Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies

Allinquant, 1994, Amyloid precursor protein in cortical neurons: coexistence of two pools differentially distributed in axons and dendrites and association with cytoskeleton, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 14, 6842, 10.1523/JNEUROSCI.14-11-06842.1994 Allinson, 2003, ADAMs family members as amyloid precursor protein alpha-secretases, Journal of Neuroscience Research, 74, 342, 10.1002/jnr.10737 Alpar, 2006, The expression of wild-type human amyloid precursor protein affects the dendritic phenotype of neocortical pyramidal neurons in transgenic mice, International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, 24, 133, 10.1016/j.ijdevneu.2005.11.008 Alpar, 2006, Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice, Brain Research, 1099, 189, 10.1016/j.brainres.2006.04.109 Anders, 2001, Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 15, 1837, 10.1096/fj.01-0007fje Andersen, 2005, Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein, Proceedings of the National Academy of Sciences of the United States of America, 102, 13461, 10.1073/pnas.0503689102 Ando, 2001, Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid, The Journal of Biological Chemistry, 276, 40353, 10.1074/jbc.M104059200 Ando, 1999, Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 19, 4421, 10.1523/JNEUROSCI.19-11-04421.1999 Annaert, 2001, Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins, Neuron, 32, 579, 10.1016/S0896-6273(01)00512-8 Araki, 2007, The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport, The EMBO Journal, 26, 1475, 10.1038/sj.emboj.7601609 Arduise, 2008, Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor, Journal of Immunology, 181, 7002, 10.4049/jimmunol.181.10.7002 Arighi, 2004, Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor, The Journal of Cell Biology, 165, 123, 10.1083/jcb.200312055 Ashley, 2005, Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 25, 5943, 10.1523/JNEUROSCI.1144-05.2005 Baas, 1988, Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite, Proceedings of the National Academy of Sciences of the United States of America, 85, 8335, 10.1073/pnas.85.21.8335 Bagal, 2005, Long-term potentiation of exogenous glutamate responses at single dendritic spines, Proceedings of the National Academy of Sciences of the United States of America, 102, 14434, 10.1073/pnas.0501956102 Baki, 2008, Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 28, 483, 10.1523/JNEUROSCI.4067-07.2008 Baki, 2004, PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations, The EMBO Journal, 23, 2586, 10.1038/sj.emboj.7600251 Bardo, 2006, The role of the endoplasmic reticulum Ca2+ store in the plasticity of central neurons, Trends in Pharmacological Sciences, 27, 78, 10.1016/j.tips.2005.12.008 Barkus, 2008, Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides, Molecular Biology of the Cell, 19, 274, 10.1091/mbc.e07-03-0261 Barr, 2001, Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus, The Journal of Cell Biology, 155, 885, 10.1083/jcb.200108102 Barrow, 2000, Functional phenotype in transgenic mice expressing mutant human presenilin-1, Neurobiology of Disease, 7, 119, 10.1006/nbdi.1999.0276 Begley, 1999, Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice, Journal of Neurochemistry, 72, 1030, 10.1046/j.1471-4159.1999.0721030.x Benjannet, 2004, The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing, Biochemical and Biophysical Research Communications, 325, 235, 10.1016/j.bbrc.2004.10.019 Benjannet, 2001, Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production, The Journal of Biological Chemistry, 276, 10879, 10.1074/jbc.M009899200 Bennett, 2000, A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase, The Journal of Biological Chemistry, 275, 37712, 10.1074/jbc.M005339200 Berezovska, 2003, Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1–gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23, 4560, 10.1523/JNEUROSCI.23-11-04560.2003 Bergman, 2004, Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin, The Journal of Biological Chemistry, 279, 16744, 10.1074/jbc.M313999200 Biederer, 2002, Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, 7340, 10.1523/JNEUROSCI.22-17-07340.2002 Bittner, 2009, Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29, 10405, 10.1523/JNEUROSCI.2288-09.2009 Blum, 1996, Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking, The Journal of Biological Chemistry, 271, 17183, 10.1074/jbc.271.29.17183 Bodendorf, 2001, A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein, The Journal of Biological Chemistry, 276, 12019, 10.1074/jbc.M008861200 Boman, 2001, GGA proteins: new players in the sorting game, Journal of Cell Science, 114, 3413, 10.1242/jcs.114.19.3413 Bonifacino, 2004, The GGA proteins: adaptors on the move. Nature reviews, Molecular Cell Biology, 5, 23 Bonifacino, 2008, Retromer, Current Opinion in Cell Biology, 20, 427, 10.1016/j.ceb.2008.03.009 Bonifacino, 2006, Retrograde transport from endosomes to the trans-Golgi network. Nature reviews, Molecular Cell Biology, 7, 568 Bonifacino, 2003, Signals for sorting of transmembrane proteins to endosomes and lysosomes, Annual Review of Biochemistry, 72, 395, 10.1146/annurev.biochem.72.121801.161800 Borg, 1996, The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein, Molecular and Cellular Biology, 16, 6229, 10.1128/MCB.16.11.6229 Bourne, 2008, Balancing structure and function at hippocampal dendritic spines, Annual Review of Neuroscience, 31, 47, 10.1146/annurev.neuro.31.060407.125646 Bredt, 2003, AMPA receptor trafficking at excitatory synapses, Neuron, 40, 361, 10.1016/S0896-6273(03)00640-8 Bressler, 1996, cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein, Human Molecular Genetics, 5, 1589, 10.1093/hmg/5.10.1589 Brou, 2000, A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE, Molecular Cell, 5, 207, 10.1016/S1097-2765(00)80417-7 Brown, 2000, Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans, Cell, 100, 391, 10.1016/S0092-8674(00)80675-3 Burgos, 2010, Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex, Developmental Cell, 18, 425, 10.1016/j.devcel.2010.01.015 Buxbaum, 1998, Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 18, 9629, 10.1523/JNEUROSCI.18-23-09629.1998 Cai, 2003, Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein, The Journal of Biological Chemistry, 278, 3446, 10.1074/jbc.M209065200 Cai, 1993, Release of excess amyloid beta protein from a mutant amyloid beta protein precursor, Science (New York, NY), 259, 514, 10.1126/science.8424174 Camden, 2005, P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing, The Journal of Biological Chemistry, 280, 18696, 10.1074/jbc.M500219200 Campion, 1995, Mutations of the presenilin I gene in families with early-onset Alzheimer's disease, Human Molecular