Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases
Tài liệu tham khảo
Mairan, 1729, Observation botanique, Histoire de l'Academie Royale des Sciences, 35
Mohawk, 2012, Central and peripheral circadian clocks in mammals, Annu. Rev. Neurosci., 35, 445, 10.1146/annurev-neuro-060909-153128
Hatori, 2010, The emerging roles of melanopsin in behavioral adaptation to light, Trends Mol. Med., 16, 435, 10.1016/j.molmed.2010.07.005
Hardin, 2013, Circadian timekeeping and output mechanisms in animals, Curr. Opin. Neurobiol., 23, 724, 10.1016/j.conb.2013.02.018
Zhang, 2014, A circadian gene expression atlas in mammals: implications for biology and medicine, Proc. Natl. Acad. Sci. U. S. A., 111, 16219, 10.1073/pnas.1408886111
Mure, 2018, Diurnal transcriptome atlas of a primate across major neural and peripheral tissues, Science, 359, 10.1126/science.aao0318
Robles, 2014, In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism, PLoS Genet., 10, 10.1371/journal.pgen.1004047
Robles, 2016, Phosphorylation is a central mechanism for circadian control of metabolism and physiology, Cell Metab., 25, 118, 10.1016/j.cmet.2016.10.004
Kondratov, 2006, Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock, Genes Dev., 20, 1868, 10.1101/gad.1432206
Rakshit, 2013, Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila, Aging Cell, 12, 752, 10.1111/acel.12100
LeGates, 2014, Light as a central modulator of circadian rhythms, sleep and affect, Nat. Rev. Neurosci., 15, 443, 10.1038/nrn3743
Lunn, 2017, Health consequences of electric lighting practices in the modern world: a report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption, Sci. Total Environ., 607–608, 1073, 10.1016/j.scitotenv.2017.07.056
Kohsaka, 2007, High-fat diet disrupts behavioral and molecular circadian rhythms in mice, Cell Metab., 6, 414, 10.1016/j.cmet.2007.09.006
Damiola, 2000, Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus, Genes Dev., 14, 2950, 10.1101/gad.183500
Stokkan, 2001, Entrainment of the circadian clock in the liver by feeding, Science, 291, 490, 10.1126/science.291.5503.490
Welsh, 1988, Effect of running wheel availability on circadian patterns of sleep and wakefulness in mice, Physiol. Behav., 43, 771, 10.1016/0031-9384(88)90375-7
Ehlen, 2017, Bma function in skeletal muscle regulates sleep, Elife, 6, 10.7554/eLife.26557
Parekh, 2015, Sleep disorders and inflammatory disease activity: chicken or the egg?, Am. J. Gastroenterol., 110, 484, 10.1038/ajg.2014.247
Kettner, 2016, Circadian homeostasis of liver metabolism suppresses hepatocarcinogenesis, Cancer Cell, 30, 909, 10.1016/j.ccell.2016.10.007
Knutsson, 2010, Gastrointestinal disorders among shift workers, Scand. J. Work Environ. Health, 36, 85, 10.5271/sjweh.2897
Puttonen, 2010, Shift work and cardiovascular disease – pathways from circadian stress to morbidity, Scand. J. Work Environ. Health, 36, 96, 10.5271/sjweh.2894
Pan, 2011, Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women, PLoS Med., 8, 10.1371/journal.pmed.1001141
Haus, 2013, Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation, Sleep Med. Rev., 17, 273, 10.1016/j.smrv.2012.08.003
Qian, 2016, Circadian System and Glucose Metabolism: implications for Physiology and Disease, Trends Endocrinol. Metab., 27, 282, 10.1016/j.tem.2016.03.005
Miller, 2004, Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy, Curr. Biol., 14, 1367, 10.1016/j.cub.2004.07.055
de la Iglesia, 2006, Minireview: timely ovulation: circadian regulation of the female hypothalamo-pituitary-gonadal axis, Endocrinology, 147, 1148, 10.1210/en.2005-1311
Gamble, 2013, Shift work and circadian dysregulation of reproduction, Front. Endocrinol. (Lausanne), 4, 92, 10.3389/fendo.2013.00092
Azzi, 2014, Circadian behavior is light-reprogrammed by plastic DNA methylation, Nat. Neurosci., 17, 377, 10.1038/nn.3651
Anderson, 2017, Self-regulation and household routines at age three and obesity at age eleven: longitudinal analysis of the UK Millennium Cohort Study, Int. J. Obes. (Lond.), 41, 1459, 10.1038/ijo.2017.94
