Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review
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Dankovic D, Kuempel E, Wheeler M (2007) An approach to risk assessment for TiO2. Inhal Toxicol 19(s1):205–212. doi: 10.1080/08958370701497754
Robertson TA, Sanchez WY, Roberts MS (2010) Are commercially available nanoparticles safe when applied to the skin? J Biomed Nanotechnol 6(5):452–468. doi: 10.1166/jbn.2010.1145
Weir A, Westerhoff P, Fabricius L, von Goetz N (2012) Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46(4):2242–2250. doi: 10.1021/es204168d
Zhao J, Castranova V (2011) Toxicology of nanomaterials used in nanomedicine. J Toxicol Environ Health, Part B 14(8):593–632. doi: 10.1080/10937404.2011.615113
Saber AT, Jacobsen NR, Mortensen A, Szarek J, Jackson P, Madsen AM, Jensen KA, Koponen IK, Brunborg G, Gützkow KB, Vogel U, Wallin H (2012) Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint. Part Fibre Toxicol 9:4–4. doi: 10.1186/1743-8977-9-4
Gao G, Ze Y, Zhao X, Sang X, Zheng L, Ze X, Gui S, Sheng L, Sun Q, Hong J, Yu X, Wang L, Zhang FH (2013) Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice. J Hazard Mater 258:133–143
Weir A, Westerhoff P, Fabricius L, Hristovski K, Goetz N (2012) Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46(4):2242–2250
Shi H, Magaye R, Castranova V, Zhao J (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:15–15. doi: 10.1186/1743-8977-10-15
Senzui M, Tamura T, Miura K, Ikarashi Y, Watanabe Y, Fujii M (2010) Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro. J Toxicol Sci 35(1):107–113. doi: 10.2131/jts.35.107
Newman MD, Stotland M, Ellis JI (2009) The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol 61(4):685–692. doi: 10.1016/j.jaad.2009.02.051
Sadrieh N, Wokovich AM, Gopee NV, Zheng J, Haines D, Parmiter D, Siitonen PH, Cozart CR, Patri AK, McNeil SE, Howard PC, Doub WH, Buhse LF (2010) Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles. Toxicol Sci 115(1):156–166. doi: 10.1093/toxsci/kfq041
Escobar-Chavez JJ, Merino-Sanjuan V, Lopez-Cervantes M, Urban-Morlan Z, Pinon-Segundo E, Quintanar-Guerrero D, Ganem-Quintanar A (2008) The tape-stripping technique as a method for drug quantification in skin. J Pharm Pharm Sci 11(1):104–30
Filipe P, Silva JN, Silva R, Cirne de Castro JL, Marques Gomes M, Alves LC, Santus R, Pinheiro T (2009) Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption. Skin Pharmacol Physiol 22(5):266–275
Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE (2011) Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci 123(1):264–280. doi: 10.1093/toxsci/kfr148
Bennat C, Müller-Goymann CC (2000) Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter. Int J Cosmet Sci 22(4):271–83. doi: 10.1046/j.1467-2494.2000.00009.x
Furukawa F, Doi Y, Suguro M, Morita O, Kuwahara H, Masunaga T, Hatakeyama Y, Mori F (2011) Lack of skin carcinogenicity of topically applied titanium dioxide nanoparticles in the mouse. Food Chem Toxicol 49(4):744–749. doi: 10.1016/j.fct.2010.11.036
Sagawa Y, Futakuchi M, Xu J, Fukamachi K, Sakai Y, Ikarashi Y, Nishimura T, Suzui M, Tsuda H, Morita A (2012) Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice. J Toxicol Sci 37(2):317–327. doi: 10.2131/jts.37.317
Xu J, Sagawa Y, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Ikarashi Y, Uchino T, Nishimura T, Morita A, Suzui M, Tsuda H (2011) Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats. Food Chem Toxicol 49(6):1298–1302. doi: 10.1016/j.fct.2011.03.011
Wu J, Liu W, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng F-D (2009) Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191(1):1–8. doi: 10.1016/j.toxlet.2009.05.020
Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM (2007) Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 171(3):99–110. doi: 10.1016/j.toxlet.2007.04.008
Liu Q, Hong Z, Guo B-g, Zhang Y, Li Y, Liu J (2006) Experimental study on toxicity of nanosized titanium dioxide. Mod Prev Med 33:1211–1212
Unnithan J, Rehman M, Ahmad F, Samim M (2011) Aqueous synthesis and concentration-dependent dermal toxicity of TiO2 nanoparticles in Wistar rats. Biol Trace Elem Res 143(3):1682–1694. doi: 10.1007/s12011-011-9010-4