Genetics, 4, 2373, 10.1093/hmg/4.12.2373 Cao, 2001, A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60, Science (New York, NY), 293, 115, 10.1126/science.1058783 Capell, 2005, Gamma-secretase complex assembly within the early secretory pathway, The Journal of Biological Chemistry, 280, 6471, 10.1074/jbc.M409106200 Capell, 2003, Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain, The Journal of Biological Chemistry, 278, 52519, 10.1074/jbc.C300435200 Capell, 2000, Maturation and pro-peptide cleavage of beta-secretase, The Journal of Biological Chemistry, 275, 30849, 10.1074/jbc.M003202200 Caporaso, 1992, Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein, Proceedings of the National Academy of Sciences of the United States of America, 89, 3055, 10.1073/pnas.89.7.3055 Caporaso, 1994, Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 14, 3122, 10.1523/JNEUROSCI.14-05-03122.1994 Carroll, 1999, Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures, Nature Neuroscience, 2, 454, 10.1038/8123 Chada, 2003, Mitochondrial movement and positioning in axons: the role of growth factor signaling, The Journal of Experimental Biology, 206, 1985, 10.1242/jeb.00263 Chada, 2004, Nerve growth factor signaling regulates motility and docking of axonal mitochondria, Current Biology: CB, 14, 1272, 10.1016/j.cub.2004.07.027 Chaufty, 2012, Intracellular amyloid precursor protein sorting and amyloid-beta secretion are regulated by Src-mediated phosphorylation of Mint2, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32, 9613, 10.1523/JNEUROSCI.0602-12.2012 Chen, 2006, TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity, Nature, 440, 1208, 10.1038/nature04667 Chen, 2003, Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain, The Journal of Biological Chemistry, 278, 19974, 10.1074/jbc.M210049200 Chen, 2001, Nicastrin binds to membrane-tethered Notch, Nature Cell Biology, 3, 751, 10.1038/35087069 Chen, 1990, NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor, The Journal of Biological Chemistry, 265, 3116, 10.1016/S0021-9258(19)39742-X Cirrito, 2008, Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo, Neuron, 58, 42, 10.1016/j.neuron.2008.02.003 Cirrito, 2005, Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo, Neuron, 48, 913, 10.1016/j.neuron.2005.10.028 Cochet, 2013, 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10, ACS Chemical Neuroscience, 4, 130, 10.1021/cn300095t Colciaghi, 2002, [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients, Molecular Medicine, 8, 67, 10.1007/BF03402076 Colombo, 2012, Constitutive alpha- and beta-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines, Neurobiology of Disease, 49C, 137 Cooney, 2002, Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, 2215, 10.1523/JNEUROSCI.22-06-02215.2002 Cousins, 2009, Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery, Journal of Neurochemistry, 111, 1501, 10.1111/j.1471-4159.2009.06424.x Craig, 1994, Neuronal polarity, Annual Review of Neuroscience, 17, 267, 10.1146/annurev.ne.17.030194.001411 Creemers, 2001, Processing of beta-secretase by furin and other members of the proprotein convertase family, The Journal of Biological Chemistry, 276, 4211, 10.1074/jbc.M006947200 Crystal, 2003, Membrane topology of gamma-secretase component PEN-2, The Journal of Biological Chemistry, 278, 20117, 10.1074/jbc.M213107200 da Silva, 2002, Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis. Nature reviews, Neuroscience, 3, 694 Dash, 1993, Inhibitors of endocytosis, endosome fusion, and lysosomal processing inhibit the intracellular proteolysis of the amyloid precursor protein, Neuroscience Letters, 164, 183, 10.1016/0304-3940(93)90887-Q De Strooper, 2003, Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex, Neuron, 38, 9, 10.1016/S0896-6273(03)00205-8 De Strooper, 1999, A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature, 398, 518, 10.1038/19083 Dominguez, 2005, Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice, The Journal of Biological Chemistry, 280, 30797, 10.1074/jbc.M505249200 Donmez, 2010, SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10, Cell, 142, 320, 10.1016/j.cell.2010.06.020 Dornier, 2012, TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals, The Journal of Cell Biology, 199, 481, 10.1083/jcb.201201133 Dreses-Werringloer, 2008, A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk, Cell, 133, 1149, 10.1016/j.cell.2008.05.048 Duilio, 1998, Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein, The Biochemical Journal, 330, 513, 10.1042/bj3300513 Edbauer, 2004, Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1, The Journal of Biological Chemistry, 279, 37311, 10.1074/jbc.M406228200 Edbauer, 2003, Reconstitution of gamma-secretase activity, Nature Cell Biology, 5, 486, 10.1038/ncb960 Ehlers, 2000, Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting, Neuron, 28, 511, 10.1016/S0896-6273(00)00129-X Epis, 2010, Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease, Brain: A Journal of Neurology, 133, 3323, 10.1093/brain/awq217 Esler, 2000, Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1, Nature Cell Biology, 2, 428, 10.1038/35017062 Esler, 2002, Activity-dependent isolation of the presenilin–gamma-secretase complex reveals nicastrin and a gamma substrate, Proceedings of the National Academy of Sciences of the United States of America, 99, 2720, 10.1073/pnas.052436599 Esselens, 2004, Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway, The Journal of Cell Biology, 166, 1041, 10.1083/jcb.200406060 Fahrenholz, 2000, Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure, Annals of the New York Academy of Sciences, 920, 215, 10.1111/j.1749-6632.2000.tb06925.x Ferreira, 1993, Intraneuronal compartments of the amyloid precursor protein, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 13, 3112, 10.1523/JNEUROSCI.13-07-03112.1993 Fiore, 1995, The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein, The Journal of Biological Chemistry, 270, 30853, 10.1074/jbc.270.52.30853 Foletti, 1999, Generation and maintenance of neuronal polarity: mechanisms of transport and targeting, Neuron, 23, 641, 10.1016/S0896-6273(01)80022-2 Fortna, 2004, Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex, The Journal of Biological Chemistry, 279, 3685, 10.1074/jbc.M310505200 Fraering, 2004, Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex, Biochemistry, 43, 323, 10.1021/bi035748j Fraering, 2004, Purification and characterization of the human gamma-secretase complex, Biochemistry, 43, 9774, 10.1021/bi0494976 Francis, 2002, aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation, Developmental Cell, 3, 85, 10.1016/S1534-5807(02)00189-2 Fukumoto, 2002, Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease, Archives of Neurology, 59, 1381, 10.1001/archneur.59.9.1381 Fukumoto, 2004, Beta-secretase