Kronfeld-Schor, 2012, Circadian rhythms and depression: human psychopathology and animal models, Neuropharmacology, 62, 101, 10.1016/j.neuropharm.2011.08.020
Wulff, 2010, Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease, Nat. Rev. Neurosci., 11, 589, 10.1038/nrn2868
Scheiermann, 2013, Circadian control of the immune system, Nat. Rev. Immunol., 13, 190, 10.1038/nri3386
Gibbs, 2014, An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action, Nat. Med., 20, 919, 10.1038/nm.3599
Nakazato, 2017, Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction, J. Neurosci., 37, 10052, 10.1523/JNEUROSCI.3639-16.2017
Zhang, 2018, A circadian clock in the blood-brain barrier regulates xenobiotic efflux, Cell, 173, 10.1016/j.cell.2018.02.017
Mendez-Ferrer, 2008, Haematopoietic stem cell release is regulated by circadian oscillations, Nature, 452, 442, 10.1038/nature06685
Druzd, 2017, Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses, Immunity, 46, 120, 10.1016/j.immuni.2016.12.011
Man, 2016, Immunity around the clock, Science, 354, 999, 10.1126/science.aah4966
Musiek, 2013, Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, J. Clin. Invest., 123, 5389, 10.1172/JCI70317
Musiek, 2016, Mechanisms linking circadian clocks, sleep, and neurodegeneration, Science, 354, 1004, 10.1126/science.aah4968
Castanon-Cervantes, 2010, Dysregulation of inflammatory responses by chronic circadian disruption, J. Immunol., 185, 5796, 10.4049/jimmunol.1001026
Feillet, 2015, Coupling between the circadian clock and cell cycle oscillators: implication for healthy cells and malignant growth, Front. Neurol., 6, 96, 10.3389/fneur.2015.00096
Gaucher, 2018, Molecular cogs: interplay between circadian clock and cell cycle, Trends Cell Biol., 368, 10.1016/j.tcb.2018.01.006
Manoogian, 2016, Circadian rhythms, time-restricted feeding, and healthy aging, Ageing Res. Rev., 39, 59, 10.1016/j.arr.2016.12.006
Dement, 1999
Liu, 2016, MT1 and MT2 melatonin receptors: a therapeutic perspective, Annu. Rev. Pharmacol. Toxicol., 56, 361, 10.1146/annurev-pharmtox-010814-124742
Morin, 2012, Chronic insomnia, Lancet, 379, 1129, 10.1016/S0140-6736(11)60750-2
Panda, 2002, Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting, Science, 298, 2213, 10.1126/science.1076848
Ruby, 2002, Role of melanopsin in circadian responses to light, Science, 298, 2211, 10.1126/science.1076701
Thapan, 2001, An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans, J. Physiol., 535, 261, 10.1111/j.1469-7793.2001.t01-1-00261.x
Brainard, 2001, Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor, J. Neurosci., 21, 6405, 10.1523/JNEUROSCI.21-16-06405.2001
Hatori, 2017, Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies, NPJ Aging Mech. Dis., 3, 9, 10.1038/s41514-017-0010-2
Lucas, 2014, Measuring and using light in the melanopsin age, Trends Neurosci., 37, 1, 10.1016/j.tins.2013.10.004
Loria, 2017
LeGates, 2012, Aberrant light directly impairs mood and learning through melanopsin-expressing neurons, Nature, 491, 594, 10.1038/nature11673
Chen, 2011, Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs, Nature, 476, 92, 10.1038/nature10206
Jones, 2013, Small-molecule antagonists of melanopsin-mediated phototransduction, Nat. Chem. Biol., 9, 630, 10.1038/nchembio.1333
Vollmers, 2009, Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression, Proc. Natl. Acad. Sci. U. S. A., 106, 21453, 10.1073/pnas.0909591106
Chaix, 2014, Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges, Cell Metab., 20, 991, 10.1016/j.cmet.2014.11.001
Wang, 2018, Time-restricted feeding improves circadian dysfunction as well as motor symptoms in the Q175 mouse model of Huntington’s disease, eNeuro, 5, 10.1523/ENEURO.0431-17.2017
Cisse, 2018, Time-restricted feeding alters the innate immune response to bacterial endotoxin, J. Immunol., 200, 681, 10.4049/jimmunol.1701136
Gill, 2015, A Smartphone App reveals erratic diurnal eating patterns in humans that can be modulated for health benefits, Cell Metab., 22, 789, 10.1016/j.cmet.2015.09.005
