Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
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Minichiello, 1996, TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons, Genes Dev, 10, 2849, 10.1101/gad.10.22.2849
Schwartz, 1997, Abnormal cerebellar development and foliation in BDNF−/− mice reveals a role for neurotrophins in CNS patterning, Neuron, 19, 269, 10.1016/S0896-6273(00)80938-1
Bibel, 2000, Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system, Genes Dev, 14, 2919, 10.1101/gad.841400
Martin, 1988, Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation, J Cell Biol, 106, 829, 10.1083/jcb.106.3.829
Aloyz, 1998, p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors, J Cell Biol, 143, 1691, 10.1083/jcb.143.6.1691
Le-Niculescu, 1999, Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to fas ligand induction and cell death, Mol Cell Biol, 19, 751, 10.1128/MCB.19.1.751
Raoul, 1999, Programmed cell death of embryonic motoneurons triggered through the Fas death receptor, J Cell Biol, 147, 1049, 10.1083/jcb.147.5.1049
Gross, 1999, BCL-2 family members and the mitochondria in apoptosis, Genes Dev, 13, 1899, 10.1101/gad.13.15.1899
Deveraux, 1999, IAP family proteins — suppressors of apoptosis, Genes Dev, 13, 239, 10.1101/gad.13.3.239
Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8
Verhagen, 2000, Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins, Cell, 102, 43, 10.1016/S0092-8674(00)00009-X
Deshmukh, 1998, Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c, Neuron, 21, 695, 10.1016/S0896-6273(00)80587-5
Vanhaesebroeck, 2000, The PI3K–PDK1 connection: more than just a road to PKB, Biochem J, 346, 561, 10.1042/0264-6021:3460561
Yao, 1995, Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor, Science, 267, 2003, 10.1126/science.7701324
Dudek, 1997, Regulation of neuronal survival by the serine-threonine protein kinase Akt, Science, 275, 661, 10.1126/science.275.5300.661
Miller, 1997, Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells, J Biol Chem, 272, 9847, 10.1074/jbc.272.15.9847
Philpott, 1997, Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons, J Cell Biol, 139, 809, 10.1083/jcb.139.3.809
Crowder, 1998, Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons, J Neurosci, 18, 2933, 10.1523/JNEUROSCI.18-08-02933.1998
Eves, 1998, Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line, Mol Cell Biol, 18, 2143, 10.1128/MCB.18.4.2143
Hetman, 1999, Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase, J Biol Chem, 274, 22569, 10.1074/jbc.274.32.22569
Vaillant, 1999, Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival, J Cell Biol, 146, 955, 10.1083/jcb.146.5.955
Kuruvilla, 2000, Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons, Neuron, 27, 499, 10.1016/S0896-6273(00)00061-1
Brunet, 2001, The protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1/FOXO3a, Mol Cell Biol, 21, 952, 10.1128/MCB.21.3.952-965.2001
Liu, 2000, Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival, Curr Biol, 10, 1233, 10.1016/S0960-9822(00)00733-8
Cohen, 1999, The development and therapeutic potential of protein kinase inhibitors, Curr Opin Chem Biol, 3, 459, 10.1016/S1367-5931(99)80067-2
Alessi, 1996, Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase, FEBS Lett, 399, 333, 10.1016/S0014-5793(96)01370-1
Gingras, 1998, 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway, Genes Dev, 12, 502, 10.1101/gad.12.4.502
Fulton, 1999, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt, Nature, 399, 597, 10.1038/21218
Kang, 1999, Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit, J Biol Chem, 274, 13085, 10.1074/jbc.274.19.13085
Altiok, 1999, Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-kinase/AKT in breast cancer cells, J Biol Chem, 274, 32274, 10.1074/jbc.274.45.32274
Zimmermann, 1999, Phosphorylation and regulation of Raf by Akt (protein kinase B), Science, 286, 1741, 10.1126/science.286.5445.1741
Ozes, 1999, NF-κB activation by tumour necrosis factor requires the Akt serine- threonine kinase, Nature, 401, 82, 10.1038/43466
Romashkova, 1999, NF-κB is a target of AKT in anti-apoptotic PDGF signalling, Nature, 401, 86, 10.1038/43474
Cross, 1995, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378, 785, 10.1038/378785a0
Lin, 1997, daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science, 278, 1319, 10.1126/science.278.5341.1319
Ogg, 1997, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans, Nature, 389, 994, 10.1038/40194
Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4
Kops, 1999, Direct control of the Forkhead transcription factor AFX by protein kinase B, Nature, 398, 630, 10.1038/19328
Biggs, 1999, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1, Proc Natl Acad Sci USA, 96, 7421, 10.1073/pnas.96.13.7421
Dijkers, 2000, Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1), Mol Cell Biol, 20, 9138, 10.1128/MCB.20.24.9138-9148.2000
Nakamura, 2000, Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN, Mol Cell Biol, 20, 8969, 10.1128/MCB.20.23.8969-8982.2000
Dijkers, 2000, Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1, Curr Biol, 10, 1201, 10.1016/S0960-9822(00)00728-4
O'Reilly, 2000, The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells, Am J Pathol, 157, 449, 10.1016/S0002-9440(10)64557-9
Medema, 2000, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature, 404, 782, 10.1038/35008115
Boussiotis, 2000, p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes, Nat Med, 6, 290, 10.1038/73144
Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 2001, in press.This paper demonstrates that p53 acts downstream of Akt in primary hippocampal neurons. In this system, apoptosis can be induced by hypoxia and nitric oxide, and Akt inhibits such apoptosis by downregulating the transcriptional activity of p53. Akt promotes survival in part by preventing the transcription of p53 target death genes, as expression of Akt blocks the induction of the pro-apoptotic Bcl-2 family member BAX.