Yanagisawa R, Takano H, K-i I, Koike E, Kamachi T, Sadakane K, Ichinose T (2009) Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice. Exp Biol Med 234(3):314–322. doi: 10.3181/0810-rm-304
Simkó M, Mattsson M-O (2010) Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical review. Part Fibre Toxicol 7:42–42. doi: 10.1186/1743-8977-7-42
Kuempel ED, Tran CL, Castranova V, Bailer AJ (2006) Lung dosimetry and risk assessment of nanoparticles: evaluating and extending current models in rats and humans. Inhal Toxicol 18(10):717–24. doi: 10.1080/08958370600747887
Mühlfeld C, Geiser M, Kapp N, Gehr P, Rothen-Rutishauser B (2007) Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the “relative deposition index”: evidence for clearance through microvasculature. Part Fibre Toxicol 4:7–7. doi: 10.1186/1743-8977-4-7
van Ravenzwaay B, Landsiedel R, Fabian E, Burkhardt S, Strauss V, Ma-Hock L (2009) Comparing fate and effects of three particles of different surface properties: nano-TiO2, pigmentary TiO2 and quartz. Toxicol Lett 186(3):152–159. doi: 10.1016/j.toxlet.2008.11.020
Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77(2):347–357. doi: 10.1093/toxsci/kfh019
Lindberg HK, Falck GCM, Catalán J, Koivisto AJ, Suhonen S, Järventaus H, Rossi EM, Nykäsenoja H, Peltonen Y, Moreno C, Alenius H, Tuomi T, Savolainen KM, Norppa H (2012) Genotoxicity of inhaled nanosized TiO2 in mice. Mutat Res Gen Toxicol Environ Mutagen 745(1–2):58–64. doi: 10.1016/j.mrgentox.2011.10.011
Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Chen BT, Frazer DG, Boegehold MA, Castranova V (2009) Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling. Toxicol Sci 110(1):191–203. doi: 10.1093/toxsci/kfp051
LeBlanc AJ, Cumpston JL, Chen BT, Frazer D, Castranova V, Nurkiewicz TR (2009) Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles. J Toxicol Environ Health Part A 72(24):1576–1584. doi: 10.1080/15287390903232467
Knuckles TL, Yi J, Frazer DG, Leonard HD, Chen BT, Castranova V, Nurkiewicz TR (2012) Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways. Nanotoxicol 6(7):724–735. doi: 10.3109/17435390.2011.606926
LeBlanc AJ, Moseley AM, Chen BT, Frazer D, Castranova V, Nurkiewicz TR (2010) Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism. Cardiovasc Toxicol 10(1):27–36. doi: 10.1007/s12012-009-9060-4
Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Moseley AM, Cumpston JL, Goodwill AG, Frisbee SJ, Perrotta PL, Brock RW, Frisbee JC, Boegehold MA, Frazer DG, Chen BT, Castranova V (2011) Pulmonary particulate matter and systemic microvascular dysfunction. Res Rep Health Eff Inst 164:3–48
Scuri M, Chen BT, Castranova V, Reynolds JS, Johnson VJ, Samsell L, Walton C, Piedimonte G (2010) Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways. J Toxicol Environ Health Part A 73(20):1353–1369. doi: 10.1080/15287394.2010.497436
Hougaard K, Jackson P, Jensen K, Sloth J, Loschner K, Larsen E, Birkedal R, Vibenholt A, Boisen A-M, Wallin H, Vogel U (2010) Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 7(1):16
Halappanavar S, Jackson P, Williams A, Jensen KA, Hougaard KS, Vogel U, Yauk CL, Wallin H (2011) Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study. Environ Mol Mutagen 52(6):425–439. doi: 10.1002/em.20639
Noël A, Charbonneau M, Cloutier Y, Tardif R, Truchon G (2013) Rat pulmonary responses to inhaled nano-TiO2: effect of primary particle size and agglomeration state. Part Fibre Toxicol 10(1):48
Ma-Hock L, Burkhardt S, Strauss V, Gamer AO, Wiench K, van Ravenzwaay B, Landsiedel R (2009) Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance. Inhal Toxicol 21(2):102–118. doi: 10.1080/08958370802361057
Grassian VH, O’Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS (2007) Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115(3):397–402. doi: 10.1289/ehp.9469
Sun Q, Hong X, Wold LE (2010) Cardiovascular effects of ambient particulate air pollution exposure. Circulation 121(25):2755–2765. doi: 10.1161/CIRCULATIONAHA.109.893461
