Tramadol overdose: review of the literature

Lavoisier - Tập 20 - Trang 436-441 - 2011
R. Afshari1, R. Afshar1, B. Mégarbane2
1Medical Toxicology Research Centre, Medical Toxicology Centre, Mashhad University of Medical Sciences, Mashhad, Iran
2Réanimation médicale et toxicologique, hôpital Lariboisière, université Paris-Diderot, Inserm, Paris, France

Tóm tắt

La France, à l’instar de plusieurs autres pays européens, a décidé de retirer du marché en 2011 toutes les spécialités à base de dextropropoxyphène. De ce fait, une augmentation significative des prescriptions d’antalgiques à base de tramadol pourrait être observée, avec comme conséquence une augmentation des cas de surdosage et d’intoxication. Le tramadol est un opioïde de synthèse à l’origine de nombreux risques y compris vitaux pouvant conduire un patient intoxiqué en réanimation : troubles de la conscience, convulsions, syndrome sérotoninergique et plus rarement hypotension et état de choc. De telles observations ont largement été documentées en Iran, où ce médicament est à l’origine d’un détournement d’usage chez les consommateurs de drogues dépendants aux opioïdes. Une vigilance particulière doit donc être instaurée en France pour éviter que le tramadol ne conduise à son tour à un accroissement significatif de la morbimortalité des intoxications aiguës, comme déjà observé en Iran.

Tài liệu tham khảo

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