activity increases with aging in human, monkey, and mouse brain, The American Journal of Pathology, 164, 719, 10.1016/S0002-9440(10)63159-8 Gandy, 1992, Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine, Annals of the New York Academy of Sciences, 674, 203, 10.1111/j.1749-6632.1992.tb27489.x Gardoni, 2012, The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway, Journal of Cell Science, 125, 1401, 10.1242/jcs.097576 Gatta, 2002, Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus, Neuroreport, 13, 2031, 10.1097/00001756-200211150-00008 Glenner, 1984, Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochemical and Biophysical Research Communications, 120, 885, 10.1016/S0006-291X(84)80190-4 Gralle, 2006, Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein, Journal of Molecular Biology, 357, 493, 10.1016/j.jmb.2005.12.053 Gray, 1959, Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex, Nature, 183, 1592, 10.1038/1831592a0 Gray, 1963, A note on the dendritic spine apparatus, Journal of Anatomy, 97, 389 Grilli, 2000, Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically, Proceedings of the National Academy of Sciences of the United States of America, 97, 12822, 10.1073/pnas.97.23.12822 Groemer, 2011, Amyloid precursor protein is trafficked and secreted via synaptic vesicles, PloS One, 6, e18754, 10.1371/journal.pone.0018754 Gu, 2003, APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes, The Journal of Biological Chemistry, 278, 7374, 10.1074/jbc.M209499200 Guenette, 1996, Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein, Proceedings of the National Academy of Sciences of the United States of America, 93, 10832, 10.1073/pnas.93.20.10832 Guo, 1996, Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide, Neuroreport, 8, 379, 10.1097/00001756-199612200-00074 Guo, 1999, Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation, Journal of Neurochemistry, 72, 1019, 10.1046/j.1471-4159.1999.0721019.x Gustafsen, 2013, Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 33, 64, 10.1523/JNEUROSCI.2371-12.2013 Haining, 2012, The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression, The Journal of Biological Chemistry, 287, 39753, 10.1074/jbc.M112.416503 Haniu, 2000, Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties, The Journal of Biological Chemistry, 275, 21099, 10.1074/jbc.M002095200 Hanus, 2008, Secretory outposts for the local processing of membrane cargo in neuronal dendrites, Traffic, 9, 1437, 10.1111/j.1600-0854.2008.00775.x Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science (New York, NY), 297, 353, 10.1126/science.1072994 Hartmann, 2002, The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts, Human Molecular Genetics, 11, 2615, 10.1093/hmg/11.21.2615 Hasegawa, 2004, Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes, The Journal of Biological Chemistry, 279, 46455, 10.1074/jbc.M406289200 Hattori, 2000, Regulated cleavage of a contact-mediated axon repellent, Science (New York, NY), 289, 1360, 10.1126/science.289.5483.1360 Hayashi, 2004, Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles, The Journal of Biological Chemistry, 279, 38040, 10.1074/jbc.M405597200 Hayashi, 2000, Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction, Science (New York, NY), 287, 2262, 10.1126/science.287.5461.2262 He, 2005, GGA proteins mediate the recycling pathway of memapsin 2 (BACE), The Journal of Biological Chemistry, 280, 11696, 10.1074/jbc.M411296200 Hemler, 2005, Tetraspanin functions and associated microdomains. Nature reviews, Molecular Cell Biology, 6, 801 Herreman, 2003, gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation, Journal of Cell Science, 116, 1127, 10.1242/jcs.00292 Hill, 2003, Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein, The Journal of Biological Chemistry, 278, 36032, 10.1074/jbc.M301632200 Hirst, 1998, Clathrin and adaptors, Biochimica et Biophysica Acta, 1404, 173, 10.1016/S0167-4889(98)00056-1 Ho, 2004, Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage, Proceedings of the National Academy of Sciences of the United States of America, 101, 2548, 10.1073/pnas.0308655100 Hoe, 2007, The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27, 10895, 10.1523/JNEUROSCI.3135-07.2007 Hoe, 2009, Interaction of reelin with amyloid precursor protein promotes neurite outgrowth, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29, 7459, 10.1523/JNEUROSCI.4872-08.2009 Hoe, 2006, DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing, The Journal of Biological Chemistry, 281, 35176, 10.1074/jbc.M602162200 Hollenbeck, 1993, Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport, The Journal of Cell Biology, 121, 305, 10.1083/jcb.121.2.305 Hollenbeck, 2005, The axonal transport of mitochondria, Journal of Cell Science, 118, 5411, 10.1242/jcs.02745 Holsinger, 2002, Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease, Annals of Neurology, 51, 783, 10.1002/ana.10208 Holzbaur, 2010, Axonal transport: CDKs as traffic signals for motor-ists along the axon?, Current Biology: CB, 20, R641, 10.1016/j.cub.2010.06.016 Homayouni, 1999, Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 19, 7507, 10.1523/JNEUROSCI.19-17-07507.1999 Horiuchi, 2007, Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx, Molecular Biology of the Cell, 18, 176, 10.1091/mbc.e06-01-0014 Horton, 2003, Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23, 6188, 10.1523/JNEUROSCI.23-15-06188.2003 Horton, 2004, Secretory trafficking in neuronal dendrites, Nature Cell Biology, 6, 585, 10.1038/ncb0704-585 Horton, 2005, Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis, Neuron, 48, 757, 10.1016/j.neuron.2005.11.005 Hotoda, 2002, A secreted form of human ADAM9 has an alpha-secretase activity for APP, Biochemical and Biophysical Research Communications, 293, 800, 10.1016/S0006-291X(02)00302-9 Hsia, 1999, Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models, Proceedings of the National Academy of Sciences of the United States of America, 96, 3228, 10.1073/pnas.96.6.3228 Hu, 2006, Bace1 modulates myelination in the central and peripheral nervous system, Nature Neuroscience, 9, 1520, 10.1038/nn1797 Hu, 2003, Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex, The Journal of Cell Biology, 161, 685, 10.1083/jcb.200304014 Huang, 2004, Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein, The Journal of Biological Chemistry, 279, 37886, 10.1074/jbc.M402130200 Huppert, 2005, Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation, Developmental Cell, 8, 677, 10.1016/j.devcel.2005.02.019 Huse, 2000, Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase, The Journal of Biological Chemistry, 275, 33729, 10.1074/jbc.M004175200 Hussain, 2000, ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site, Molecular and Cellular Neurosciences, 16, 609, 10.1006/mcne.2000.0884 Iijima, 