Rossi EM, Pylkkänen L, Koivisto A, Nykasenoja H, Wolff H, Savolainen K, Alenius H (2010) Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model. Part Fibre Toxicol 7(1):35
Rossi EM, Pylkkänen L, Koivisto AJ, Vippola M, Jensen KA, Miettinen M, Sirola K, Nykäsenoja H, Karisola P, Stjernvall T, Vanhala E, Kiilunen M, Pasanen P, Mäkinen M, Hämeri K, Joutsensaari J, Tuomi T, Jokiniemi J, Wolff H, Savolainen K, Matikainen S, Alenius H (2010) Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice. Toxicol Sci 113(2):422–433. doi: 10.1093/toxsci/kfp254
Morimoto Y, Oyabu T, Ogami A, Myojo T, Kuroda E, Hirohashi M, Shimada M, Lenggoro W, Okuyama K, Tanaka I (2011) Investigation of gene expression of MMP-2 and TIMP-2 mRNA in rat lung in inhaled nickel oxide and titanium dioxide nanoparticles. Ind Health 49(3):344–352. doi: 10.2486/indhealth.MS1218
Leppänen M, Korpi A, Miettinen M, Leskinen J, Torvela T, Rossi E, Vanhala E, Wolff H, Alenius H, Kosma V-M, Joutsensaari J, Jokiniemi J, Pasanen P (2011) Nanosized TiO2 caused minor airflow limitation in the murine airways. Arch Toxicol 85(7):827–839. doi: 10.1007/s00204-011-0644-y
Eydner M, Schaudien D, Creutzenberg O, Ernst H, Hansen T, Baumgärtner W, Rittinghausen S (2012) Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes, translocation within the rat lung, and evaluation of particle deposition using the relative deposition index. Inhal Toxicol 24(9):557–569. doi: 10.3109/08958378.2012.697494
Lee KP, Trochimowicz HJ, Reinhardt CF (1985) Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicol Appl Pharmacol 79(2):179–192. doi: 10.1016/0041-008X(85)90339-4
Baskerville A, Fitzgeorge RB, Gilmour MI, Dowsett AB, Williams A, Featherstone AS (1988) Effects of inhaled titanium dioxide dust on the lung and on the course of experimental Legionnaires’ disease. Br J Exp Pathol 69(6):781–792
Warheit DB, Yuen IS, Kelly DP, Snajdr S, Hartsky MA (1996) Subchronic inhalation of high concentrations of low toxicity, low solubility particulates produces sustained pulmonary inflammation and cellular proliferation. Toxicol Lett 88(1–3):249–53
Warheit DB, Hansen JF, Yuen IS, Kelly DP, Snajdr SI, Hartsky MA (1997) Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation. Toxicol Appl Pharmacol 145(1):10–22. doi: 10.1006/taap.1997.8102
Bermudez E, Mangum JB, Asgharian B, Wong BA, Reverdy EE, Janszen DB, Hext PM, Warheit DB, Everitt JI (2002) Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol Sci 70(1):86–97. doi: 10.1093/toxsci/70.1.86
Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB (2000) Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55(1):24–35. doi: 10.1093/toxsci/55.1.24
Sager TM, Kommineni C, Castranova V (2008) Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol 5:17–17. doi: 10.1186/1743-8977-5-17
Li Y, Li J, Yin J, Li W, Kang C, Huang Q, Li Q (2010) Systematic influence induced by 3 nm titanium dioxide following intratracheal instillation of mice. J Nanosci Nanotechnol 10(12):8544–9
Park E-J, Yoon J, Choi K, Yi J, Park K (2009) Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicol 260(1–3):37–46. doi: 10.1016/j.tox.2009.03.005
Kobayashi N, Naya M, Endoh S, Maru J, Yamamoto K, Nakanishi J (2009) Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: different short- and long-term post-instillation results. Toxicol 264(1–2):110–118. doi: 10.1016/j.tox.2009.08.002
Liu R, Yin L, Pu Y, Liang G, Zhang J, Su Y, Xiao Z, Ye B (2009) Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats. Prog Nat Sci 19(5):573–579. doi: 10.1016/j.pnsc.2008.06.020
Sager T, Castranova V (2009) Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6(1):15
Tang M, Zhang T, Xue Y, Wang S, Huang M, Yang Y, Lu M, Lei H, Kong L, Yuepu P (2010) Dose dependent in vivo metabolic characteristics of titanium dioxide nanoparticles. J Nanosci Nanotechnol 10(12):8575–8583
Roursgaard M, Jensen KA, Poulsen SS, Jensen NE, Poulsen LK, Hammer M, Nielsen GD, Larsen ST (2011) Acute and subchronic airway inflammation after intratracheal instillation of quartz and titanium dioxide agglomerates in mice. Sci World J 11:801–825. doi: 10.1100/tsw.2011.67
