Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high‐fat diet‐induced obese mice

Obesity - Tập 21 Số 1 - Trang 115-122 - 2013
Gong‐Rak Lee1, Mi‐Kyung Shin2, Dong‐Joon Yoon3, Ah‐Ram Kim3, Rina Yu4, Neung Hwa Park3,5,6,7, In‐Seob Han3,6,7
1Department of Medical Science, School of Medicine, University of Ulsan, Ulsan, Korea
2Department of Pathology, Hallym University Medical Center, Seoul, Korea
3Department of Biological Sciences, University of Ulsan, Ulsan, Korea
4Department of Food Science and Nutrition, University of Ulsan, Ulsan, Korea
5Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Korea
6In-Seob Han, Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Korea
7Neung-Hwa Park, Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Korea

Tóm tắt

AbstractObjective:Visceral obesity contributes to the development of obesity‐related disorders such as diabetes, hyperlipidemia, and fatty liver disease, as well as cardiovascular diseases. In this study, we determined whether topical application of capsaicin can reduce fat accumulation in visceral adipose tissues.Methods and Results:We first observed that topical application of 0.075% capsaicin to male mice fed a high‐fat diet significantly reduced weight gain and visceral fat. Fat cells were markedly smaller in the mesenteric and epididymal adipose tissues of mice treated with capsaicin cream. The capsaicin treatment also lowered serum levels of fasting glucose, total cholesterol, and triglycerides. Immunoblot analysis and RT‐PCR revealed increased expression of adiponectin and other adipokines including peroxisome proliferator‐activated receptor (PPAR) α, PPARγ, visfatin, and adipsin, but reduced expression of tumor necrosis factor‐α and IL‐6.Conclusions:These results indicate that topical application of capsaicin to obese mice limits fat accumulation in adipose tissues and may reduce inflammation and increase insulin sensitivity.

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Thông tin
Thông tin xuất bản

Obesity

Tập 21 Số 1

115-122

Thông tin tác giả