2000, Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5, Journal of Neurochemistry, 75, 1085, 10.1046/j.1471-4159.2000.0751085.x Innocent, 2012, NMDA receptor/amyloid precursor protein interactions: a comparison between wild-type and amyloid precursor protein mutations associated with familial Alzheimer's disease, Neuroscience Letters, 515, 131, 10.1016/j.neulet.2012.03.029 Inomata, 2003, A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1, The Journal of Biological Chemistry, 278, 22946, 10.1074/jbc.M212160200 Iwatsubo, 2004, [Pathogenesis of Alzheimer's disease: implications from amyloid research front], Rinsho shinkeigaku=Clinical Neurology, 44, 768 Janes, 2005, Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans, Cell, 123, 291, 10.1016/j.cell.2005.08.014 Jeyifous, 2009, SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway, Nature Neuroscience, 12, 1011, 10.1038/nn.2362 Jorissen, 2010, The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30, 4833, 10.1523/JNEUROSCI.5221-09.2010 Kaden, 2008, Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP, The Journal of Biological Chemistry, 283, 7271, 10.1074/jbc.M708046200 Kaether, 2007, Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1, EMBO Reports, 8, 743, 10.1038/sj.embor.7401027 Kamal, 2001, Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP, Nature, 414, 643, 10.1038/414643a Kamenetz, 2003, APP processing and synaptic function, Neuron, 37, 925, 10.1016/S0896-6273(03)00124-7 Kang, 2002, Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis, Cell, 110, 751, 10.1016/S0092-8674(02)00970-4 Kang, 2005, Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling, The Journal of Biological Chemistry, 280, 31537, 10.1074/jbc.M500833200 Kehoe, 1999, A full genome scan for late onset Alzheimer's disease, Human Molecular Genetics, 8, 237, 10.1093/hmg/8.2.237 Kennedy, 2006, Organelles and trafficking machinery for postsynaptic plasticity, Annual Review of Neuroscience, 29, 325, 10.1146/annurev.neuro.29.051605.112808 Kim, 2010, Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10), The Journal of Biological Chemistry, 285, 22919, 10.1074/jbc.M110.126649 Kim, 2003, Regulated hyperaccumulation of presenilin-1 and the “gamma-secretase” complex. Evidence for differential intramembranous processing of transmembrane subatrates, The Journal of Biological Chemistry, 278, 33992, 10.1074/jbc.M305834200 Kim, 2005, Evidence that the “NF” motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2, The Journal of Biological Chemistry, 280, 41953, 10.1074/jbc.M509070200 Kim, 2005, A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1, The Journal of Biological Chemistry, 280, 1992, 10.1074/jbc.M412404200 Kim, 2004, Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway, The Journal of Biological Chemistry, 279, 48615, 10.1074/jbc.C400396200 Kimberly, 2003, Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2, Proceedings of the National Academy of Sciences of the United States of America, 100, 6382, 10.1073/pnas.1037392100 Kins, 2006, Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease, Neuro-degenerative Diseases, 3, 218, 10.1159/000095259 Kitazume, 2001, Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase, Proceedings of the National Academy of Sciences of the United States of America, 98, 13554, 10.1073/pnas.241509198 Koh, 2005, BACE is degraded via the lysosomal pathway, The Journal of Biological Chemistry, 280, 32499, 10.1074/jbc.M506199200 Kojro, 2010, Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis, Journal of Alzheimer's Disease: JAD, 20, 1215, 10.3233/JAD-2010-091621 Kojro, 2001, Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10, Proceedings of the National Academy of Sciences of the United States of America, 98, 5815, 10.1073/pnas.081612998 Kojro, 2006, The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 20, 512, 10.1096/fj.05-4812fje Koo, 1990, Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport, Proceedings of the National Academy of Sciences of the United States of America, 87, 1561, 10.1073/pnas.87.4.1561 Kornilova, 2006, Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking, Biochemistry, 45, 7598, 10.1021/bi060107k Kuhn, 2010, ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons, The EMBO Journal, 29, 3020, 10.1038/emboj.2010.167 Laird, 2005, BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 25, 11693, 10.1523/JNEUROSCI.2766-05.2005 Lalli, 2002, Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR, The Journal of Cell Biology, 156, 233, 10.1083/jcb.200106142 Lammich, 1999, Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease, Proceedings of the National Academy of Sciences of the United States of America, 96, 3922, 10.1073/pnas.96.7.3922 Lanz, 2003, Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype, Neurobiology of Disease, 13, 246, 10.1016/S0969-9961(03)00079-2 Lau, 2007, NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nature reviews, Neuroscience, 8, 413 Lau, 2000, X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains, Molecular and Cellular Neurosciences, 16, 557, 10.1006/mcne.2000.0898 Laudon, 2005, A nine-transmembrane domain topology for presenilin 1, The Journal of Biological Chemistry, 280, 35352, 10.1074/jbc.M507217200 LaVoie, 2003, Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin, The Journal of Biological Chemistry, 278, 37213, 10.1074/jbc.M303941200 Lazarov, 2002, Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, 9785, 10.1523/JNEUROSCI.22-22-09785.2002 Lee, 2010, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations, Cell, 141, 1146, 10.1016/j.cell.2010.05.008 Lee, 2003, APP processing is regulated by cytoplasmic phosphorylation, The Journal of Cell Biology, 163, 83, 10.1083/jcb.200301115 Lee, 2002, Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch, The Journal of Biological Chemistry, 277, 45013, 10.1074/jbc.M208164200 Lee, 2004, A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex, The Journal of Biological Chemistry, 279, 4144, 10.1074/jbc.M309745200 Lefranc-Jullien, 2006, APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages, Journal of Neurochemistry, 97, 807, 10.1111/j.1471-4159.2006.03748.x Levitan, 2001, PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling, Proceedings of the National Academy of Sciences of the United States of America, 98, 12186, 10.1073/pnas.211321898 Levy-Lahad, 1995, Candidate gene for the chromosome 1 familial Alzheimer's disease locus, Science (New York, NY), 269, 973, 10.1126/science.7638622 Li, 2004, A system for enhancing genome-wide coexpression dynamics study, Proceedings of the National Academy of Sciences of the United States of America, 101, 15561, 10.1073/pnas.0402962101 Li, 2004, Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1, The Journal of Biological Chemistry, 279, 10542, 10.1074/jbc.M310001200 Lichtenthaler, 