Nemmar A, Melghit K, Al-Salam S, Zia S, Dhanasekaran S, Attoub S, Al-Amri I, Ali BH (2011) Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO2 nanorods. Toxicol 279(1–3):167–175. doi: 10.1016/j.tox.2010.10.007
Sun Q, Tan D, Ze Y, Sang X, Liu X, Gui S, Cheng Z, Cheng J, Hu R, Gao G, Liu G, Zhu M, Zhao X, Sheng L, Wang L, Tang M, Hong F (2012) Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice. J Hazard Mater 235–236:47–53. doi: 10.1016/j.jhazmat.2012.05.072
Sun Q, Tan D, Zhou Q, Liu X, Cheng Z, Liu G, Zhu M, Sang X, Gui S, Cheng J, Hu R, Tang M, Hong F (2012) Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles. J Biomed Mater Res Part A 100A(10):2554–2562. doi: 10.1002/jbm.a.34190
Husain M, Saber AT, Guo C, Jacobsen NR, Jensen KA, Yauk CL, Williams A, Vogel U, Wallin H, Halappanavar S (2013) Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation. Toxicol Appl Pharmacol 269(3):250–262. doi: 10.1016/j.taap.2013.03.018
Liang G, Pu Y, Yin L, Liu R, Ye B, Su Y, Li Y (2009) Influence of different sizes of titanium dioxide nanoparticles on hepatic and renal functions in rats with correlation to oxidative stress. J Toxicol Environ Health Part A 72(11–12):740–745. doi: 10.1080/15287390902841516
Tang M, Zhang T, Xue Y, Wang S, Huang M, Yang Y, Lu M, Lei H, Kong L, Wang Y, Pu Y (2011) Metabonomic studies of biochemical changes in the serum of rats by intratracheally instilled TiO2 nanoparticles. J Nanosci Nanotechnol 11(4):3065–3074. doi: 10.1166/jnn.2011.3604
Gustafsson Å, Lindstedt E, Elfsmark LS, Bucht A (2011) Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat. J Immunotoxicol 8(2):111–121. doi: 10.3109/1547691X.2010.546382
Liu R, Zhang X, Pu Y, Yin L, Li Y, Zhang X, Liang G, Li X, Zhang J (2010) Small-sized titanium dioxide nanoparticles mediate immune toxicity in rat pulmonary alveolar macrophages in vivo. J Nanosci Nanotechnol 10(8):5161–5169. doi: 10.1166/jnn.2010.2420
Fu Y, Zhang Y, Chang X, Zhang Y, Ma S, Sui J, Yin L, Pu Y, Liang G (2014) Systemic immune effects of titanium dioxide nanoparticles after repeated intratracheal instillation in rat. Int J Mol Sci 15(4):6961–6973. doi: 10.3390/ijms15046961
Naya M, Kobayashi N, Ema M, Kasamoto S, Fukumuro M, Takami S, Nakajima M, Hayashi M, Nakanishi J (2012) In vivo genotoxicity study of titanium dioxide nanoparticles using comet assay following intratracheal instillation in rats. Regul Toxicol Pharmacol 62(1):1–6. doi: 10.1016/j.yrtph.2011.12.002
Cho W-S, Duffin R, Poland CA, Howie SEM, MacNee W, Bradley M, Megson IL, Donaldson K (2010) Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118(12):1699–1706. doi: 10.1289/ehp.1002201
Zhang G, Shinohara N, Kano H, Senoh H, Suzuki M, Sasaki T, Fukushima S, Gamo M (2015) Quantitative evaluation of the pulmonary microdistribution of TiO2 nanoparticles using X-ray fluorescence microscopy after intratracheal administration with a microsprayer in rats. J Appl Toxicol 35(6):623–630. doi: 10.1002/jat.3109
Courtois A, Andujar P, Ladeiro Y, Ducret T, Rogerieux F, Lacroix G, Baudrimont I, Guibert C, Roux E, Canal-Raffin M, Brochard P, Marano F, Marthan R, Muller B (2010) Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery. Toxicol Appl Pharmacol 245(2):203–210. doi: 10.1016/j.taap.2010.03.002
Liu R, Yin LH, Pu YP, Li YH, Zhang XQ, Liang GY, Li XB, Zhang J, Li YF, Zhang XY (2010) The immune toxicity of titanium dioxide on primary pulmonary alveolar macrophages relies on their surface area and crystal structure. J Nanosci Nanotechnol 10(12):8491–9
Hussain S, Vanoirbeek JAJ, Luyts K, De Vooght V, Verbeken E, Thomassen LCJ, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PHM (2011) Lung exposure to nanoparticles modulates an asthmatic response in a mouse model. Eur Respir J 37(2):299–309. doi: 10.1183/09031936.00168509
Zhang Y, Tao J, He P, Tang Y, Wang Y (2009) Bio-effects of nano-TiO2 on lungs of mice. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26(4):803–6
Oberdorster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC (2000) Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst (96):5–74; disc. 75–86.
