Transcranial DC stimulation modifies functional connectivity of large‐scale brain networks in abstinent methamphetamine users

Brain and Behavior - Tập 8 Số 3 - 2018
Alireza Shahbabaie1,2,3,4, Mitra Ebrahimpoor5,4, Ali Hariri6,7, Michael A. Nitsche1, Javad Hatami8,2, Emad Fatemizadeh6, Mohammad Ali Oghabian4, Hamed Ekhtiari2,3,4
1Department of Psychology and Neurosciences, Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany
2Institute for Cognitive Science Studies, Tehran, Iran
3Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
4Neuroimaging and Analysis Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran
5Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
6Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
7Department of NanoEngineering and Materials Science and Engineering Program University of California San Diego La Jolla CA USA
8Department of Psychology and Educational Sciences, University of Tehran, Tehran, Iran

Tóm tắt

AbstractBackground

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool suited to alter cortical excitability and activity via the application of weak direct electrical currents. An increasing number of studies in the addiction literature suggests thattDCSmodulates subjective self‐reported craving through stimulation of dorsolateral prefrontal cortex (DLPFC). The major goal of this study was to explore effects of bilateralDLPFCstimulation on resting state networks (RSNs) in association with drug craving modulation. We targeted three large‐scaleRSNs; the default mode network (DMN), the executive control network (ECN), and the salience network (SN).

Methods

Fifteen males were recruited after signing written informed consent. We conducted a double‐blinded sham‐controlled crossover study. Twenty‐minute “real” and “sham”tDCS(2 mA) were applied over theDLPFCon two separate days in random order. Each subject received both stimulation conditions with a 1‐week washout period. The anode and cathode electrodes were located over the right and leftDLPFC, respectively. Resting statefMRIwas acquired before and after real and sham stimulation. Subjective craving was assessed before and after eachfMRIscan. TheRSNs were identified using seed‐based analysis and were compared using a generalized linear model.

Results

Subjective craving decreased significantly after realtDCScompared to sham stimulation (p = .03). Moreover, the analysis shows significant modulation ofDMN,ECN, andSNafter realtDCScompared to sham stimulation. Additionally, alteration of subjective craving score was correlated with modified activation of the three networks.

Discussion

Given the observed alteration of the targeted functional brain networks in methamphetamine users, new potentials are highlighted fortDCSas a network intervention strategy and rsfMRIas a suitable monitoring method for these interventions.

Từ khóa


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Brain and Behavior

Tập 8 Số 3

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