Moro, 2016, Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males, J. Transl. Med., 14, 290, 10.1186/s12967-016-1044-0
Ronn, 2009, A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals, Diabetologia, 52, 830, 10.1007/s00125-009-1297-8
Prokopenko, 2009, Variants in MTNR1B influence fasting glucose levels, Nat. Genet., 41, 77, 10.1038/ng.290
Bouatia-Naji, 2009, A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk, Nat. Genet., 41, 89, 10.1038/ng.277
Lyssenko, 2009, Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion, Nat. Genet., 41, 82, 10.1038/ng.288
Lopez-Minguez, 2017, Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: a randomized, cross-over study, Clin. Nutr., 37, 1133, 10.1016/j.clnu.2017.04.003
Hrushesky, 1985, Circadian timing of cancer chemotherapy, Science, 228, 73, 10.1126/science.3883493
Levi, 1997, Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy, Lancet, 350, 681, 10.1016/S0140-6736(97)03358-8
Kobayashi, 2002, Circadian chemotherapy for gynecological and genitourinary cancers, Chronobiol. Int., 19, 237, 10.1081/CBI-120002600
Chan, 2017, Does the time of radiotherapy affect treatment outcomes? A review of the literature, Clin. Oncol. (R. Coll. Radiol.), 29, 231, 10.1016/j.clon.2016.12.005
Anafi, 2017, CYCLOPS reveals human transcriptional rhythms in health and disease, Proc. Natl. Acad. Sci. U. S. A., 114, 5312, 10.1073/pnas.1619320114
Dallmann, 2016, Dosing-time makes the poison: circadian regulation and pharmacotherapy, Trends Mol. Med., 22, 430, 10.1016/j.molmed.2016.03.004
Ballesta, 2017, Systems chronotherapeutics, Pharmacol. Rev., 69, 161, 10.1124/pr.116.013441
Buttgereit, 2008, Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial, Lancet, 371, 205, 10.1016/S0140-6736(08)60132-4
Ferrannini, 2010, Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial, Diabetes Care, 33, 2217, 10.2337/dc10-0612
Hermida, 2011, Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications, Am. J. Hypertens., 24, 383, 10.1038/ajh.2010.217
Marciano, 2014, The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARgamma, RORs, and Rev-erbs, Cell Metab., 19, 193, 10.1016/j.cmet.2013.12.009
Sato, 2004, A functional genomics strategy reveals Rora as a component of the mammalian circadian clock, Neuron, 43, 527, 10.1016/j.neuron.2004.07.018
Jones, 2013, Genetic basis of human circadian rhythm disorders, Exp. Neurol., 243, 28, 10.1016/j.expneurol.2012.07.012
Takahashi, 2008, The genetics of mammalian circadian order and disorder: implications for physiology and disease, Nat. Rev. Genet., 9, 764, 10.1038/nrg2430
Marcheva, 2010, Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes, Nature, 466, 627, 10.1038/nature09253
Vieira, 2014, Clock genes, pancreatic function, and diabetes, Trends Mol. Med., 20, 685, 10.1016/j.molmed.2014.10.007
Turek, 2005, Obesity and metabolic syndrome in circadian Clock mutant mice, Science, 308, 1043, 10.1126/science.1108750
Cho, 2012, Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta, Nature, 485, 123, 10.1038/nature11048
Bugge, 2012, Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function, Genes Dev., 26, 657, 10.1101/gad.186858.112
Lamia, 2011, Cryptochromes mediate rhythmic repression of the glucocorticoid receptor, Nature, 480, 552, 10.1038/nature10700
Gibbs, 2012, The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines, Proc. Natl. Acad. Sci. U. S. A., 109, 582, 10.1073/pnas.1106750109
Summa, 2013, Disruption of the circadian clock in mice increases intestinal permeability and promotes alcohol-induced hepatic pathology and inflammation, PLoS One, 8, 10.1371/journal.pone.0067102
Narasimamurthy, 2012, Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines, Proc. Natl. Acad. Sci. U. S. A., 109, 12662, 10.1073/pnas.1209965109
Hand, 2016, The circadian clock regulates inflammatory arthritis, FASEB J., 30, 3759, 10.1096/fj.201600353R
Cao, 2017, Circadian clock cryptochrome proteins regulate autoimmunity, Proc. Natl. Acad. Sci. U. S. A., 114, 12548, 10.1073/pnas.1619119114
