Tissue-specific metabolite profiling and quantitative analysis of ginsenosides in Panax quinquefolium using laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry

Yujie Chen1, Liang Xu2, Yuancen Zhao1, Zhongzhen Zhao1, Hubiao Chen1, Tao Yi1, Minjian Qin3, Zhitao Liang1
1School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, People’s Republic of China
2School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China
3Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Modern Chinese Medicines, College of Traditional Chinese Medicines, China Pharmaceutical University, Tongjiaxiang-24, Gulou District, Nanjing, 210009, People’s Republic of China

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Tài liệu tham khảo

Cai X, Zhang AX, Wu H, Hu ZH (1999) Histochemistry of sinomenine in the stem of Sinomenium acutum and Sinomenium acutum var. cinereum. Acta BotBoreali-Occidentalia Sin 19:104–107

Shen ZG, Chauser-volfson E, Gutterman Y, Hu ZH (2001) Anatomy, histochemistry and phytochemistry of leaves in Aloe vera var. chinensis. Acta Bot Sin 43:780–787

Lin R, Cao YF, Hu ZH (2002) Anatomical structure of vegetative organs and histochemical localization of ginsenosides in Gynostemma pentaphyllum. Acta Bot Boreali-Occidentalia Sin 22:796–800

Cao YF, Lin R, Hu ZH (2003) Studies on the developmental anatomy of Rhizome of Dioscorea zingiberensis and its histochemistry. J Wuhan Bot Res 21:288–294

Qiao Q, Xiao YP, Wang ZZ (2004) Anatomical structure and histochemical localization of the drupe of Macrocarpium officinacle. Acta Bot Yunnanica 26:651–655

Liang ZT, Sham TT, Yang GY, Yi L, Chen HB, Zhao ZZ (2013) Profiling of secondary metabolites in tissues from Rheum palmatum L. using laser microdissection and liquid chromatography mass spectrometry. Anal Bioanal Chem 405:4199–4212

Liang ZT, Oh KY, Wang YQ, Yi T, Chen HB, Zhao ZZ (2014) Cell type-specific qualitative and quantitative analysis of saikosaponins in three Bupleurum species using laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry. J Pharm Biomed Anal 97:157–165

Liang ZT, Chen YJ, Xu L, Qin MJ, Yi T, Chen HB, Zhao ZZ (2015) Localization of ginsenosides in the rhizome and root of Panax ginseng by laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry. J Pharm Biomed Anal. 105c:121–133

Yi L, Liang ZT, Peng Y, Yao X, Chen HB, Zhao ZZ (2012) Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry. J Chromatogr A 1248:93–103

Chen YJ, Liang ZT, Zhu Y, Xie GY, Tian M, Zhao ZZ, Qin MJ (2014) Tissue-specific metabolites profiling and quantitative analyses of flavonoids in the rhizome of Belamcanda chinensis by combining laser-microdissection with UHPLC-Q/TOF-MS and UHPLC-QqQ-MS. Talanta 130:585–597

Jaiswal Y, Liang ZT, Ho A, Wong LL, Yong P, Chen HB, Zhao ZZ (2014) Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC–QTOF MS and LC–MS/MS techniques. Phytochemistry 107:155–174

Sun BS, Xu MY, Li Z, Wang YB, Sang CK (2012) UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming. J Ginseng Res 36:277–290

Attele AS, Wu JA, Yuan CS (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58:1685–1693

Dou DQ, Hou WB, Chen YJ (1998) Studies on the characteristic constituents of Chinese ginseng and American ginseng. Planta Med 64:585–586

Qi LW, Wang CZ, Yuan CS (2011) Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 72:689–699

Yuan CS, Wang CZ, Wicks SM, Qi LW (2010) Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res 34:160–167

Corbit RM, Ferreira JFS, Ebbs SD, Murphy LL (2005) Simplified extraction of ginsenosides from American ginseng (Panax quinquefolius L.) for high-performance liquid chromatography-ultraviolet analysis. J Agric Food Chem 53:9867–9873

Wang A, Wang CZ, Wu JA, Osinski J (2005) Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal 16:272–277

Qu CL, Bai YP, Jin XQ, Wang YT, Zhang K, You JY, Zhang HQ (2009) Study on ginsenosides in different parts and ages of Panax quinquefolius L. Food Chem 115:340–346

Zheng CN, Hao HP, Wang X, Wang XL, Wang GJ, Sang GW, Liang Y, Xie L, Xia CH, Yao XL (2009) Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI-IT-TOF/MS: Shengmai injection as an example. J Mass Spectrom 44:230–244

Qi LW, Wang CZ, Yuan CS (2011) Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep 28:467–495

Li SL, Shen H, Zhu LY, Xu J, Jia XB, Zhang HM, Lin G, Cai H, Cai BC, Chen SL, Xu HX (2012) Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng. J Chromatogr A 1231:31–45

Zhang HM, Li SL, Zhang H, Wang Y, Zhao ZL, Chen SL, Xu HX (2012) Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J Pharm Biomed Anal 62:258–273

Du XW, Wills RBH, Stuart DL (2004) Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chem 86:155–159

Liu WC, Zhang MP, Li CS, Sun CY, Jiang SC, Li C, Wang Y (2012) Determination of ginsenosides for different parts in Panax quinquefolium L. by HPLC. Chin J Ginseng Res. 22:20–23

Qu YX, Wang ZZ (2006) A study on saponins for different parts in Panax quinquefolium L. Chin J Prog in Modern Biomed 6:32–35