Hu JQ, Chen CY, Bai R, Zhen S, Du XM, Zang JJ, Li JC, Gu YQ, Jia G (2010) Effect of nano-TiO(2) intratracheal instillation on lipid metabolism of AopE gene-knockout mice. Zhonghua Yu Fang Yi Xue Za Zhi 44(9):780–4
Warheit DB, Webb TR, Sayes CM, Colvin VL, Reed KL (2006) Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci 91(1):227–236. doi: 10.1093/toxsci/kfj140
Yu X, Zhao X, Ze Y, Wang L, Liu D, Hong J, Xu B, Lin A, Zhang C, Zhao Y, Li B, Hong F (2014) Changes of serum parameters of TiO2 nanoparticle-induced atherosclerosis in mice. J Hazard Mater 280:364–371. doi: 10.1016/j.jhazmat.2014.08.015
Wang J, Chen C, Liu Y, Jiao F, Li W, Lao F, Li Y, Li B, Ge C, Zhou G, Gao Y, Zhao Y, Chai Z (2008) Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183(1–3):72–80. doi: 10.1016/j.toxlet.2008.10.001
Wang J, Liu Y, Jiao F, Lao F, Li W, Gu Y, Li Y, Ge C, Zhou G, Li B, Zhao Y, Chai Z, Chen C (2008) Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicol 254(1–2):82–90. doi: 10.1016/j.tox.2008.09.014
Chen J, Dong X, Xin Y, Zhao M (2011) Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure. Aquat Toxicol 101(3–4):493–499. doi: 10.1016/j.aquatox.2010.12.004
Ze Y, Zheng L, Zhao X, Gui S, Sang X, Su J, Guan N, Zhu L, Sheng L, Hu R, Cheng J, Cheng Z, Sun Q, Wang L, Hong F (2013) Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice. Chemosphere 92(9):1183–1189. doi: 10.1016/j.chemosphere.2013.01.094
Ze Y, Hu R, Wang X, Sang X, Ze X, Li B, Su J, Wang Y, Guan N, Zhao X, Gui S, Zhu L, Cheng Z, Cheng J, Sheng L, Sun Q, Wang L, Hong F (2014) Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. J Biomed Mater Res Part A 102(2):470–478. doi: 10.1002/jbm.a.34705
Wang JX, Li YF, Zhou GQ, Li B, Jiao F, Chen CY, Gao YX, Zhao YL, Chai ZF (2007) Influence of intranasal instilled titanium dioxide nanoparticles on monoaminergic neurotransmitters of female mice at different exposure time. Zhonghua Yu Fang Yi Xue Za Zhi Chin J Prevent Med 41(2):91–95
Hagens WI, Oomen AG, de Jong WH, Cassee FR, Sips AJAM (2007) What do we (need to) know about the kinetic properties of nanoparticles in the body? Reg Toxicol Pharmacol 49(3):217–229. doi: 10.1016/j.yrtph.2007.07.006
Lomer MCE, Thompson RPH, Powell JJ (2002) Fine and ultrafine particles of the diet: influence on the mucosal immune response and association with Crohn’s disease. Proc Nutr Soc 61(01):123–130. doi: 10.1079/PNS2001134
Hillyer JF, Albrecht RM (2001) Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90(12):1927–1936. doi: 10.1002/jps.1143
El-Sharkawy NI, Hamza SM, Abou-Zeid EH (2010) Toxic impact of titanium dioxide (TiO2) in male albino rats with special reference to its effect on reproductive system. J Am Sci 6(11):865–872
Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, Jia G, Gao Y, Li B, Sun J, Li Y, Jiao F, Zhao Y, Chai Z (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168(2):176–185. doi: 10.1016/j.toxlet.2006.12.001
Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, Cao Z, Zhou T, Xue A, Wang Y, Cen X, Zhao YL (2010) NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnol 21(12):125105. doi: 10.1088/0957-4484/21/12/125105
Shrivastava R, Raza S, Yadav A, Kushwaha P, Flora SJS (2014) Effects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brain. Drug Chem Toxicol 37(3):336–347. doi: 10.3109/01480545.2013.866134
Fadda LM, Abdel Baky N, Al-Rasheed NM, Al-Rasheed NM, Bassiouni YA (2013) Ameliorative effect of quercetin and idebenone against oxidative stress, inflammation, DNA damage and apoptosis induced in rat livers after oral exposure to titanium dioxide nanoparticles. J Clin Toxicol 3:5. doi: 10.4172/2161-0495.S1.008
Vasantharaja D, Ramalingam V, Aadinaath Reddy G (2015) Oral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats. Nanomedicine J 2(1):46–53
Elbastawisy YM, Saied HA (2013) Effects of exposure to titanium dioxide nanoparticles on albino rat visual cortex “electron microscopic study”. J Am Sci 9(5):432–439
