Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

Immunity - Tập 38 Số 4 - Trang 792-804 - 2013
Daigo Hashimoto1,2, Andrew Chow1,2,3, Clara Noizat1,4, Pearline Teo5, Mary Beth Beasley6,7, Marylène Leboeuf1,2, Christian Becker1,7,2, Peter See5, Jeremy Price1,2, Daniel Lucas3, Melanie Greter1,8, Arthur Mortha1,2, Scott W. Boyer9, Camilla Forsberg10,9, Masato Tanaka11, Nico van Rooijen12, Adolfo García‐Sastre13,14,15, E. Richard Stanley16, Florent Ginhoux5, Paul S. Frenette3, Miriam Mérad1,2
1Department of Oncological Sciences and Tisch Cancer Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
2Immunology Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
3Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
4Université Pierre et Marie Curie, Paris 75005, France
5Singapore Immunology Network, Agency for Science, Technology and Research (A∗STAR), Immunos Building #3–4, Biopolis 138648, Singapore
6Department of Pathology, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
7Department of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
8Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland
9Program in Molecular, Cell, and Developmental Biology, Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
10Department of Biomolecular Engineering, Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
11Laboratory of Immune Regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachiouji, Tokyo 192-0392, Japan
12Department of Molecular Cell Biology, Vrije Universiteit, 1081 Amsterdam, The Netherlands
13Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
14Department of Microbiology, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
15Global Health and Emerging Pathogens Institute, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
16Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ajami, 2007, Local self-renewal can sustain CNS microglia maintenance and function throughout adult life, Nat. Neurosci., 10, 1538, 10.1038/nn2014

Asano, 2011, CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens, Immunity, 34, 85, 10.1016/j.immuni.2010.12.011

Bhowmick, 2004, TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, 303, 848, 10.1126/science.1090922

Bigley, 2011, The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency, J. Exp. Med., 208, 227, 10.1084/jem.20101459

Boring, 1997, Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice, J. Clin. Invest., 100, 2552, 10.1172/JCI119798

Boyer, 2011, All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells, Cell Stem Cell, 9, 64, 10.1016/j.stem.2011.04.021

Chawla, 2011, Macrophage-mediated inflammation in metabolic disease, Nat. Rev. Immunol., 11, 738, 10.1038/nri3071

Chow, 2011, Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche, J. Exp. Med., 208, 261, 10.1084/jem.20101688

Daems, 1982, Do resident macrophages proliferate?, Immunobiology, 161, 204, 10.1016/S0171-2985(82)80075-2

Emile, 2000, Langerhans cell deficiency in reticular dysgenesis, Blood, 96, 58

Ginhoux, 2009, The origin and development of nonlymphoid tissue CD103+ DCs, J. Exp. Med., 206, 3115, 10.1084/jem.20091756

Ginhoux, 2010, Fate mapping analysis reveals that adult microglia derive from primitive macrophages, Science, 330, 841, 10.1126/science.1194637

Goldszmid, 2012, NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection, Immunity, 36, 1047, 10.1016/j.immuni.2012.03.026

Hambleton, 2011, IRF8 mutations and human dendritic-cell immunodeficiency, N. Engl. J. Med., 365, 127, 10.1056/NEJMoa1100066

Haniffa, 2009, Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation, J. Exp. Med., 206, 371, 10.1084/jem.20081633

Hashimoto, 2011, Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome, Semin. Immunol., 23, 50, 10.1016/j.smim.2011.01.005

Helft, 2012, Cross-presenting CD103+ dendritic cells are protected from influenza virus infection, J. Clin. Invest., 122, 4037, 10.1172/JCI60659

Ingersoll, 2011, Monocyte trafficking in acute and chronic inflammation, Trends Immunol., 32, 470, 10.1016/j.it.2011.05.001

Jakubzick, 2008, Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations, J. Immunol., 180, 3019, 10.4049/jimmunol.180.5.3019

Jenkins, 2011, Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation, Science, 332, 1284, 10.1126/science.1204351

