Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation

Courtneidge SA, Heber A: An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase. Cell. 1987, 50: 1031-1037.

Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD: Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2001, 17: 615-675. 10.1146/annurev.cellbio.17.1.615.

Cantrell DA: Phosphoinositide 3-kinase signalling pathways. J Cell Sci. 2001, 114: 1439-1445.

Vanhaesebroeck B, Waterfield MD: Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 1999, 253: 239-254. 10.1006/excr.1999.4701.

Domin J, Waterfield MD: Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett. 1997, 410: 91-95. 10.1016/S0014-5793(97)00617-0.

Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD: P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A. 1997, 94: 4330-4335. 10.1073/pnas.94.9.4330.

Bernstein HG, Keilhoff G, Reiser M, Freese S, Wetzker R: Tissue distribution and subcellular localization of a G-protein activated phosphoinositide 3-kinase. An immunohistochemical study. Cell Mol Biol (Noisy-le-grand). 1998, 44: 973-983.

Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD: Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 2001, 70: 535-602. 10.1146/annurev.biochem.70.1.535.

Wheeler M, Domin J: Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. Mol Cell Biol. 2001, 21: 6660-6667. 10.1128/MCB.21.19.6660-6667.2001.

Domin J, Gaidarov I, Smith ME, Keen JH, Waterfield MD: The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles. J Biol Chem. 2000, 275: 11943-11950. 10.1074/jbc.275.16.11943.

Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol Cell Biol. 2000, 20: 3817-3830. 10.1128/MCB.20.11.3817-3830.2000.

Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR: Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. J Biol Chem. 1999, 274: 14529-14532. 10.1074/jbc.274.21.14529.

Turner SJ, Domin J, Waterfield MD, Ward SG, Westwick J: The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem. 1998, 273: 25987-25995. 10.1074/jbc.273.40.25987.

Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD: Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem. 1998, 273: 33082-33090. 10.1074/jbc.273.49.33082.

Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD: Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J. 1997, 326: 139-147.

Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics. 1998, 54: 569-574. 10.1006/geno.1998.5621.

Ho LK, Liu D, Rozycka M, Brown RA, Fry MJ: Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily. Biochem Biophys Res Commun. 1997, 235: 130-137. 10.1006/bbrc.1997.6747.

Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. Embo J. 1995, 14: 3339-3348.

Stein RC, Waterfield MD: PI3-kinase inhibition: a target for drug development?. Mol Med Today. 2000, 6: 347-357. 10.1016/S1357-4310(00)01770-6.

Lin X, Bohle AS, Dohrmann P, Leuschner I, Schulz A, Kremer B, Fandrich F: Overexpression of phosphatidylinositol 3-kinase in human lung cancer. Langenbecks Arch Surg. 2001, 386: 293-301. 10.1007/s004230100203.

Inukai K, Funaki M, Ogihara T, Katagiri H, Kanda A, Anai M, Fukushima Y, Hosaka T, Suzuki M, Shin BC, Takata K, Yazaki Y, Kikuchi M, Oka Y, Asano T: p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem. 1997, 272: 7873-7882. 10.1074/jbc.272.12.7873.

Leblond CP: Classification of cell populations on the basis of their proliferative behaviour. NCI Monogr. 1963, 14: 19-145.

Preston SL, Alison MR, Forbes SJ, Direkze NC, Poulsom R, Wright NA: The new stem cell biology: something for everyone. Mol Pathol. 2003, 56: 86-96. 10.1136/mp.56.2.86.

Zhu L, Skoultchi AI: Coordinating cell proliferation and differentiation. Curr Opin Genet Dev. 2001, 11: 91-97. 10.1016/S0959-437X(00)00162-3.

Brittan M, Wright NA: Gastrointestinal stem cells. J Pathol. 2002, 197: 492-509. 10.1002/path.1155.

Niemann C, Watt FM: Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol. 2002, 12: 185-192. 10.1016/S0962-8924(02)02263-8.

Cooke HJ: Immortalizing the immortal. Nat Genet. 2002, 32: 90-91. 10.1038/ng0902-90.

Klippel A, Escobedo MA, Wachowicz MS, Apell G, Brown TW, Giedlin MA, Kavanaugh WM, Williams LT: Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol. 1998, 18: 5699-5711.

Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, Rivas C, Burgering BM, Serrano M, Lam EW: Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem. 2000, 275: 21960-21968. 10.1074/jbc.M000759200.

Tresini M, Mawal-Dewan M, Cristofalo VJ, Sell C: A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. Cancer Res. 1998, 58: 1-4.

Chakravarthy Manu V., Abraha Tsghe W., Schwartz Robert J., Fiorotto Marta L., Booth Frank W.: Insulin-like Growth Factor-I Extends in Vitro Replicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3'-Kinase/Akt Signaling Pathway. J. Biol. Chem. 2000, 275: 35942-35952. 10.1074/jbc.M005832200.

Hallmann Daniel, Trumper Katja, Trusheim Heidi, Ueki Kohjiro, Kahn C. Ronald, Cantley Lewis C., Fruman David A., Horsch Dieter: Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85alpha . J. Biol. Chem. 2003, 278: 5099-5108. 10.1074/jbc.M208451200.

Laprise P, Chailler P, Houde M, Beaulieu JF, Boucher MJ, Rivard N: Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation. J Biol Chem. 2002, 277: 8226-8234. 10.1074/jbc.M110235200.

Wang Q, Wang X, Hernandez A, Kim S, Evers BM: Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. Gastroenterology. 2001, 120: 1381-1392.

Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM: PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology. 2002, 123: 1163-1178. 10.1053/gast.2002.36043.

Kissel Holger, Timokhina Inna, Hardy Matthew P., Rothschild Gerson, Tajima Youichi, Soares Vera, Angeles Michael, Whitlow Scott R., Manova Katia, Besmer Peter: Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses. EMBO J. 2000, 19: 1312-1326. 10.1093/emboj/19.6.1312.

Neri LM, Borgatti P, Capitani S, Martelli AM: The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta. 2002, 1584: 73-10.1016/S1388-1981(02)00300-1.

Visnjic D, Crljen V, Curic J, Batinic D, Volinia S, Banfic H: The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells. FEBS Lett. 2002, 529: 268-274. 10.1016/S0014-5793(02)03357-4.

Sindic A, Aleksandrova A, Fields AP, Volinia S, Banfic H: Presence and activation of nuclear phosphoinositide 3-kinase C2beta during compensatory liver growth. J Biol Chem. 2001, 276: 17754-17761. 10.1074/jbc.M006533200.

Gillooly David J., Simonsen Anne, Stenmark Harald: Phosphoinositides and phagocytosis. J. Cell Biol. 2001, 155: 15-18. 10.1083/jcb.200109001.

Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S: Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol. 2001, 155: 19-25. 10.1083/jcb.200107069.

Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC: Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999, 283: 393-397. 10.1126/science.283.5400.393.

Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S: Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science. 1999, 283: 390-392. 10.1126/science.283.5400.390.

Yu Jinghua, Zhang Yitao, McIlroy James, Rordorf-Nikolic Tamara, Orr George A., Backer Jonathan M.: Regulation of the p85/p110 Phosphatidylinositol 3'-Kinase: Stabilization and Inhibition of the p110alpha Catalytic Subunit by the p85 Regulatory Subunit. Mol. Cell. Biol. 1998, 18: 1379-1387.

Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 2002, 22: 965-977.

Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Kadowaki T, et al.: Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet. 1999, 21: 230-235. 10.1038/6023.

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR: Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest. 2002, 109: 141-149. 10.1172/JCI200213305.

Woenckhaus J, Steger K, Werner E, Fenic I, Gamerdinger U, Dreyer T, Stahl U: Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma. J Pathol. 2002, 198: 335-342. 10.1002/path.1207.

Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez AC, Avila J, Carrera AC: Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol. 2000, 151: 249-262. 10.1083/jcb.151.2.249.

Okkenhaug K, Vanhaesebroeck B: New responsibilities for the PI3K regulatory subunit p85 alpha. Sci STKE. 2001, 2001: PE1-

Niswender Kevin D., Gallis Byron, Blevins James E., Corson Marshall A., Schwartz Michael W., Baskin Denis G.: Immunocytochemical Detection of Phosphatidylinositol 3-kinase Activation by Insulin and Leptin. J. Histochem. Cytochem. 2003, 51: 275-283.