, 2006, Ubiquitin ligases: cell-cycle control and cancer, Nat Rev Cancer, 6, 369, 10.1038/nrc1881 Amador, 2007, APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase, Mol Cell, 27, 462, 10.1016/j.molcel.2007.06.013 Liu, 2018, PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21, Cell Rep, 23, 1461, 10.1016/j.celrep.2018.03.140 Yu, 2015, Analysis of Gene Expression During the Development of Congestive Heart Failure After Myocardial Infarction in Rat Models, Int Heart J, 56, 444, 10.1536/ihj.14-422 Lindsey, 2018, Guidelines for experimental models of myocardial ischemia and infarction, Am J Physiol Heart Circ Physiol, 314, H812, 10.1152/ajpheart.00335.2017 Wang, 2016, Activation of Wnt/beta-catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression, Free Radic Biol Med, 96, 34, 10.1016/j.freeradbiomed.2016.04.003 Kelly A, Salerno S, Connolly A, Bishop M, Charpentier F, Stolen T, et al. Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome. Cardiovasc Res 2018;114(5):724-36. Garcia-Cuellar, 2015, Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia, Haematologica, 100, 905, 10.3324/haematol.2015.124032 Morreale, 2016, Types of Ubiquitin Ligases, Cell, 165, 248, 10.1016/j.cell.2016.03.003 Solomon, 2005, Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both, N Engl J Med, 352, 2581, 10.1056/NEJMoa043938 Gholamzadeh, 2015, Erythropoietin Reduces Post-PCI Arrhythmias in Patients With ST-elevation Myocardial Infarction, J Cardiovasc Pharmacol, 65, 555, 10.1097/FJC.0000000000000223 Aksoz, 2018, Emerging Roles of Meis1 in Cardiac Regeneration, Stem Cells and Cancer, Curr Drug Targets, 19, 181, 10.2174/1389450118666170724165514 Remme, 2010, Sodium channel (dys)function and cardiac arrhythmias, Cardiovasc Ther, 28, 287, 10.1111/j.1755-5922.2010.00210.x Waddell-Smith, 2020, Pre-Test Probability and Genes and Variants of Uncertain Significance in Familial Long QT Syndrome, Heart Lung Circ, 29, 512, 10.1016/j.hlc.2019.12.011 Hu, 2007, Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction, Heart Rhythm, 4, 1072, 10.1016/j.hrthm.2007.03.040 Lawrence, 1978, Transmission of hormonal stimulation by cell-to-cell communication, Nature, 272, 501, 10.1038/272501a0 Zhang, 2016, Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy, IUBMB Life, 68, 13, 10.1002/iub.1456 Xie, 2018, CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy, Theranostics, 8, 5995, 10.7150/thno.27706