Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection

The American Journal of Pathology - Tập 164 - Trang 49-57 - 2004
Michael B. Drennan1, Delphine Nicolle2, Valerie J.F. Quesniaux2, Muazzam Jacobs1, Nasiema Allie1, Joseph Mpagi1, Cécile Frémond2, Hermann Wagner3, Carsten Kirschning3, Bernhard Ryffel2
1Department of Immunology, University of Cape Town, Cape Town, South Africa
2Centre National de la Recherche Scientifique (CNRS), GEM2358, Orleans, France
3Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany

Tài liệu tham khảo

Flynn, 2001, Immunology of tuberculosis, Annu Rev Immunol, 19, 93, 10.1146/annurev.immunol.19.1.93 Luster, 2002, The role of chemokines in linking innate and adaptive immunity, Curr Opin Immunol, 14, 129, 10.1016/S0952-7915(01)00308-9 Takeda, 2003, Toll-like receptors, Annu Rev Immunol, 21, 335, 10.1146/annurev.immunol.21.120601.141126 Underhill, 1999, Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages, Proc Natl Acad Sci USA, 96, 14459, 10.1073/pnas.96.25.14459 Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3 Brightbill, 1999, Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors, Science, 285, 732, 10.1126/science.285.5428.732 Jones, 2001, Different Toll-like receptor agonists induce distinct macrophage responses, J Leukoc Biol, 69, 1036, 10.1189/jlb.69.6.1036 Means, 1999, Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis, J Immunol, 163, 3920, 10.4049/jimmunol.163.7.3920 Thoma-Uszynski, 2001, Induction of direct antimicrobial activity through mammalian toll-like receptors, Science, 291, 1544, 10.1126/science.291.5508.1544 Thoma-Uszynski, 2000, Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10, J Immunol, 165, 3804, 10.4049/jimmunol.165.7.3804 Hertz, 2001, Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2, J Immunol, 166, 2444, 10.4049/jimmunol.166.4.2444 Noss, 2001, Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis, J Immunol, 167, 910, 10.4049/jimmunol.167.2.910 Abel, 2002, Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice, J Immunol, 169, 3155, 10.4049/jimmunol.169.6.3155 Reiling, 2002, Cutting edge: toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis, J Immunol, 169, 3480, 10.4049/jimmunol.169.7.3480 Michelsen, 2001, The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2, J Biol Chem, 276, 25680, 10.1074/jbc.M011615200 Marino, 1997, Characterization of tumor necrosis factor-deficient mice, Proc Natl Acad Sci USA, 94, 8093, 10.1073/pnas.94.15.8093 Jacobs, 2000, Correction of defective host response to Mycobacterium bovis BCG infection in TNF-deficient mice by bone marrow transplantation, Lab Invest, 80, 901, 10.1038/labinvest.3780094 Garcia, 2000, Lethal Mycobacterium bovis Bacillus Calmette Guerin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2, Lab Invest, 80, 1385, 10.1038/labinvest.3780146 Sallusto, 1999, Mobilizing dendritic cells for tolerance, priming and chronic inflammation, J Exp Med, 189, 611, 10.1084/jem.189.4.611 Holscher, 1998, Defective nitric-oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in γ-interferon receptor or inducible nitric-oxide synthase, Infect Immun, 66, 1208, 10.1128/IAI.66.3.1208-1215.1998 Kirman, 1999, CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection, Infect Immun, 67, 3786, 10.1128/IAI.67.8.3786-3792.1999 Sousa, 1997, In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas, J Exp Med, 186, 1819, 10.1084/jem.186.11.1819 Flynn, 1995, Tumor necrosis factor-α is required in the protective immune response against M. tuberculosis in mice, Immunity, 2, 561, 10.1016/1074-7613(95)90001-2 Liu, 2001, Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity, Cell, 106, 259, 10.1016/S0092-8674(01)00456-1 Stenger, 2002, Control of Mycobacterium tuberculosis through mammalian Toll-like receptors, Curr Opin Immunol, 14, 452, 10.1016/S0952-7915(02)00355-2 Means, 2001, Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses, J Immunol, 166, 4074, 10.4049/jimmunol.166.6.4074 Kamath, 2003, Toll-like receptor 4-defective C3H/HeJ mice are not more susceptible than other C3H substrains to infection with Mycobacterium tuberculosis, Infect Immun, 71, 4112, 10.1128/IAI.71.7.4112-4118.2003 Bulut, 2001, J Immunol, 167, 987, 10.4049/jimmunol.167.2.987 Takeuchi, 2002, Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins, J Immunol, 169, 10, 10.4049/jimmunol.169.1.10 Massari, 2002, Cutting edge: immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent, J Immunol, 168, 1533, 10.4049/jimmunol.168.4.1533 Adachi, 2001, Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism, J Immunol, 167, 5928, 10.4049/jimmunol.167.10.5928 Takeuchi, 2000, Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection, J Immunol, 165, 5392, 10.4049/jimmunol.165.10.5392 Wooten, 2002, Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi, J Immunol, 168, 348, 10.4049/jimmunol.168.1.348 Wolfs, 2002, In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation, J Immunol, 168, 1286, 10.4049/jimmunol.168.3.1286 Schnare, 2001, Toll-like receptors control activation of adaptive immune responses, Nat Immunol, 2, 947, 10.1038/ni712 Flesch, 1994, Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10, Int Immunol, 6, 693, 10.1093/intimm/6.5.693 Flesch, 1990, Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor, Infect Immun, 58, 2675, 10.1128/IAI.58.8.2675-2677.1990 Chan, 1992, Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages, J Exp Med, 175, 1111, 10.1084/jem.175.4.1111 Roach, 2002, TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection, J Immunol, 168, 4620, 10.4049/jimmunol.168.9.4620 Jacobs, 2000, Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice, Clin Immunol, 94, 192, 10.1006/clim.2000.4835 Bean, 1999, Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin, J Immunol, 162, 3504, 10.4049/jimmunol.162.6.3504 Moreira, 1997, Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis, Tuber Lung Dis, 78, 47, 10.1016/S0962-8479(97)90015-0 Rook, 1987, The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis, Immunology, 62, 229 Moreira, 2002, Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice, Infect Immun, 70, 2100, 10.1128/IAI.70.4.2100-2107.2002 Engele, 2002, Induction of TNF in human alveolar macrophages as a potential evasion mechanism of virulent Mycobacterium tuberculosis, J Immunol, 168, 1328, 10.4049/jimmunol.168.3.1328 Schjetne, 2003, Link between innate and adaptive immunity: toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target, J Immunol, 171, 32, 10.4049/jimmunol.171.1.32