Kühn, 1995, Inducible gene targeting in mice, Science, 269, 1427, 10.1126/science.7660125

Kuziel, 1997, Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2, Proc. Natl. Acad. Sci. USA, 94, 12053, 10.1073/pnas.94.22.12053

Landsman, 2007, Distinct differentiation potential of blood monocyte subsets in the lung, J. Immunol., 178, 2000, 10.4049/jimmunol.178.4.2000

Liu, 2007, Origin of dendritic cells in peripheral lymphoid organs of mice, Nat. Immunol., 8, 578, 10.1038/ni1462

Madisen, 2010, A robust and high-throughput Cre reporting and characterization system for the whole mouse brain, Nat. Neurosci., 13, 133, 10.1038/nn.2467

Merad, 2002, Langerhans cells renew in the skin throughout life under steady-state conditions, Nat. Immunol., 3, 1135, 10.1038/ni852

Meredith, 2012, Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage, J. Exp. Med., 209, 1153, 10.1084/jem.20112675

Miyake, 2007, Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens, J. Clin. Invest., 117, 2268, 10.1172/JCI31990

Murray, 2011, Protective and pathogenic functions of macrophage subsets, Nat. Rev. Immunol., 11, 723, 10.1038/nri3073

Parwaresch, 1984, Origin and kinetics of resident tissue macrophages. Parabiosis studies with radiolabelled leucocytes, Cell Tissue Kinet., 17, 25

Qian, 2011, CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis, Nature, 475, 222, 10.1038/nature10138

Robb, 1995, Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5, Proc. Natl. Acad. Sci. USA, 92, 9565, 10.1073/pnas.92.21.9565

Sakagami, 2009, Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis, N. Engl. J. Med., 361, 2679, 10.1056/NEJMc0904077

Schulz, 2012, A lineage of myeloid cells independent of Myb and hematopoietic stem cells, Science, 336, 86, 10.1126/science.1219179

Serbina, 2006, Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2, Nat. Immunol., 7, 311, 10.1038/ni1309

Si, 2010, CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice, J. Clin. Invest., 120, 1192, 10.1172/JCI40310

Stanley, 1994, Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology, Proc. Natl. Acad. Sci. USA, 91, 5592, 10.1073/pnas.91.12.5592

Takahashi, 2001, Development and Differentiation of Macrophages and Related Cells: Historical Review and Current Concepts, J. Clin. Exp. Hematop., 41, 1, 10.3960/jslrt.41.1

Takahashi, 1989, Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study, J. Leukoc. Biol., 45, 87, 10.1002/jlb.45.2.87

Tarling, 1987, Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies, J. Leukoc. Biol., 42, 443, 10.1002/jlb.42.5.443

Thomas, 1976, Direct evidence for a bone marrow origin of the alveolar macrophage in man, Science, 192, 1016, 10.1126/science.775638

Trapnell, 2002, Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense, Annu. Rev. Physiol., 64, 775, 10.1146/annurev.physiol.64.090601.113847

Trapnell, 2003, Pulmonary alveolar proteinosis, N. Engl. J. Med., 349, 2527, 10.1056/NEJMra023226

Uchida, 2007, GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis, N. Engl. J. Med., 356, 567, 10.1056/NEJMoa062505

van Furth, 1968, The origin and kinetics of mononuclear phagocytes, J. Exp. Med., 128, 415, 10.1084/jem.128.3.415

Vinh, 2010, Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia, Blood, 115, 1519, 10.1182/blood-2009-03-208629

Virolainen, 1968, Hematopoietic origin of macrophages as studied by chromosome markers in mice, J. Exp. Med., 127, 943, 10.1084/jem.127.5.943

Wacker, 1986, Kinetics of Kupffer cells as shown by parabiosis and combined autoradiographic/immunohistochemical analysis, Virchows Arch. B Cell Pathol. Incl. Mol. Pathol., 51, 71, 10.1007/BF02899017