Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives

Bipolar Disorders - Tập 14 Số 8 - Trang 888-893 - 2012
Sarah K. Tighe1, Sarah Reading1,2,3, Paul Rivkin1, Brian Caffo4, Barbara Schweizer1, Godfrey D. Pearlson5,6, James B. Potash7, J. Raymond DePaulo1, Susan Spear Bassett1
1Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD
2Department of Psychiatry and Neuroscience, University of South Florida, Tampa, FL
3Mental Health and Behavioral Science Service, The James A. Haley Veterans' Hospital, Tampa, FL
4Department of Biostatistics, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD
5Departments of Psychiatry and Neurobiology, Yale University, New Haven, CT
6Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT
7Department of Psychiatry, The University of Iowa, Iowa City, IA, USA

Tóm tắt

Tighe SK, Reading SA, Rivkin P, Caffo B, Schweizer B, Pearlson G, Potash JB, DePaulo J Raymond, Bassett SS. 
Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives. 
Bipolar Disord 2012: 14: 888–893. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd.Objectives: White matter hyperintensities (WMH) are more common in subjects with bipolar disorder (BP) than in healthy subjects (HS). Few studies have examined the effect of the diagnostic type of bipolar illness on WMH burden, and none have approached this question through a direct measurement of the volume of affected white matter in relationship to familiality. In this pilot study, we utilized a volumetric measurement of WMH to investigate the relationship between the total volume of WMH and the familiality and type of BP.Methods: Forty‐five individuals with bipolar I disorder (BP‐I) with psychotic features, BP‐I without psychotic features, or bipolar II disorder (BP‐II), seven of their unaffected relatives, and 32 HS were recruited for participation. T‐2 weighted magnetic resonance imaging scans were obtained on all subjects, and the total volume of all WMH for each subject was measured in cubic centimeters. The significance of difference between groups was tested using ANOVA with post‐hoc adjustment for multiple comparisons. Further, we used logistic regression to test for trends between symptom load and total WMH volume.Results: The mean total volume of WMH in BP‐I patients with psychotic features was significantly higher (p < 0.05) than that of HS. Further, we observed a positive linear trend by familiality and type of affectedness when comparing mean total WMH volume of HS, unaffected family members, subjects with BP‐II, and BP‐I with and without a history of psychosis (p < 0.05).Conclusions: Based on a quantitative technique, WMH burden appears to be associated with familiality and type of BP. The significance of these findings remains to be fully elucidated.

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Bipolar Disorders

Tập 14 Số 8

888-893

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