Miyashita, 1995, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene, Cell, 80, 293, 10.1016/0092-8674(95)90412-3
Deckwerth, 1996, BAX is required for neuronal death after trophic factor deprivation and during development, Neuron, 17, 401, 10.1016/S0896-6273(00)80173-7
Zhou, 2000, Akt regulates cell survival and apoptosis at a postmitochondrial level, J Cell Biol, 151, 483, 10.1083/jcb.151.3.483
Oda, 2000, Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis, Science, 288, 1053, 10.1126/science.288.5468.1053
Oda, 2000, p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53, Cell, 102, 849, 10.1016/S0092-8674(00)00073-8
Du, 1998, CREB is a regulatory target for the protein kinase Akt/PKB, J Biol Chem, 273, 32377, 10.1074/jbc.273.49.32377
Bonni, 1999, Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms, Science, 286, 1358, 10.1126/science.286.5443.1358
Riccio, 1999, Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons, Science, 286, 2358, 10.1126/science.286.5448.2358
Maggirwar, 1998, Nerve growth factor-dependent activation of NF-κB contributes to survival of sympathetic neurons, J Neurosci, 18, 10356, 10.1523/JNEUROSCI.18-24-10356.1998
Chen, 2000, The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-xL, Mol Cell Biol, 20, 2687, 10.1128/MCB.20.8.2687-2695.2000
Zong, 1999, The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis, Genes Dev, 13, 382, 10.1101/gad.13.4.382
Chu, 1997, Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control, Proc Natl Acad Sci USA, 94, 10057, 10.1073/pnas.94.19.10057
Tao, 1998, Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism, Neuron, 20, 709, 10.1016/S0896-6273(00)81010-7
Datta, 1997, Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery, Cell, 91, 231, 10.1016/S0092-8674(00)80405-5
del Peso, 1997, Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt, Science, 278, 687, 10.1126/science.278.5338.687
Datta, 2000, 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation, Mol Cell, 6, 41, 10.1016/S1097-2765(00)00006-X
Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 282, 1318, 10.1126/science.282.5392.1318
Fujita, 1999, Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9, Biochem Biophys Res Commun, 264, 550, 10.1006/bbrc.1999.1387
Crowder, 2000, Glycogen synthase kinase-3β activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal, J Biol Chem, 275, 34266, 10.1074/jbc.M006160200
Hetman, 2000, Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal, J Neurosci, 20, 2567, 10.1523/JNEUROSCI.20-07-02567.2000
Rathmell, 2000, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability, Mol Cell, 6, 683, 10.1016/S1097-2765(00)00066-6
Vander Heiden, 2000, Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival, Proc Natl Acad Sci USA, 97, 4666, 10.1073/pnas.090082297
Kennedy, 1999, Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria, Mol Cell Biol, 19, 5800, 10.1128/MCB.19.8.5800
Kohn, 1996, Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation, J Biol Chem, 271, 31372, 10.1074/jbc.271.49.31372
Liao, 1998, Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene, J Biol Chem, 273, 27320, 10.1074/jbc.273.42.27320
Dickens, 1998, Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin, J Biol Chem, 273, 20144, 10.1074/jbc.273.32.20144
Barthel, 1999, Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1, J Biol Chem, 274, 20281, 10.1074/jbc.274.29.20281
Harada, 1999, Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A, Mol Cell, 3, 413, 10.1016/S1097-2765(00)80469-4
Shimamura, 2000, Rsk1 mediates a MEK-MAP kinase cell survival signal, Curr Biol, 10, 127, 10.1016/S0960-9822(00)00310-9
Meyer-Franke, 1995, Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture, Neuron, 15, 805, 10.1016/0896-6273(95)90172-8
Blair, 1999, Akt-dependent potentiation of L channels by insulin-like growth factor- 1 is required for neuronal survival, J Neurosci, 19, 1940, 10.1523/JNEUROSCI.19-06-01940.1999
Ghosh, 1995, Calcium signaling in neurons: molecular mechanisms and cellular consequences, Science, 268, 239, 10.1126/science.7716515
Pap, 1998, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway, J Biol Chem, 273, 19929, 10.1074/jbc.273.32.19929
Putcha, 2001, Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis, Neuron, 29, 615, 10.1016/S0896-6273(01)00238-0