Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

Genes and Immunity - Tập 5 Số 5 - Trang 343-346 - 2004
Kelan G. Tantisira1, Walter T. Klimecki2, Ross Lazarus1,3, Lyle J. Palmer4, Benjamin A. Raby1, David J. Kwiatkowski5,6, Edwin K. Silverman1, Donata Vercelli2, Fernando D. Martínez2, Scott T. Weiss1,5
1Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
2Arizona Respiratory Center, University of Arizona, Tucson, USA
3Department of Public Health and Community Medicine, University of Sydney, Australia
4Western Australian Institute for Medical Research, Center for Medical Research, University of Western Australia, Perth, Australia
5Harvard Partners Center for Genetics and Genomics, USA
6Hematology Division, Brigham and Women’s Hospital, Boston, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Kadowaki N, Ho S, Antonenko S et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001: 863–869.

Means TK, Golenbock DT, Fenton MJ . The biology of Toll-like receptors. Cytokine Growth Factor Rev 2000; 11: 219–232.

Hallman M, Ramet M, Ezekowitz RA . Toll-like receptors as sensors of pathogens. Pediatr Res 2001; 50: 315–321.

Takeuchi O, Kawai T, Sanjo H et al. TLR6: a novel member of an expanding toll-like receptor family. Gene 1999; 231: 59–65.

Guo SW, Thompson EA . Performing the exact test of Hardy–Weinberg proportion for multiple alleles. Biometrics 1992; 48: 361–372.

Cargill M, Altshuler D, Ireland J et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 1999; 22: 231–238.

Halushka MK, Fan JB, Bentley K et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet 1999; 22: 239–247.

Goddard KA, Hopkins PJ, Hall JM, Witte JS . Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet 2000; 66: 216–234.

Stampfer MJ, Willett WC, Colditz GA et al. A prospective study of postmenopausal estrogen therapy and coronary heart disease. N Engl J Med 1985; 313: 1044–1049.

Bell B, Rose CL, Damon H . The Normative Aging Study: an interdisciplinary and longitudinal study of health and aging. Aging Hum Dev 1972; 3: 5–17.

Manson JE, Grobbee DE, Stampfer MJ et al. Aspirin in the primary prevention of angina pectoris in a randomized trial of United States physicians. Am J Med 1990; 89: 772–776.

Strachan DP . Hay fever, hygiene, and household size. BMJ 1989; 299: 1259–1260.

Romagnani S . Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 1992; 98: 279–285.

Bach JF . Protective role of infections and vaccinations on autoimmune diseases. J Autoimmun 2001; 16: 347–353.

Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM . Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 2001; 108: 1865–1873.

Arbour NC, Lorenz E, Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187–191.

Von Ehrenstein OS, Von Mutius E, Illi S et al. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000; 30: 187–193.

Hume DA, Underhill DM, Sweet MJ et al. Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunol 2001; 2: 11.

McCurdy JD, Olynych TJ, Maher LH, Marshall JS . Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J Immunol 2003; 170: 1625–1629.

Bradding P . The role of the mast cell in asthma: a reassessment. Curr Opin Allergy Clin Immunol 2003; 3: 45–50.

Busse WW, Lemanske Jr. RF . Asthma. N Engl J Med 2001; 344: 350–362.