Toxocara “omics” and the promises it holds for medicine and veterinary medicine

Abete-Luzi, 2018, Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29, Genesis, 56, 1, 10.1002/dvg.23106 Au, 2019, CRISPR/Cas9 methodology for the generation of knockout deletions in Caenorhabditis elegans, G3 (Bethesda), 9, 135, 10.1534/g3.118.200778 Bjorkhem, 2004, Brain cholesterol: long secret life behind a barrier, Arterioscler. Thromb. Vasc. Biol., 24, 806, 10.1161/01.ATV.0000120374.59826.1b Bourgard, 2018, Plasmodium vivax biology: insights provided by genomics, transcriptomics and proteomics, Front. Cell. Infect. Microbiol., 8, 34, 10.3389/fcimb.2018.00034 Britton, 2014, microRNAs of parasitic helminths—identification, characterization and potential as drug targets, Int. J. Parasitol. Drugs Drug Resist., 24, 85, 10.1016/j.ijpddr.2014.03.001 Buck, 2014, Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity, Nat. Commun., 5, 5488, 10.1038/ncomms6488 Chen, 2018, Toxocariasis: a silent threat with a progressive public health impact, Infect. Dis. Poverty, 7, 59, 10.1186/s40249-018-0437-0 Chuan, 2010, Our wormy world genomics, proteomics and transcriptomics in east and southeast Asia, Adv. Parasitol., 73, 327 Crook, 2014, The dauer hypothesis and the evolution of parasitism: 20 years on and still going strong, Int. J. Parasitol., 44, 1, 10.1016/j.ijpara.2013.08.004 Cross, 2016, Exploring the molecular mechanisms of parasite-host interactions with a view towards new therapeutics and vaccines, Postepy Biochem., 62, 370, 10.18388/pb.2016_40 Cwiklinski, 2018, Advances in fasciola hepatica research using 'omics' technologies, Int. J. Parasitol., 48, 321, 10.1016/j.ijpara.2017.12.001 da Silva, 2018, The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics, Vet. Parasitol., 259, 25, 10.1016/j.vetpar.2018.06.015 Daniels, 2000, Egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues, Genetics, 156, 123, 10.1093/genetics/156.1.123 Devaney, 2010, microRNAs: a role in drug resistance in parasitic nematodes?, Trends Parasitol., 26, 428, 10.1016/j.pt.2010.05.003 Eneqvist, 2003, The transthyretin-related protein family, Eur. J. Biochem., 270, 518, 10.1046/j.1432-1033.2003.03408.x Epe, 1994, The behavior and pathogenicity of Toxocara canis larvae in mice of different strains, Parasitol. Res., 80, 691, 10.1007/BF00932955 Fakhri, 2018, Toxocara eggs in public places worldwide—a systematic review and meta-analysis, Environ. Pollut., 242, 1467, 10.1016/j.envpol.2018.07.087 Ferreira, 2004, Role of calreticulin from parasites in its interaction with vertebrate hosts, Mol. Immunol., 40, 1279, 10.1016/j.molimm.2003.11.018 Forrester, 2004, Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni, Mol. Biochem. Parasitol., 136, 149, 10.1016/j.molbiopara.2004.03.007 Gasser, 2016, Harnessing the Toxocara genome to underpin Toxocariasis research and new interventions, Adv. Parasitol., 91, 87, 10.1016/bs.apar.2015.12.001 2016, Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, Lancet, 388, 1545, 10.1016/S0140-6736(16)31678-6 Gems, 1995, An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26-kDa protein with homology to phosphatidylethanolamine-binding proteins, J. Biol. Chem., 270, 18517, 10.1074/jbc.270.31.18517 Hofmann, 2010, Parasite annexins—new molecules with potential for drug and vaccine development, Bioessays, 32, 967, 10.1002/bies.200900195 Hoogstrate, 2014, Nematode endogenous small RNA pathways, Worm, 3, 10.4161/worm.28234 Hoppe, 2010, Caenorhabditis elegans unc-82 encodes a serine/threonine kinase important for myosin filament organization in muscle during growth, Genetics, 184, 79, 10.1534/genetics.109.110189 Howe, 2016, WormBase 2016: expanding to enable helminth genomic research, Nucleic Acids Res., 44, D774, 10.1093/nar/gkv1217 Hu, 2007, Trichostrongylus vitrinus (Nematoda: Strongylida): molecular characterization and transcriptional analysis of Tv-stp-1, a serine/threonine phosphatase gene, Exp. Parasitol., 117, 22, 10.1016/j.exppara.2007.03.008 International Helminth Genomes Consortium, 2019, Comparative genomics of the major parasitic worms, Nat. Genet., 51, 163, 