2003, The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1, The Journal of Biological Chemistry, 278, 48713, 10.1074/jbc.M303861200 Lin, 2000, Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein, Proceedings of the National Academy of Sciences of the United States of America, 97, 1456, 10.1073/pnas.97.4.1456 Litterst, 2007, Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor, The Journal of Biological Chemistry, 282, 16155, 10.1074/jbc.M611449200 Loechel, 1998, Human ADAM 12 (meltrin alpha) is an active metalloprotease, The Journal of Biological Chemistry, 273, 16993, 10.1074/jbc.273.27.16993 Loffler, 1992, Beta-amyloid precursor protein isoforms in various rat brain regions and during brain development, Journal of Neurochemistry, 59, 1316, 10.1111/j.1471-4159.1992.tb08443.x Lum, 1998, Intracellular maturation of the mouse metalloprotease disintegrin MDC15, The Journal of Biological Chemistry, 273, 26236, 10.1074/jbc.273.40.26236 Luo, 2003, PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1, The Journal of Biological Chemistry, 278, 7850, 10.1074/jbc.C200648200 Lyckman, 1998, Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system, The Journal of Biological Chemistry, 273, 11100, 10.1074/jbc.273.18.11100 Ma, 2008, A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis, Nature Cell Biology, 10, 283, 10.1038/ncb1690 Malaiyandi, 2005, Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 25, 9507, 10.1523/JNEUROSCI.0868-05.2005 Malenka, 2004, LTP and LTD: an embarrassment of riches, Neuron, 44, 5, 10.1016/j.neuron.2004.09.012 Malinverno, 2010, Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30, 16343, 10.1523/JNEUROSCI.1984-10.2010 Mandelkow, 2004, MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons, The Journal of Cell Biology, 167, 99, 10.1083/jcb.200401085 Marambaud, 2005, Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation, Genes, Brain, and Behavior, 4, 134, 10.1111/j.1601-183X.2005.00086.x Marcello, 2012, Synaptic dysfunction in Alzheimer's disease, Advances in Experimental Medicine and Biology, 970, 573, 10.1007/978-3-7091-0932-8_25 Marcello, 2012, SAP97-mediated local trafficking is altered in Alzheimer disease patients’ hippocampus, Neurobiology of Aging, 33, 10.1016/j.neurobiolaging.2010.09.015 Marcello, 2010, An arginine stretch limits ADAM10 exit from the endoplasmic reticulum, The Journal of Biological Chemistry, 285, 10376, 10.1074/jbc.M109.055947 Marcello, 2007, Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27, 1682, 10.1523/JNEUROSCI.3439-06.2007 Marquez-Sterling, 1997, Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 17, 140, 10.1523/JNEUROSCI.17-01-00140.1997 Matsuda, 2001, c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 21, 6597, 10.1523/JNEUROSCI.21-17-06597.2001 Matsuzaki, 2001, Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons, Nature Neuroscience, 4, 1086, 10.1038/nn736 Matsuzaki, 2004, Structural basis of long-term potentiation in single dendritic spines, Nature, 429, 761, 10.1038/nature02617 Mattson, 2007, Calcium and neurodegeneration, Aging Cell, 6, 337, 10.1111/j.1474-9726.2007.00275.x Maxfield, 2004, Endocytic recycling. Nature reviews, Molecular Cell Biology, 5, 121 McGough, 2011, Recent advances in retromer biology, Traffic, 12, 963, 10.1111/j.1600-0854.2011.01201.x McLoughlin, 1999, Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease, The European Journal of Neuroscience, 11, 1988, 10.1046/j.1460-9568.1999.00610.x Medina, 2003, RIPped out by presenilin-dependent gamma-secretase, Cellular Signalling, 15, 829, 10.1016/S0898-6568(03)00041-X Miller, 2006, The X11 proteins, Abeta production and Alzheimer's disease, Trends in Neurosciences, 29, 280, 10.1016/j.tins.2006.03.001 Minopoli, 2007, Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage, The Journal of Biological Chemistry, 282, 831, 10.1074/jbc.C600276200 Momiyama, 2003, The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats, The Journal of Physiology, 549, 75, 10.1113/jphysiol.2002.033472 Morais, 2003, The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex, The Journal of Biological Chemistry, 278, 43284, 10.1074/jbc.M305685200 Morfini, 2004, A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons, The EMBO Journal, 23, 2235, 10.1038/sj.emboj.7600237 Morfini, 2009, Axonal transport defects in neurodegenerative diseases, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29, 12776, 10.1523/JNEUROSCI.3463-09.2009 Moss, 2004, Therapeutic benefits from targeting of ADAM family members, Biochemistry, 43, 7227, 10.1021/bi049677f Moss, 2007, The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events, The Journal of Biological Chemistry, 282, 35712, 10.1074/jbc.M703231200 Muresan, 2005, Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1, The Journal of Cell Biology, 171, 615, 10.1083/jcb.200502043 Nakagawa, 1998, Neural crest emigration from the neural tube depends on regulated cadherin expression, Development, 125, 2963, 10.1242/dev.125.15.2963 Nakaya, 2001, Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug, Genes to Cells: Devoted to Molecular & Cellular Mechanisms, 6, 43, 10.1046/j.1365-2443.2001.00397.x Nakaya, 2006, Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD, Genes to Cells: Devoted to Molecular & Cellular Mechanisms, 11, 633, 10.1111/j.1365-2443.2006.00968.x Naruse, 1998, Effects of PS1 deficiency on membrane protein trafficking in neurons, Neuron, 21, 1213, 10.1016/S0896-6273(00)80637-6 Naumann, 2010, Transgenic expression of human wild-type amyloid precursor protein decreases neurogenesis in the adult hippocampus, Hippocampus, 20, 971 Newpher, 2008, Glutamate receptor dynamics in dendritic microdomains, Neuron, 58, 472, 10.1016/j.neuron.2008.04.030 Ng, 2008, Gamma-secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 22, 2832, 10.1096/fj.07-103903 Niimura, 2005, Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions, The Journal of Biological Chemistry, 280, 12967, 10.1074/jbc.M409829200 Nixon, 2005, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study, Journal of Neuropathology and Experimental Neurology, 64, 113, 10.1093/jnen/64.2.113 Nordstedt, 1993, Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells, The Journal of Biological Chemistry, 268, 608, 10.1016/S0021-9258(18)54194-6 Nusser, 1998, Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus, Neuron, 21, 545, 10.1016/S0896-6273(00)80565-6 Nyabi, 2003, Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin, The Journal of Biological Chemistry, 278, 43430, 10.1074/jbc.M306957200 Oddo, 2003, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction, Neuron, 39, 409, 10.1016/S0896-6273(03)00434-3 Oh, 2005, Topology of the C-terminal fragment of human presenilin 1, Biochemistry, 44, 11821, 10.1021/bi0509494 Okabe, 2007, Molecular anatomy of the postsynaptic density, Molecular and Cellular Neurosciences, 34, 503, 