Faddah LM, Abdel Baky NA, Al-Rasheed NM, Al-Rasheed NM (2013) Biochemical responses of nanosize titanium dioxide in the heart of rats following administration of idepenone and quercetin. Afr J Pharm Pharmacol 7(38):2639–2651. doi: 10.5897/AJPP2013.3426
Mohammadipour A, Hosseini M, Fazel A, Haghir H, Rafatpanah H, Pourganji M, Ebrahimzadeh Bideskan A (2013) The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring. Toxicol Ind Health. doi: 10.1177/0748233713498440
Ze Y, Sheng L, Zhao X, Hong J, Ze X, Yu X, Pan X, Lin A, Zhao Y, Zhang C, Zhou Q, Wang L, Hong F (2014) TiO2 nanoparticles induced hippocampal neuroinflammation in mice. PLoS ONE 9(3), e92230. doi: 10.1371/journal.pone.0092230
Geraets L, Oomen A, Krystek P, Jacobsen N, Wallin H, Laurentie M, Verharen H, Brandon E, de Jong W (2014) Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol 11(1):30
Chalew TEA, Ajmani GS, Huang H, Schwab KJ (2013) Evaluating nanoparticle breakthrough during drinking water treatment. Environ Health Perspect 121(10):1161–1166. doi: 10.1289/ehp.1306574
Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH (2009) Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 69(22):8784–8789. doi: 10.1158/0008-5472.can-09-2496
Swart AM, Burdett S, Ledermann J, Mook P, Parmar MK (2008) Why i.p. therapy cannot yet be considered as a standard of care for the first-line treatment of ovarian cancer: a systematic review. Ann Oncol 19(4):688–95. doi: 10.1093/annonc/mdm518
Bihari P, Holzer M, Praetner M, Fent J, Lerchenberger M, Reichel CA, Rehberg M, Lakatos S, Krombach F (2010) Single-walled carbon nanotubes activate platelets and accelerate thrombus formation in the microcirculation. Toxicol 269(2–3):148–154. doi: 10.1016/j.tox.2009.08.011
Younes NRB, Amara S, Mrad I, Ben-Slama I, Jeljeli M, Omri K, El Ghoul J, El Mir L, Rhouma K, Abdelmelek H, Sakly M (2015) Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination. Environ Sci Pollut Res 22(11):8728–8737. doi: 10.1007/s11356-014-4002-5
Chen J, Dong X, Zhao J, Tang G (2009) In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitoneal injection. J Appl Toxicol 29(4):330–337. doi: 10.1002/jat.1414
Guo LL, Liu XH, Qin DX, Gao L, Zhang HM, Liu JY, Cui YG (2009) Effects of nanosized titanium dioxide on the reproductive system of male mice. Zhonghua Nan Ke Xue 15(6):517–22
Li N, Duan Y, Hong M, Zheng L, Fei M, Zhao X, Wang J, Cui Y, Liu H, Cai J, Gong S, Wang H, Hong F (2010) Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticles. Toxicol Lett 195(2–3):161–168. doi: 10.1016/j.toxlet.2010.03.1116
Moon E-Y, Yi G-H, Kang J-S, Lim J-S, Kim H-M, Pyo S (2011) An increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticles. J Immunotoxicol 8(1):56–67. doi: 10.3109/1547691X.2010.543995
Moon C, Park H-J, Choi Y-H, Park E-M, Castranova V, Kang JL (2010) Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide. J Toxicol Environ Health Part A 73(5–6):396–409. doi: 10.1080/15287390903486543
Shin JA, Lee EJ, Seo SM, Kim HS, Kang JL, Park EM (2010) Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse. Neuroscience 165(2):445–454. doi: 10.1016/j.neuroscience.2009.10.057
Alarifi S, Ali D, Al-Doaiss AA, Ali BA, Ahmed M, Al-Khedhairy AA (2013) Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats. Int J Nanomedicine 8:3937–43. doi: 10.2147/ijn.s47174
Jeon Y-M, Kim W-J, Lee M-Y (2013) Studies on liver damage induced by nanosized-titanium dioxide in mouse. J Environ Biol 34(2):283–287
Liu H, Ma L, Zhao J, Liu J, Yan J, Ruan J, Hong F (2009) Biochemical toxicity of nano-anatase TiO2 particles in mice. Biol Trace Elem Res 129(1–3):170–180. doi: 10.1007/s12011-008-8285-6
Ma L, Zhao J, Wang J, Liu J, Duan Y, Liu H, Li N, Yan J, Ruan J, Wang H, Hong F (2009) The acute liver injury in mice caused by nano-anatase TiO(2). Nanoscale Res Lett 4(11):1275–1285. doi: 10.1007/s11671-009-9393-8
Ma L, Liu J, Li N, Wang J, Duan Y, Yan J, Liu H, Wang H, Hong F (2010) Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials 31(1):99–105. doi: 10.1016/j.biomaterials.2009.09.028