10.1038/s41588-018-0262-1 Janecek, 2014, Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse, Parasit. Vectors, 7, 194, 10.1186/1756-3305-7-194 Janecek, 2015, Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes, Int. J. Parasitol., 45, 495, 10.1016/j.ijpara.2015.02.009 Jex, 2011, Ascaris suum draft genome, Nature, 479, 529, 10.1038/nature10553 Joachim, 2011, Prostaglandin D (2) synthesis in Oesophagostomum dentatum is mediated by cytosolic glutathione S-transferase, Exp. Parasitol., 127, 604, 10.1016/j.exppara.2010.10.020 Kim, 2013, Comparison of functional gene annotation of Toxascaris leonina and Toxocara canis using CLC genomics workbench, Korean J. Parasitol., 51, 525, 10.3347/kjp.2013.51.5.525 Klumpp, 2002, Serine/threonine protein phosphatases in apoptosis, Curr. Opin. Pharmacol., 2, 458, 10.1016/S1471-4892(02)00176-5 Kong, 2016, Draft genome of Toxocara canis, a pathogen responsible for visceral larva migrans, Korean J. Parasitol., 54, 751, 10.3347/kjp.2016.54.6.751 Kotagama, 2019, ALG-1 influences accurate mRNA splicing patterns in the Caenorhabditis elegans intestine and body muscle tissues by modulating splicing factor activities, Genetics, 212, 931, 10.1534/genetics.119.302223 Lalaouna, 2014, Regulatory RNAs involved in bacterial antibiotic resistance, PLoS Pathog., 28 Liu, 2019, Protective effect against toxoplasmosis in BALB/c mice vaccinated with Toxoplasma gondii macrophage migration inhibitory factor, Front. Microbiol., 10, 813, 10.3389/fmicb.2019.00813 Loukas, 1999, A novel C-type lectin secreted by a tissue-dwelling parasitic nematode, Curr. Biol., 9, 825, 10.1016/S0960-9822(99)80366-2 Loukas, 2000, Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis, which binds to host ligands, Parasitology, 121, 545, 10.1017/S0031182099006721 Ma, 2014, Molecular characterization and functional analysis of serine/threonine protein phosphatase of Toxocara canis, Exp. Parasitol., 141, 55, 10.1016/j.exppara.2014.03.019 Ma, 2015, Molecular mechanism of serine/threonine protein phosphatase 1 (PP1cα-PP1r7) in spermatogenesis of Toxocara canis, Acta Trop., 149, 148, 10.1016/j.actatropica.2015.05.026 Ma, 2016, MicroRNAs of Toxocara canis and their predicted functional roles, Parasit. Vectors, 9, 229, 10.1186/s13071-016-1508-3 Ma, 2018, Human toxocariasis, Lancet Infect. Dis., 18, e14, 10.1016/S1473-3099(17)30331-6 Ma, 2019, Aquaporin 1 is located on the intestinal basolateral membrane in Toxocara canis and might play a role in drug uptake, Parasit. Vectors, 12, 243, 10.1186/s13071-019-3500-1 Ma, 2019, Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host, Parasit. Vectors, 12, 32, 10.1186/s13071-018-3265-y Maizels, 2007, Regulation of the immune system in metazoan parasite infections, Novartis Found. Symp., 281, 192, 10.1002/9780470062128.ch16 Maizels, 2013, Toxocara canis: molecular basis of immune recognition and evasion, Vet. Parasitol., 193, 365, 10.1016/j.vetpar.2012.12.032 Maizels, 1993, Immunological modulation and evasion by helminth parasites in human populations, Nature, 365, 797, 10.1038/365797a0 Maizels, 2000, Toxocara canis: genes expressed by the arrested infective larval stage of a parasitic nematode, Int. J. Parasitol., 30, 495, 10.1016/S0020-7519(00)00022-9 Massone, 2007, Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells, Biochem. Biophys. Res. Commun., 362, 633, 10.1016/j.bbrc.2007.08.061 Page, 2014, Enzymology of the nematode cuticle: a potential drug target?, Int. J. Parasitol. Drugs Drug Resist., 4, 133, 10.1016/j.ijpddr.2014.05.003 Park, 2009, Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment, J. Immunol., 182, 6907, 10.4049/jimmunol.0803533 Peixoto, 2000, Ultrastructural analyses of the Caenorhabditis elegans sqt-1(sc13) left roller mutant, J. Parasitol., 86, 269, 10.1645/0022-3395(2000)086[0269:UAOTCE]2.0.CO;2 Perez-Morales, 2015, The role of small heat shock proteins in parasites, Cell Stress Chaperones, 20, 767, 10.1007/s12192-015-0607-y Poulsen, 2015, Differential serodiagnostics of Toxocara canis and Toxocara cati—is it possible?, Parasite Immunol., 37, 204, 10.1111/pim.12181 Prichard, 2007, ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development, Parasitology, 134, 1123, 10.1017/S0031182007000091 Rao, 2009, A dopamine-gated ion channel (HcGGR3*) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance, Mol. Biochem. Parasitol., 166, 54, 10.1016/j.molbiopara.2009.02.011 Rostami, 2019, Human toxocariasis—a look at a neglected disease through an epidemiological ‘prism, Infect. Genet. Evol., 74, 104002, 10.1016/j.meegid.2019.104002 Sarkies, 2015, Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages, PLoS Biol., 13, 10.1371/journal.pbio.1002061 Schulz, 2018, Preventive chemotherapy in the fight against soil-transmitted helminthiasis: achievements and limitations, Trends Parasitol., 34, 590, 10.1016/j.pt.2018.04.008 Sperotto, 2017, Proteomic analysis of Toxocara canis excretory and secretory (TES) proteins, Mol. Biochem. Parasitol., 211, 39, 10.1016/j.molbiopara.2016.09.002 Staudacher, 2015, Mucin-type O-glycosylation in invertebrates, Molecules, 20, 10622, 10.3390/molecules200610622 Stavitsky, 2003, Blockade of macrophage migration inhibitory factor (MIF) in Schistosoma japonicum-infected mice results in an increased adult worm burden and reduced fecundity, Parasite Immunol., 25, 369, 10.1046/j.1365-3024.2003.00641.x Stoltzfus, 2017, Perusal of parasitic nematode “omics” in the post-genomic era, Mol. Biochem. Parasitol., 215, 11, 10.1016/j.molbiopara.2016.11.003 Stroehlein, 2016, CAP protein superfamily members in Toxocara canis, Parasit. Vectors, 9, 360, 10.1186/s13071-016-1642-y Strube, 2013, Toxocara spp. infections in paratenic hosts, Vet. Parasitol., 193, 375, 10.1016/j.vetpar.2012.12.033 Tetteh, 1999, Identification of abundantly expressed novel and conserved genes from the infective larval stage of Toxocara canis by an expressed sequence tag strategy, Infect. Immun., 67, 4771, 10.1128/IAI.67.9.4771-4779.1999 Thacker, 2006, Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase, Cell. Mol. Life Sci., 63, 1193, 10.1007/s00018-006-6012-z Turner, 2008, Characterization of a galectin-like activity from the parasitic nematode, Haemonchus contortus, which modulates ovine eosinophil migration in vitro, Vet. Immunol. Immunopathol., 122, 138, 10.1016/j.vetimm.2007.11.002 Twu, 2014, Parasite extracellular vesicles: mediators of intercellular communication, PLoS Pathog., 10, 10.1371/journal.ppat.1004289 Varghese, 2017, Sero-detection of Toxocara canis infection in human with T. canis recombinant arginine kinase, cathepsin L-1 and TES-26 antigens, Acta Parasitol., 62, 775, 10.1515/ap-2017-0093 Vercauteren, 2003, Identification of excretory-secretory products of larval and adult Ostertagia ostertagi by immunoscreening of cDNA libraries, Mol. Biochem. Parasitol., 126, 201, 10.1016/S0166-6851(02)00274-8 Wang, 2011, Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles, Genome Res., 21, 1462, 10.1101/gr.121426.111 Wang, 2017, Comparative genome analysis of programmed DNA elimination in nematodes, Genome Res., 27, 2001, 10.1101/gr.225730.117 Wang, 2017, Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Haemonchus contortus acting at the parasite-host cell interface, Oncotarget, 8, 40052, 10.18632/oncotarget.16675 Williamson, 2003, Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules, Parasitology, 126, 179, 10.1017/S0031182002002706 Williamson, 2009, The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits, PLoS Pathog., 5, 10.1371/journal.ppat.1000517 World Health Organization Zelck, 2004, Antioxidant enzymes in intramolluscan Schistosoma mansoni and ROS-induced changes in expression, Parasitology, 128, 493, 10.1017/S0031182004004895 Zheng, 2013, MicroRNAs in parasites and parasite infection, RNA Biol., 10, 371, 10.4161/rna.23716 Zhou, 2011, Construction of a cDNA library from female adult of Toxocara canis, and analysis of EST and immune-related genes expressions, Exp. Parasitol., 129, 120, 10.1016/j.exppara.2011.07.005 Zhou, 2017, Comparative transcriptomic analyses of male and female adult Toxocara canis, Gene, 600, 85, 10.1016/j.gene.2016.11.024 Zhu, 2015, Genetic blueprint of the zoonotic pathogen Toxocara canis, Nat. Commun., 6, 6145, 10.1038/ncomms7145