Lamont, 2007, The role of circadian clock genes in mental disorders, Dialogues Clin. Neurosci., 9, 333, 10.31887/DCNS.2007.9.3/elamont
Fu, 2002, The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo, Cell, 111, 41, 10.1016/S0092-8674(02)00961-3
Lee, 2010, Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice, PLoS One, 5
Huber, 2016, CRY2 and FBXL3 cooperatively degrade c-MYC, Mol. Cell, 64, 774, 10.1016/j.molcel.2016.10.012
Papagiannakopoulos, 2016, Circadian rhythm disruption promotes lung tumorigenesis, Cell Metab., 24, 324, 10.1016/j.cmet.2016.07.001
Ueda, 2002, High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma, Cancer Res., 62, 901
Dubrovsky, 2010, Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice, Aging (Albany NY), 2, 936, 10.18632/aging.100241
Yuan, 2018, Night shift work increases the risks of multiple primary cancers in women: a systematic review and meta-analysis of 61 articles, Cancer Epidemiol. Biomarkers Prev., 27, 25, 10.1158/1055-9965.EPI-17-0221
McHill, 2014, Impact of circadian misalignment on energy metabolism during simulated nightshift work, Proc. Natl. Acad. Sci., 111, 17302, 10.1073/pnas.1412021111
Chomez, 2000, Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor, Development, 127, 1489, 10.1242/dev.127.7.1489
Panda, 2016, Circadian physiology of metabolism, Science, 354, 1008, 10.1126/science.aah4967
He, 2016, The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome, Cell Metab., 23, 610, 10.1016/j.cmet.2016.03.007
Murakami, 2000, Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice, Cancer Res., 60, 5059
Solt, 2011, Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand, Nature, 472, 491, 10.1038/nature10075
Wang, 2010, Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and RORgamma, ACS Chem. Biol., 5, 1029, 10.1021/cb100223d
Kumar, 2011, Identification of SR3335 (ML-176): a synthetic RORalpha selective inverse agonist, ACS Chem. Biol., 6, 218, 10.1021/cb1002762
Kumar, 2012, Identification of SR2211: a potent synthetic RORgamma-selective modulator, ACS Chem. Biol., 7, 672, 10.1021/cb200496y
Wang, 2016, ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer, Nat. Med., 22, 488, 10.1038/nm.4070
Zhang, 2014, Discovery of 2-oxo-1,2-dihydrobenzocdindole-6-sulfonamide derivatives as new RORgamma inhibitors using virtual screening, synthesis and biological evaluation, Eur. J. Med. Chem., 78, 431, 10.1016/j.ejmech.2014.03.065
Xiao, 2014, Small-molecule RORgammat antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, Immunity, 40, 477, 10.1016/j.immuni.2014.04.004
Solt, 2012, Identification of a selective RORgamma ligand that suppresses T(H)17 cells and stimulates T regulatory cells, ACS Chem. Biol., 7, 1515, 10.1021/cb3002649
Hu, 2016, Synthetic RORgamma agonists regulate multiple pathways to enhance antitumor immunity, Oncoimmunology, 5, 10.1080/2162402X.2016.1254854
Xu, 2011, Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein, J. Biol. Chem., 286, 22707, 10.1074/jbc.C111.250407
Huh, 2011, Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity, Nature, 472, 486, 10.1038/nature09978
Zhang, 2012, Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor gamma (RORgamma) by a class of aryl amide compounds, Mol. Pharmacol., 82, 583, 10.1124/mol.112.078667
Xue, 2016, Pharmacologic modulation of RORgammat translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis, Sci Rep., 6, 10.1038/srep37977
Patouret, 2018, Identification of an aminothiazole series of RORbeta modulators, Bioorg. Med. Chem. Lett., 28, 1178, 10.1016/j.bmcl.2018.03.001
Trump, 2013, Optimized chemical probes for REV-ERBalpha, J. Med. Chem., 56, 4729, 10.1021/jm400458q
Kojetin, 2011, Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB, ACS Chem. Biol., 6, 131, 10.1021/cb1002575
Solt, 2012, Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists, Nature, 485, 62, 10.1038/nature11030
Grant, 2010, GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbalpha, ACS Chem. Biol., 5, 925, 10.1021/cb100141y