10.1016/j.mcn.2007.01.006 Okada, 2010, Proteomic identification of sorting nexin 6as a negative regulator of BACE1-mediated APP processing, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 24, 2783, 10.1096/fj.09-146357 Okamoto, 1997, Mints, Munc18-interacting proteins in synaptic vesicle exocytosis, The Journal of Biological Chemistry, 272, 31459, 10.1074/jbc.272.50.31459 Okamoto, 1998, Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2, European Journal of Cell Biology, 77, 161, 10.1016/S0171-9335(98)80103-9 Olry, 2005, Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein, The Journal of Biological Chemistry, 280, 28564, 10.1074/jbc.M502199200 Ono, 1997, Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP), Journal of Biochemistry, 121, 585, 10.1093/oxfordjournals.jbchem.a021625 Osterfield, 2008, Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system, Development, 135, 1189, 10.1242/dev.007401 Padovani, 2001, Amyloid precursor protein in platelets: a peripheral marker for the diagnosis of sporadic AD, Neurology, 57, 2243, 10.1212/WNL.57.12.2243 Palay, 1955, The fine structure of neurons, The Journal of Biophysical and Biochemical Cytology, 1, 69, 10.1083/jcb.1.1.69 Paradies, 1993, Purification and characterization of NCAD90, a soluble endogenous form of N-cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite-promoting function, Journal of Neuroscience Research, 36, 33, 10.1002/jnr.490360105 Parent, 1999, Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1, Neurobiology of Disease, 6, 56, 10.1006/nbdi.1998.0207 Park, 2004, Recycling endosomes supply AMPA receptors for LTP, Science (New York, NY), 305, 1972, 10.1126/science.1102026 Park, 2006, Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes, Neuron, 52, 817, 10.1016/j.neuron.2006.09.040 Parkin, 2004, Dual mechanisms for shedding of the cellular prion protein, The Journal of Biological Chemistry, 279, 11170, 10.1074/jbc.M312105200 Parton, 1992, Axonal and dendritic endocytic pathways in cultured neurons, The Journal of Cell Biology, 119, 123, 10.1083/jcb.119.1.123 Pastorino, 2006, The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production, Nature, 440, 528, 10.1038/nature04543 Perez, 1996, Enhanced release of amyloid beta-protein from codon 670/671 “Swedish” mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways, The Journal of Biological Chemistry, 271, 9100, 10.1074/jbc.271.15.9100 Pitsi, 2004, Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity, The Journal of Biological Chemistry, 279, 25333, 10.1074/jbc.M312710200 Postina, 2004, A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model, The Journal of Clinical Investigation, 113, 1456, 10.1172/JCI20864 Pow, 1989, Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis, Neuroscience, 32, 435, 10.1016/0306-4522(89)90091-2 Prinzen, 2005, Genomic structure and functional characterization of the human ADAM10 promoter, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 19, 1522, 10.1096/fj.04-3619fje Prokop, 2005, Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments, Journal of Neurochemistry, 94, 57, 10.1111/j.1471-4159.2005.03165.x Prokop, 2004, Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex, The Journal of Biological Chemistry, 279, 23255, 10.1074/jbc.M401789200 Racca, 2000, NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 20, 2512, 10.1523/JNEUROSCI.20-07-02512.2000 Raemaekers, 2005, Presenilin 1: more than just gamma-secretase, Biochemical Society Transactions, 33, 559, 10.1042/BST0330559 Rao, 2001, Visualization of neuropeptide expression, transport, and exocytosis in Drosophila melanogaster, Journal of Neurobiology, 49, 159, 10.1002/neu.1072 Ratner, 1998, A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 18, 7717, 10.1523/JNEUROSCI.18-19-07717.1998 Rechards, 2006, Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments, Traffic, 7, 354, 10.1111/j.1600-0854.2006.00388.x Reiss, 2005, ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling, The EMBO Journal, 24, 742, 10.1038/sj.emboj.7600548 Ris, 2003, Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1, The Journal of Biological Chemistry, 278, 44393, 10.1074/jbc.M300971200 Rockenstein, 2005, High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease, The Journal of Biological Chemistry, 280, 32957, 10.1074/jbc.M507016200 Rogaev, 1995, Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene, Nature, 376, 775, 10.1038/376775a0 Rogaeva, 2007, Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene, The Journal of Biological Chemistry, 282, 20897, 10.1074/jbc.M610038200 Rogelj, 2006, The X11/Mint family of adaptor proteins, Brain Research Reviews, 52, 305, 10.1016/j.brainresrev.2006.04.005 Roghani, 1999, Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity, The Journal of Biological Chemistry, 274, 3531, 10.1074/jbc.274.6.3531 Rossner, 2005, Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme, Journal of Neurochemistry, 92, 226, 10.1111/j.1471-4159.2004.02857.x Sabo, 1999, Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein, The Journal of Biological Chemistry, 274, 7952, 10.1074/jbc.274.12.7952 Saito, 2005, Identification and characterization of a novel human APH-1b splice variant lacking exon 4, Biochemical and Biophysical Research Communications, 330, 1068, 10.1016/j.bbrc.2005.03.096 Sambamurti, 1999, Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein, The Journal of Biological Chemistry, 274, 26810, 10.1074/jbc.274.38.26810 Sankaranarayanan, 2008, In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1, The Journal of Pharmacology and Experimental Therapeutics, 324, 957, 10.1124/jpet.107.130039 Sano, 2006, Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP, PloS One, 1, e51, 10.1371/journal.pone.0000051 Saura, 2004, Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration, Neuron, 42, 23, 10.1016/S0896-6273(04)00182-5 Schafer, 1995, Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin, The EMBO Journal, 14, 2424, 10.1002/j.1460-2075.1995.tb07240.x Scheinfeld, 2002, NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP), The Journal of Biological Chemistry, 277, 3767, 10.1074/jbc.M108357200 Schroeter, 2003, A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis, Proceedings of the National Academy of Sciences of the United States of America, 100, 13075, 10.1073/pnas.1735338100 Seaman, 2004, Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer, The Journal of Cell Biology, 165, 111, 10.1083/jcb.200312034 Selkoe, 2003, Notch and presenilin: regulated intramembrane proteolysis links development and degeneration, Annual Review of Neuroscience, 26, 565, 10.1146/annurev.neuro.26.041002.131334 Selkoe, 2001, Alzheimer's disease: genes, proteins, and therapy, Physiological Reviews, 81, 741, 10.1152/physrev.2001.81.2.741 Selkoe, 2001, Presenilin, Notch, and the genesis and treatment of Alzheimer's