Tissue expression of alternatively spliced GFRα1, NCAM and RET isoforms and the distinct functional consequence of ligand-induced activation of GFRα1 isoforms

Airaksinen, 2002, The GDNF family: signalling, biological functions and therapeutic value, Nat. Rev. Neurosci., 3, 383, 10.1038/nrn812 Airaksinen, 1999, GDNF family neurotrophic factor signaling: four masters, one servant?, Mol. Cell. Neurosci., 13, 313, 10.1006/mcne.1999.0754 Baloh, 1997, TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret, Neuron, 18, 793, 10.1016/S0896-6273(00)80318-9 Baloh, 2000, The GDNF family ligands and receptors—Implications for neural development, Curr. Opin. Neurobiol., 10, 103, 10.1016/S0959-4388(99)00048-3 Borrello, 2002, Differential interaction of Enigma protein with the two RET isoforms, Biochem. Biophys. Res. Commun., 296, 515, 10.1016/S0006-291X(02)00886-0 Buj-Bello, 1997, Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase, Nature, 387, 721, 10.1038/42729 Buttner, 2004, Cytoplasmic domain of NCAM 180 reduces NCAM-mediated neurite outgrowth, J. Neurosci. Res., 75, 854, 10.1002/jnr.20049 Charlet-Berguerand, 2004, Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development, Cell Signalling, 16, 1425, 10.1016/j.cellsig.2004.05.006 Degl'Innocenti, 2004, Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching, Oncogene, 23, 7297, 10.1038/sj.onc.1207862 de Graaff, 2001, Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis, Genes Dev., 15, 2433, 10.1101/gad.205001 Dey, 1998, Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor, NeuroReport, 9, 37, 10.1097/00001756-199801050-00008 Dolatshad, 2002, Identification of GFR alpha-2 isoforms in myenteric plexus of postnatal and adult rat intestine, Brain Res. Mol. Brain Res., 107, 32, 10.1016/S0169-328X(02)00446-1 Eketjall, 1999, Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1–c-Ret receptor complex, EMBO J., 18, 5901, 10.1093/emboj/18.21.5901 Enomoto, 2004, GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration, Neuron, 44, 623, 10.1016/j.neuron.2004.10.032 Golden, 1999, Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse, Exp. Neurol., 158, 504, 10.1006/exnr.1999.7127 Jing, 1996, GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF, Cell, 85, 1113, 10.1016/S0092-8674(00)81311-2 Jing, 1997, GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family, J. Biol. Chem., 272, 33111, 10.1074/jbc.272.52.33111 Johnson, 2003, Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays, Science, 302, 2141, 10.1126/science.1090100 Klein, 1997, A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor, Nature, 387, 717, 10.1038/42722 Lee, 2002, RET receptor tyrosine kinase isoforms in kidney function and disease, Oncogene, 21, 5582, 10.1038/sj.onc.1205741 Leppanen, 2004, The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation, EMBO J., 23, 1452, 10.1038/sj.emboj.7600174 Lindahl, 2000, Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development, Mol. Cell. Neurosci., 15, 522, 10.1006/mcne.2000.0845 Lindahl, 2001, Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells, J. Biol. Chem., 276, 9344, 10.1074/jbc.M008279200 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method, Methods, 25, 402, 10.1006/meth.2001.1262 Lorenzo, 1997, RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2, Oncogene, 14, 763, 10.1038/sj.onc.1200894 Masure, 2000, Mammalian GFRalpha-4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin, J. Biol. Chem., 275, 39427, 10.1074/jbc.M003867200 Mikaels-Edman, 2003, Soluble and bound forms of GFRalpha1 elicit different GDNF-independent neurite growth responses in primary sensory neurons, Dev. Dyn., 227, 27, 10.1002/dvdy.10280 Modrek, 2002, A genomic view of alternative splicing, Nat. Genet., 