Larsen ST, Roursgaard M, Jensen KA, Nielsen GD (2010) Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice. Basic Clin Pharmacol Toxicol 106(2):114–117. doi: 10.1111/j.1742-7843.2009.00473.x
Takeda K, K-i S, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, Oshio S, Nihei Y, Ihara T, Sugamata M (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55(1):95–102. doi: 10.1248/jhs.55.95
Umezawa M, Tainaka H, Kawashima N, Shimizu M, Takeda K (2012) Effect of fetal exposure to titanium dioxide nanoparticle on brain development—brain region information. J Toxicol Sci 37(6):1247–1252. doi: 10.2131/jts.37.1247
Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K (2009) Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol 6(1):20
Takahashi Y, Mizuo K, Shinkai Y, Oshio S, Takeda K (2010) Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice. J Toxicol Sci 35(5):749–756. doi: 10.2131/jts.35.749
Hansen T, Clermont G, Alves A, Eloy R, Brochhausen C, Boutrand JP, Gatti AM, Kirkpatrick CJ (2006) Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles. J R Soc Interface 3(11):767–775. doi: 10.1098/rsif.2006.0145
Gatti A, Kirkpatrick J, Gambarelli A, Capitani F, Hansen T, Eloy R, Clermont G (2008) ESEM evaluations of muscle/nanoparticles interface in a rat model. J Mater Sci Mater Med 19(4):1515–1522. doi: 10.1007/s10856-008-3385-6
Onuma K, Sato Y, Ogawara S, Shirasawa N, Kobayashi M, Yoshitake J, Yoshimura T, Iigo M, Fujii J, Okada F (2009) Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells. Am J Pathol 175(5):2171–2183. doi: 10.2353/ajpath.2009.080900
Xu J, Shi H, Ruth M, Yu H, Lazar L, Zou B, Yang C, Wu A, Zhao J (2013) Acute toxicity of intravenously administered titanium dioxide nanoparticles in mice. PLoS ONE 8(8), e70618. doi: 10.1371/journal.pone.0070618
Scown TM, van Aerle R, Johnston BD, Cumberland S, Lead JR, Owen R, Tyler CR (2009) High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function. Toxicol Sci 109(2):372–380. doi: 10.1093/toxsci/kfp064
Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T, Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, S-i T, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y (2011) Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nano 6(5):321–328. doi: 10.1038/nnano.2011.41
González-Esquivel AE, Charles-Niño CL, Pacheco-Moisés FP, Ortiz GG, Jaramillo-Juárez F, Rincón-Sánchez AR (2015) Beneficial effects of quercetin on oxidative stress in liver and kidney induced by titanium dioxide (TiO2) nanoparticles in rats. Toxicol Mech Methods 25(3):166–175. doi: 10.3109/15376516.2015.1006491
Wang J-X, Fan Y-B, Gao Y, Hu Q-H, Wang T-C (2009) TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection. Biomaterials 30(27):4590–4600. doi: 10.1016/j.biomaterials.2009.05.008
Wang J, Gao Y, Hou Y, Zhao F, Pu F, Liu X, Wu Z, Fan Y (2012) Evaluation on cartilage morphology after intra-articular injection of titanium dioxide nanoparticles in rats. J Nanomat 2012:11. doi: 10.1155/2012/452767
Cui Y, Chen X, Zhou Z, Lei Y, Ma M, Cao R, Sun T, Xu J, Huo M, Cao R, Wen C, Che Y (2014) Prenatal exposure to nanoparticulate titanium dioxide enhances depressive-like behaviors in adult rats. Chemosphere 96:99–104. doi: 10.1016/j.chemosphere.2013.07.051
Cui Y, Gong X, Duan Y, Li N, Hu R, Liu H, Hong M, Zhou M, Wang L, Wang H, Hong F (2010) Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. J Hazard Mater 183(1–3):874–880. doi: 10.1016/j.jhazmat.2010.07.109
Cui Y, Liu H, Zhou M, Duan Y, Li N, Gong X, Hu R, Hong M, Hong F (2011) Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. J Biomed Mater Res Part A 96A(1):221–229. doi: 10.1002/jbm.a.32976
Hu R, Zheng L, Zhang T, Gao G, Cui Y, Cheng Z, Cheng J, Hong M, Tang M, Hong F (2011) Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J Hazard Mater 191(1–3):32–40. doi: 10.1016/j.jhazmat.2011.04.027
Wang J, Li N, Zheng L, Wang S, Wang Y, Zhao X, Duan Y, Cui Y, Zhou M, Cai J, Gong S, Wang H, Hong F (2011) P38-Nrf-2 signaling pathway of oxidative stress in mice caused by nanoparticulate TiO2. Biol Trace Elem Res 140(2):186–197. doi: 10.1007/s12011-010-8687-0