disease, Proceedings of the National Academy of Sciences of the United States of America, 98, 11039, 10.1073/pnas.211352598 Selkoe, 2007, Presenilin: running with scissors in the membrane, Cell, 131, 215, 10.1016/j.cell.2007.10.012 Shah, 2005, Nicastrin functions as a gamma-secretase-substrate receptor, Cell, 122, 435, 10.1016/j.cell.2005.05.022 Sharples, 2008, Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 22, 1469, 10.1096/fj.07-9357com Shen, 2007, The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism, Proceedings of the National Academy of Sciences of the United States of America, 104, 403, 10.1073/pnas.0608332104 Sheng, 2007, The postsynaptic architecture of excitatory synapses: a more quantitative view, Annual Review of Biochemistry, 76, 823, 10.1146/annurev.biochem.76.060805.160029 Shepherd, 2007, The cell biology of synaptic plasticity: AMPA receptor trafficking, Annual Review of Cell and Developmental Biology, 23, 613, 10.1146/annurev.cellbio.23.090506.123516 Sherrington, 1995, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature, 375, 754, 10.1038/375754a0 Shi, 1999, Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation, Science (New York, NY), 284, 1811, 10.1126/science.284.5421.1811 Shi, 2001, The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain, The Journal of Biological Chemistry, 276, 10366, 10.1074/jbc.M009200200 Shi, 2003, Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity, The Journal of Biological Chemistry, 278, 21286, 10.1074/jbc.M209859200 Shiraishi, 2004, PEN-2 enhances gamma-cleavage after presenilin heterodimer formation, Journal of Neurochemistry, 90, 1402, 10.1111/j.1471-4159.2004.02597.x Shirotani, 2003, Gamma-secretase activity is associated with a conformational change of nicastrin, The Journal of Biological Chemistry, 278, 16474, 10.1074/jbc.C300095200 Siemes, 2006, Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro, Experimental Cell Research, 312, 1939, 10.1016/j.yexcr.2006.02.025 Simons, 1996, Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 16, 899, 10.1523/JNEUROSCI.16-03-00899.1996 Simons, 1995, Intracellular routing of human amyloid protein precursor: axonal delivery followed by transport to the dendrites, Journal of Neuroscience Research, 41, 121, 10.1002/jnr.490410114 Sinha, 1999, Purification and cloning of amyloid precursor protein beta-secretase from human brain, Nature, 402, 537, 10.1038/990114 Sinha, 1991, Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor, The Journal of Biological Chemistry, 266, 21011, 10.1016/S0021-9258(18)54812-2 Sisodia, 1990, Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing, Science (New York, NY), 248, 492, 10.1126/science.1691865 Small, 2006, Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis, Neuron, 52, 15, 10.1016/j.neuron.2006.09.001 Small, 2005, Model-guided microarray implicates the retromer complex in Alzheimer's disease, Annals of Neurology, 58, 909, 10.1002/ana.20667 Small, S.A., Peirce, A.L., Kent, K., Leung, C., Honig, L., Vonsattel, J.P., 2003. Combining functional imaging with microarray; identifying an unexplored cellular pathway implicated in sporadic Alzheimer's disease. In: Annual Meeting of the Society for Neuroscience, New Orleans. Smith, 2005, Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals, Cell Calcium, 38, 427, 10.1016/j.ceca.2005.06.021 Soba, 2005, Homo- and heterodimerization of APP family members promotes intercellular adhesion, The EMBO Journal, 24, 3624, 10.1038/sj.emboj.7600824 Solans, 2000, A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase, Cytogenetics and Cell Genetics, 89, 177, 10.1159/000015608 Soriano, 1999, Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments, The Journal of Biological Chemistry, 274, 32295, 10.1074/jbc.274.45.32295 Soriano, 2001, Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing, The Journal of Cell Biology, 152, 785, 10.1083/jcb.152.4.785 Spacek, 1997, Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 17, 190, 10.1523/JNEUROSCI.17-01-00190.1997 Spacek, 1998, Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus, The Journal of Comparative Neurology, 393, 58, 10.1002/(SICI)1096-9861(19980330)393:1<58::AID-CNE6>3.0.CO;2-P Spasic, 2007, Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway, The Journal of Cell Biology, 176, 629, 10.1083/jcb.200609180 Spasic, 2006, Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway, The Journal of Biological Chemistry, 281, 26569, 10.1074/jbc.M600592200 Spires-Jones, 2007, Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model, The American Journal of Pathology, 171, 1304, 10.2353/ajpath.2007.070055 Sprecher, 1993, Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family, Biochemistry, 32, 4481, 10.1021/bi00068a002 Steiner, 1998, Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation, The Journal of Biological Chemistry, 273, 32322, 10.1074/jbc.273.48.32322 Steiner, 2000, Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases, Nature Cell Biology, 2, 848, 10.1038/35041097 Steiner, 1999, Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis, Biochemistry, 38, 14600, 10.1021/bi9914210 Steiner, 2002, PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin, The Journal of Biological Chemistry, 277, 39062, 10.1074/jbc.C200469200 Steuble, 2012, Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport, Biology Open, 1, 761, 10.1242/bio.20121578 Stutzmann, 2004, Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 24, 508, 10.1523/JNEUROSCI.4386-03.2004 Suh, 2011, FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing, Journal of Neurochemistry, 119, 377, 10.1111/j.1471-4159.2011.07419.x Suzuki, 2012, Activity-dependent proteolytic cleavage of neuroligin-1, Neuron, 76, 410, 10.1016/j.neuron.2012.10.003 Suzuki, 1994, Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein, The EMBO Journal, 13, 1114, 10.1002/j.1460-2075.1994.tb06360.x Takasugi, 2003, The role of presenilin cofactors in the gamma-secretase complex, Nature, 422, 438, 10.1038/nature01506 Tampellini, 2009, Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29, 9704, 10.1523/JNEUROSCI.2292-09.2009 Tanahashi, 1999, Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein, Neuroscience Letters, 261, 143, 10.1016/S0304-3940(98)00995-1 Tanaka, 2005, Number and density of AMPA receptors in single synapses in immature cerebellum, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 25, 799, 10.1523/JNEUROSCI.4256-04.2005 Taru, 2002, Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism, The Journal of Biological Chemistry, 277, 27567, 10.1074/jbc.M203713200 Taru, 2004, Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein, The Journal of Biological Chemistry, 279, 21628, 10.1074/jbc.M312007200 Terasaki, 1994, Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons, Proceedings of the National Academy of Sciences of the United States of