30, 13, 10.1038/ng0102-13 Naveilhan, 1998, Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor, Proc. Natl. Acad. Sci. U. S. A., 95, 1295, 10.1073/pnas.95.3.1295 Pachnis, 1993, Expression of the c-ret proto-oncogene during mouse embryogenesis, Development, 119, 1005, 10.1242/dev.119.4.1005 Pachnis, 1998, Role Of the RET signal transduction pathway in development of the mammalian enteric nervous system, Am. J. Physiol., 275, G183 Paratcha, 2001, Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts, Neuron, 29, 171, 10.1016/S0896-6273(01)00188-X Paratcha, 2003, The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands, Cell, 113, 867, 10.1016/S0092-8674(03)00435-5 Pezeshki, 2001, Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret, J. Neurosci. Res., 66, 390, 10.1002/jnr.1231 Povlsen, 2003, Intracellular signaling by the neural cell adhesion molecule, Neurochem. Res., 28, 127, 10.1023/A:1021660531484 Saffell, 1995, NCAM requires a cytoplasmic domain to function as a neurite outgrowth-promoting neuronal receptor, Mol. Cell. Neurosci., 6, 521, 10.1006/mcne.1995.0004 Sanicola, 1997, Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins, Proc. Natl. Acad. Sci. U. S. A., 94, 6238, 10.1073/pnas.94.12.6238 Sariola, 2003, Novel functions and signalling pathways for GDNF, J. Cell Sci., 116, 3855, 10.1242/jcs.00786 Schedl, 2000, Cross-talk in kidney development, Curr. Opin. Genet. Dev., 10, 543, 10.1016/S0959-437X(00)00125-8 Shefelbine, 1998, Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux, Hum. Genet., 102, 474, 10.1007/s004390050724 Tahira, 1990, Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line, Oncogene, 5, 97 Takahashi, 2001, The GDNF/RET signaling pathway and human diseases, Cytokine Growth Factor Rev., 12, 361, 10.1016/S1359-6101(01)00012-0 Taraviras, 1999, Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system, Development, 126, 2785, 10.1242/dev.126.12.2785 Thompson, 1998, GFRalpha-4, a new GDNF family receptor, Mol. Cell. Neurosci., 11, 117, 10.1006/mcne.1998.0682 Too, 2003, Real time PCR quantification of GFRalpha-2 alternatively spliced isoforms in murine brain and peripheral tissues, Brain Res. Mol. Brain Res., 114, 146, 10.1016/S0169-328X(03)00169-4 Too, 1995, Simultaneous extraction of total RNA and peptides from tissues: application to tachykinins, Peptides, 16, 45, 10.1016/0196-9781(94)00151-U Treanor, 1996, Characterization of a multicomponent receptor for GDNF, Nature, 382, 80, 10.1038/382080a0 Trupp, 1997, Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS, J. Neurosci., 17, 3554, 10.1523/JNEUROSCI.17-10-03554.1997 Tsui-Pierchala, 2002, The long and short isoforms of Ret function as independent signaling complexes, J. Biol. Chem., 277, 34618, 10.1074/jbc.M203580200 Tsuzuki, 1995, Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues, Oncogene, 10, 191 Wang, 2000, Broad specificity of GDNF family receptors GFRalpha1 and GFRalpha2 for GDNF and NTN in neurons and transfected cells, J. Neurosci. Res., 61, 1, 10.1002/1097-4547(20000701)61:1<1::AID-JNR1>3.0.CO;2-J Wong, 1998, Identification of mammalian GFRalpha-2 splice isoforms, NeuroReport, 9, 3767, 10.1097/00001756-199812010-00002 Wong, 2002, Quantification of mouse glial cell-line derived neurotrophic factor family receptor alpha 2 alternatively spliced isoforms by real time detection PCR using SYBR Green I, Neurosci. Lett., 320, 141, 10.1016/S0304-3940(01)02282-0 Worby, 1998, Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family, J. Biol. Chem., 273, 3502, 10.1074/jbc.273.6.3502 Yu, 1998, Expression of GDNF family receptor components during development: implications in the mechanisms of interaction, J. Neurosci., 18, 4684, 10.1523/JNEUROSCI.18-12-04684.1998