Toxicity of fluoroquinolone antibiotics to aquatic organisms
Tóm tắt
Toxicity tests were performed with seven fluoroquinolone antibiotics, ciprofloxacin, lomefloxacin, ofloxacin, levofloxacin, clinafloxacin, enrofloxacin, and flumequine, on five aquatic organisms. Overall toxicity values ranged from 7.9 to 23,000 μg/L. The cyanobacterium Microcystis aeruginosa was the most sensitive organism (5-d growth and reproduction, effective concentrations [EC50s] ranging from 7.9 to 1,960 μg/L and a median of 49 μg/L), followed by duckweed (Lemna minor, 7-d reproduction, EC50 values ranged from 53 to 2,470 μg/L with a median of 106 μg/L) and the green alga Pseudokirchneriella subcapitata (3-d growth and reproduction, EC50 values ranged from 1,100 to 22,700 μg/L with a median 7,400 μg/L). Results from tests with the crustacean Daphnia magna (48-h survival) and fathead minnow (Pimephales promelas, 7-d early life stage survival and growth) showed limited toxicity with no-observed-effect concentrations at or near 10 mg/L. Fish dry weights obtained in the ciprofloxacin, levofloxacin, and ofloxacin treatments (10 mg/L) were significantly higher than in control fish. The hazard of adverse effects occurring to the tested organisms in the environment was quantified by using hazard quotients. An estimated environmental concentration of 1 μg/L was chosen based on measured environmental concentrations previously reported in surface water; at this level, only M. aeruginosa may be at risk in surface water. However, the selective toxicity of these compounds may have implications for aquatic community structure.
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Tài liệu tham khảo
Appelbaum, 1995, Quinolone activity against anaerobes: Microbiological aspects, Drugs, 49, 76, 10.2165/00003495-199500492-00012
King, 2000, New classification and update on the quinolone antibiotics, Am Fam Physician, 61, 2741
Al-Ahmad, 1999, Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria, Arch Environ Contam Toxicol, 37, 158, 10.1007/s002449900501
Campagnolo, 2002, Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations, Sci Total Environ, 299, 89, 10.1016/S0048-9697(02)00233-4
Golet, 2002, Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley watershed, Switzerland, Environ Sci Technol, 36, 3645, 10.1021/es0256212
Kolpin, 2002, Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: A national reconnaissance, Environ Sci Technol, 36, 1202, 10.1021/es011055j
Calamari, 2003, Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern italy, Environ Sci Technol, 37, 1241, 10.1021/es020158e
Fairchild, 1998, Comparative sensitivity of five species of macrophytes and six species of algae to atrazine, metribuzin, alachlor, and metolachlor, Environ Toxicol Chem, 17, 1830, 10.1002/etc.5620170924
Halling-Sòrensen, 2000, Algal toxicity of antibacterial agents used in intensive farming, Chemosphere, 40, 731, 10.1016/S0045-6535(99)00445-2
Fogg, 1973, The Blue-Green Algae
Nelson, 1999, Chronic effects of atrazine on tolerance of a benthic diatom, Environ Toxicol Chem, 18, 1038, 10.1002/etc.5620180531
Taylor, 2001
Wang, 1990, Literature review on duckweed toxicity testing, Environ Res, 52, 7, 10.1016/S0013-9351(05)80147-1
U.S. Environmental Protection Agency., 1993, Methods for measuring the acute toxicity of effluents and receiving waters to freshwater and marine organisms, 4th ed.
Youngman, 1998, Environmental Toxicology and Risk Assessment, 227
U.S. Environmental Protection Agency., 1988, Protocols for short term toxicity screening of hazardous waste sites
Hartmann, 1999, Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital wastewaters, Arch Environ Contam Toxicol, 36, 115, 10.1007/s002449900449
U.S. Environmental Protection Agency., 1994, Short-term methods for estimating the chronic toxicity of effluents and receiving waters to freshwater organisms, 3rd ed.
Yorke, 2000, Quantitation of nine quinolones in chicken tissues by high-performance liquid chromatography with fluorescence detection, J Chromatogr A, 882, 63, 10.1016/S0021-9673(00)00165-5
SAS Institute., 2000
Schabenberger, 1999, Statistical tests for hormesis and effective dosages in herbicide dose response, Agron J, 91, 713, 10.2134/agronj1999.914713x
Halling-Sørensen, 2000, Environmental risk assessment of antibiotics: Comparison of mecillinam, trimethoprim, and ciprofloxacin, J Antimicrob Chemother, 46, 53, 10.1093/jac/46.suppl_1.53
Holten Lützhøft, 1999, Algal toxicity of antibacterial agents applied in Danish fish farming, Arch Environ Contam Toxicol, 36, 1, 10.1007/s002449900435
McFadden, 1999, Apicomplexan plastids as drug targets, Trends Microbiol, 7, 328, 10.1016/S0966-842X(99)01547-4
Brain, 2004, Effects of 25 pharmaceutical compounds to Lemna minor using a seven-day static renewal test, Environ Toxicol Chem, 23, 371, 10.1897/02-576
Zoccarato, 1995, Effect of dietary avoparcin on performances and carcass composition in rainbow trout, Oncorhynchus mykiss (Walbaum), Aquacult Res, 26, 361, 10.1111/j.1365-2109.1995.tb00924.x
Migliore, 2000, Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L, Chemosphere, 40, 741, 10.1016/S0045-6535(99)00448-8
Wollenberger, 2000, Acute and chronic toxicity of veterinary antibiotics to Daphnia magna, Chemosphere, 40, 723, 10.1016/S0045-6535(99)00443-9
Migliore, 1997, Toxicity of several important agricultural antibiotics to Artemia, Water Res, 31, 1801, 10.1016/S0043-1354(96)00412-5
Burhenne, 1997, Primary photoproducts and half-lives, Environ Sci Pollut Res, 4, 10, 10.1007/BF02986257
Nowara, 1997, Binding of fluoroquinolone carboxylic acid derivatives to clay minerals, J Agric Food Chem, 45, 1459, 10.1021/jf960215l
Simpson, 2003, Effect of declining toxicant concentrations on algal bioassay endpoints, Environ Toxicol Chem, 22, 2073, 10.1897/02-418
Hartmann, 1998, Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater, Environ Toxicol Chem, 17, 377, 10.1897/1551-5028(1998)017<0377:IOFAAT>2.3.CO;2
Golet, 2001, Trace determination of fluoroquinolone antibacterial agents in urban wastewater by solid-phase extraction and liquid chromatography with fluorescence detection, Anal Chem, 73, 3632, 10.1021/ac0015265