America, 91, 7510, 10.1073/pnas.91.16.7510 Thinakaran, 1996, Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo, Neuron, 17, 181, 10.1016/S0896-6273(00)80291-3 Thinakaran, 2004, Identification of the role of presenilins beyond Alzheimer's disease, Pharmacological Research: The Official Journal of the Italian Pharmacological Society, 50, 411, 10.1016/j.phrs.2003.12.026 Tian, 2002, Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines, The Journal of Biological Chemistry, 277, 31499, 10.1074/jbc.M112328200 Tippmann, 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 23, 1643, 10.1096/fj.08-121392 Tomita, 1999, Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein, The Journal of Biological Chemistry, 274, 2243, 10.1074/jbc.274.4.2243 Toresson, 2005, Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines, The European Journal of Neuroscience, 22, 1793, 10.1111/j.1460-9568.2005.04342.x Traub, 2005, Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane, Biochimica et Biophysica Acta, 1744, 415, 10.1016/j.bbamcr.2005.04.005 Tu, 2006, Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations, Cell, 126, 981, 10.1016/j.cell.2006.06.059 Tun, 2002, Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway, Journal of Molecular Neuroscience: MN, 19, 31, 10.1007/s12031-002-0007-5 Tyler, 2002, Alpha- and beta-secretase: profound changes in Alzheimer's disease, Biochemical and Biophysical Research Communications, 299, 373, 10.1016/S0006-291X(02)02635-9 Uemura, 2006, Characterization of sequential N-cadherin cleavage by ADAM10 and PS1, Neuroscience Letters, 402, 278, 10.1016/j.neulet.2006.04.018 Vassar, 1999, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science (New York, NY), 286, 735, 10.1126/science.286.5440.735 Verges, 2004, The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor, Nature Cell Biology, 6, 763, 10.1038/ncb1153 Verhey, 2001, Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules, The Journal of Cell Biology, 152, 959, 10.1083/jcb.152.5.959 Verkhratsky, 2002, The endoplasmic reticulum and neuronal calcium signalling, Cell Calcium, 32, 393, 10.1016/S0143416002001896 Verkhratsky, 2005, Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons, Physiological Reviews, 85, 201, 10.1152/physrev.00004.2004 Vetrivel, 2007, Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism, Molecular Neurodegeneration, 2, 4, 10.1186/1750-1326-2-4 Vincent, 2004, ADAM proteases: protective role in Alzheimer's and prion diseases?, Current Alzheimer Research, 1, 165, 10.2174/1567205043332072 von Arnim, 2005, The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate, The Journal of Biological Chemistry, 280, 17777, 10.1074/jbc.M414248200 Walsh, 2002, Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, 535, 10.1038/416535a Walter, 2001, Phosphorylation regulates intracellular trafficking of beta-secretase, The Journal of Biological Chemistry, 276, 14634, 10.1074/jbc.M011116200 Wan, 2012, Activation of NMDA receptors upregulates a disintegrin and metalloproteinase 10 via a Wnt/MAPK signaling pathway, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 32, 3910, 10.1523/JNEUROSCI.3916-11.2012 Wang, 2004, Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components, The Journal of Biological Chemistry, 279, 40560, 10.1074/jbc.M404345200 Wang, 2006, C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation, Journal of Neurochemistry, 96, 218, 10.1111/j.1471-4159.2005.03548.x Wang, 2006, Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation, Proceedings of the National Academy of Sciences of the United States of America, 103, 353, 10.1073/pnas.0509822102 Wang, 2004, The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain, Molecular Cell, 15, 343, 10.1016/j.molcel.2004.06.037 Wang, 2009, Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29, 10788, 10.1523/JNEUROSCI.2132-09.2009 Wei, 2010, Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13, 190, 10.1038/nn.2476 Weskamp, 1996, MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains, The Journal of Cell Biology, 717, 10.1083/jcb.132.4.717 Willem, 2006, Control of peripheral nerve myelination by the beta-secretase BACE1, Science (New York, NY), 314, 664, 10.1126/science.1132341 Winckler, 1999, Neuronal polarity: controlling the sorting and diffusion of membrane components, Neuron, 23, 637, 10.1016/S0896-6273(01)80021-0 Wolfe, 1999, Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity, Nature, 398, 513, 10.1038/19077 Wolfsberg, 1995, ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain, Developmental Biology, 169, 378, 10.1006/dbio.1995.1152 Wong, 2005, beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase, The Journal of Biological Chemistry, 280, 23009, 10.1074/jbc.M414648200 Wrigley, 2004, Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding, Journal of Neurochemistry, 90, 1312, 10.1111/j.1471-4159.2004.02596.x Xia, 2000, Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation, Proceedings of the National Academy of Sciences of the United States of America, 97, 9299, 10.1073/pnas.97.16.9299 Xu, 2009, Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 23, 3674, 10.1096/fj.09-133462 Yamazaki, 1995, Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons, The Journal of Cell Biology, 129, 431, 10.1083/jcb.129.2.431 Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity, Nature, 402, 533, 10.1038/990107 Yan, 2001, The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate, The Journal of Biological Chemistry, 276, 36788, 10.1074/jbc.M104350200 Yang, 2008, Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease, The American Journal of Pathology, 173, 665, 10.2353/ajpath.2008.071176 Yang, 2003, Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease, Nature Medicine, 9, 3, 10.1038/nm0103-3 Yoo, 2000, Presenilin-mediated modulation of capacitative calcium entry, Neuron, 27, 561, 10.1016/S0896-6273(00)00066-0 Young-Pearse, 2007, A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27, 14459, 10.1523/JNEUROSCI.4701-07.2007 Yu, 2000, Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing, Nature, 407, 48, 10.1038/35024009 Zambrano, 1997, Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins, The Journal of Biological Chemistry, 272, 6399, 10.1074/jbc.272.10.6399 Zatti, 2006, Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels, Cell Calcium, 39, 539, 10.1016/j.ceca.2006.03.002 Zhang, 2009, Presenilins are essential for regulating neurotransmitter release, Nature, 460, 632, 10.1038/nature08177 Zhang, 2005, Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2, Biochemistry, 44, 4450, 10.1021/bi0481500 Zheng, 2006, The amyloid precursor protein: beyond amyloid, Molecular Neurodegeneration, 1, 5, 10.1186/1750-1326-1-5 Zimmermann, 2004, Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines, Journal of Neurochemistry, 90, 1489, 10.1111/j.1471-4159.2004.02680.x