Gui S, Sang X, Zheng L, Ze Y, Zhao X, Sheng L, Sun Q, Cheng Z, Cheng J, Hu R, Wang L, Hong F, Tang M (2013) Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications. Part Fibre Toxicol 10(1):4
Duan Y, Liu J, Ma L, Li N, Liu H, Wang J, Zheng L, Liu C, Wang X, Zhao X, Yan J, Wang S, Wang H, Zhang X, Hong F (2010) Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials 31(5):894–899. doi: 10.1016/j.biomaterials.2009.10.003
Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, Zhou M, Liu C, Wang H, Hong F (2010) Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 31(31):8043–8050. doi: 10.1016/j.biomaterials.2010.07.011
Sang X, Zheng L, Sun Q, Li N, Cui Y, Hu R, Gao G, Cheng Z, Cheng J, Gui S, Liu H, Zhang Z, Hong F (2012) The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles. J Biomed Mater Res Part A 100A(4):894–902. doi: 10.1002/jbm.a.34024
Zhao X, Ze Y, Gao G, Sang X, Li B, Gui S, Sheng L, Sun Q, Cheng J, Cheng Z, Hu R, Wang L, Hong F (2013) Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS ONE 8(4), e59378. doi: 10.1371/journal.pone.0059378
Zhao J, Li N, Wang S, Zhao X, Wang J, Yan J, Ruan J, Wang H, Hong F (2010) The mechanism of oxidative damage in the nephrotoxicity of mice caused by nano-anatase TiO2. J Exp Nanosci 5(5):447–462. doi: 10.1080/17458081003628931
Mohamed HRH (2014) Attenuation of nano-TiO2 induced genotoxicity, mutagenicity and apoptosis by chlorophyllin in mice cardiac cells. Int J Sci Res 3(6):2625–2636
Jeon Y-M, Park S-K, Lee M-Y (2011) Toxicoproteomic identification of TiO2 nanoparticle-induced protein expression changes in mouse brain. Anim Cells Syst 15(2):107–114. doi: 10.1080/19768354.2011.555144
Li N, Ma L, Wang J, Zheng L, Liu J, Duan Y, Liu H, Zhao X, Wang S, Wang H, Hong F, Xie Y (2010) Interaction between nano-anatase TiO2 and liver DNA from mice in vivo. Nanoscale Res Lett 5(1):108–115. doi: 10.1007/s11671-009-9451-2
Li S-Q, Zhu R-R, Zhu H, Xue M, Sun X-Y, Yao S-D, Wang S-L (2008) Nanotoxicity of TiO2 nanoparticles to erythrocyte in vitro. Food Chem Toxicol 46(12):3626–3631. doi: 10.1016/j.fct.2008.09.012
Aisaka Y, Kawaguchi R, Watanabe S, Ikeda M, Igisu H (2008) Hemolysis caused by titanium dioxide particles. Inhal Toxicol 20(9):891–893. doi: 10.1080/08958370802304123
Zhang J, Song W, Guo J, Zhang J, Sun Z, Li L, Ding F, Gao M (2013) Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages. Toxicol Ind Health 29(6):523–533. doi: 10.1177/0748233712442708
Qi K, Deng FR, Guo XB (2009) Effects of nanoscale titanium dioxide on intercellular gap junction communication in human lung fibroblasts. Beijing Da Xue Xue Bao 41(3):297–301
Adachi K, Yamada N, Yamamoto K, Yoshida Y, Yamamoto O (2010) In vivo effect of industrial titanium dioxide nanoparticles experimentally exposed to hairless rat skin. Nanotoxicol 4(3):296–306. doi: 10.3109/17435391003793095
Miquel-Jeanjean C, Crépel F, Raufast V, Payre B, Datas L, Bessou-Touya S, Duplan H (2012) Penetration study of formulated nanosized titanium dioxide in models of damaged and sun-irradiated skins. Photochem Photobiol 88(6):1513–1521. doi: 10.1111/j.1751-1097.2012.01181.x
Braydich-Stolle LK, Schaeublin NM, Murdock RC, Jiang J, Biswas P, Schlager J, Hussain SM (2009) Crystal structure mediates mode of cell death in TiO2 nanotoxicity. J Nanoparticle Res 11(6):1361–1374. doi: 10.1007/s11051-008-9523-8
Savi M, Rossi S, Bocchi L, Gennaccaro L, Cacciani F, Perotti A, Amidani D, Alinovi R, Goldoni M, Aliatis I, Lottici PP, Bersani D, Campanini M, Pinelli S, Petyx M, Frati C, Gervasi A, Urbanek K, Quaini F, Buschini A, Stilli D, Rivetti C, Macchi E, Mutti A, Miragoli M, Zaniboni M (2014) Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue. Part Fibre Toxicol 11(1):63. doi: 10.1186/s12989-014-0063-3
Wang Y, Wu Q, Sui K, Chen X-X, Fang J, Hu X, Wu M, Liu Y (2013) A quantitative study of exocytosis of titanium dioxide nanoparticles from neural stem cells. Nanoscale 5(11):4737–4743. doi: 10.1039/C3NR00796K