Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells

Pereira, 2000, A clonal subpopulation of Leptospira interrogans sensu stricto is the major cause of leptospirosis outbreaks in Brazil, J Clin Microbiol, 38, 450, 10.1128/JCM.38.1.450-452.2000 Farr, 1995, Leptospirosis, Clin Infect Dis, 21, 1, 10.1093/clinids/21.1.1 Sitprija, 1980, Pathogenesis of renal disease in leptospirosis: clinical and experimental studies, Kidney Int, 17, 827, 10.1038/ki.1980.95 Yang, 2001, Leptospirosis renal disease, Nephrol Dial Transplant, 16, 73, 10.1093/ndt/16.suppl_5.73 Vinh, 1986, Ultrastructure and chemical composition of lipopolysaccharide extracted from Leptospira interrogans serovar copenhageni, J Gen Microbiol, 132, 103 Yang, 2000, Leptospira outer membrane protein activates NF-kappaB and downstream genes expressed in medullary thick ascending limb cells, J Am Soc Nephrol, 11, 2017, 10.1681/ASN.V11112017 Yang, 2002, The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells, J Am Soc Nephrol, 13, 2037, 10.1097/01.ASN.0000022007.91733.62 Barnett, 1999, Expression and distribution of leptospiral outer membrane components during renal infection of hamsters, Infect Immun, 67, 853, 10.1128/IAI.67.2.853-861.1999 Medzhitov, 1997, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, 388, 394, 10.1038/41131 Takeda, 2003, Toll-like receptors, Annu Rev Immunol, 21, 335, 10.1146/annurev.immunol.21.120601.141126 Tsuboi, 2002, Roles of toll-like receptors in C–C chemokine production by renal tubular epithelial cells, J Immunol, 169, 2026, 10.4049/jimmunol.169.4.2026 Wolfs, 2002, In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation, J Immunol, 168, 1286, 10.4049/jimmunol.168.3.1286 Chow, 1999, Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction, J Biol Chem, 274, 10689, 10.1074/jbc.274.16.10689 Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3 Yoshimura, 1999, Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2, J Immunol, 163, 1, 10.4049/jimmunol.163.1.1 Lien, 1999, Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products, J Biol Chem, 274, 33419, 10.1074/jbc.274.47.33419 Re, 2001, Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells, J Biol Chem, 276, 37692, 10.1074/jbc.M105927200 Werts, 2001, Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism, Nat Immunol, 2, 346, 10.1038/86354 Cartier, 1993, Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene, J Cell Sci, 104, 695, 10.1242/jcs.104.3.695 Cario, 2002, Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium, Am J Pathol, 160, 165, 10.1016/S0002-9440(10)64360-X Hornef, 2002, Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells, J Exp Med, 195, 559, 10.1084/jem.20011788 Akira, 2004, Toll-like receptor signalling, Nat Rev Immunol, 4, 499, 10.1038/nri1391 Zhang, 2004, A toll-like receptor that prevents infection by uropathogenic bacteria, Science, 303, 1522, 10.1126/science.1094351 Anders, 2004, Signaling danger: Toll-like receptors and their potential roles in kidney disease, J Am Soc Nephrol, 15, 854, 10.1097/01.ASN.0000121781.89599.16 Medzhitov, 2001, Toll-like receptors and innate immunity, Nat Rev Immunol, 1, 135, 10.1038/35100529 Yang, 1998, Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling, Nature, 395, 284, 10.1038/26239 Kirschning, 2002, TLR2: cellular sensor for microbial and endogenous molecular patterns, Curr Top Microbiol Immunol, 270, 121 Hagberg, 1984, Difference in susceptibility to Gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice, Infect Immun, 46, 839, 10.1128/iai.46.3.839-844.1984 Haake, 2000, The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection, Infect Immun, 68, 2276, 10.1128/IAI.68.4.2276-2285.2000 Nunes-Edwards, 1985, Identification and characterization of the protein antigens of Leptospira interrogans serovar hardjo, Infect Immun, 48, 492, 10.1128/iai.48.2.492-497.1985 Zuerner, 1991, Characterization of outer membrane and secreted proteins of Leptospira interrogans serovar pomona, Microb Pathog, 10, 311, 10.1016/0882-4010(91)90014-2 Brown, 1991, Protein and antigen profiles of prevalent serovars of Leptospira interrogans, Infect Immun, 59, 1772, 10.1128/iai.59.5.1772-1777.1991 Vinh, 1986, Glycolipoprotein cytotoxin from Leptospira interrogans serovar copenhageni, J Gen Microbiol, 132, 111 Tang, 1997, Chemokine expression in experimental tubulointerstitial nephritis, J Immunol, 159, 870, 10.4049/jimmunol.159.2.870 Lloyd, 1997, Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis, J Leukocyte Biol, 62, 676, 10.1002/jlb.62.5.676 Vasselon, 2002, Toll-like receptor 2 (TLR2) mediates activation of stress-activated MAP kinase p38, J Leukocyte Biol, 71, 503, 10.1189/jlb.71.3.503 Koizumi, 2003, Identification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera, J Med Microbiol, 52, 585, 10.1099/jmm.0.05148-0 Yang, 1997, Differential expression of glomerular extracellular matrix and growth factor mRNA in rapid and slowly progressive glomerulosclerosis: studies in mice transgenic for native or mutated growth hormone, Lab Invest, 76, 467 Yang, 1998, Aminoguanidine reduces glomerular inducible nitric oxide synthase (iNOS) and transforming growth factor-beta 1 (TGF-beta1) mRNA expression and diminishes glomerulosclerosis in NZB/WF1 mice, Clin Exp Immunol, 113, 258, 10.1046/j.1365-2249.1998.00632.x Yang, 1994, Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease, Proc Natl Acad Sci USA, 91, 9436, 10.1073/pnas.91.20.9436 Yang, 1995, Overexpression of transforming growth factor-beta 1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice, J Am Soc Nephrol, 5, 1610, 10.1681/ASN.V581610