Timing of fluoride intake in relation to development of fluorosis on maxillary central incisors

Community Dentistry and Oral Epidemiology - Tập 34 Số 4 - Trang 299-309 - 2006
Liang Hong1, Steven M. Levy2,1, Barbara Broffitt1, John J. Warren1, Michael J. Kanellis3, J.S. Wefel3,4, Deborah V. Dawson1
1Department of Preventive and Community Dentistry
2Department of Epidemiology
3Department of Pediatric Dentistry
4Dows Institute for Dental Research, University of Iowa, Iowa City, IA, USA

Tóm tắt

Abstract –  Objectives:  Several studies have focused on the timing of fluoride intake relative to the development of dental fluorosis. This study reports the relationships of fluoride intake during the first 48 months of life with fluorosis on early‐erupting permanent teeth.Methods:  Subjects were followed from birth to 48 months with questionnaires every 3–4 months. Questionnaires gathered data on intakes from water, diet, supplements, and dentifrice to estimate total fluoride intake. Early‐erupting permanent teeth of 579 subjects were assessed for fluorosis using the Fluorosis Risk Index (FRI) at approximately age 9. Fluorosis cases were defined as having FRI definitive or severe fluorosis on both maxillary central incisors. Individuals with FRI questionable fluorosis were excluded. The importance of fluoride intake during different time periods was assessed using t‐tests and logistic regression.Results:  One hundred and thirty‐nine (24%) subjects had fluorosis on both maxillary central incisors. Mean fluoride intake per unit body weight (bw) ranged from 0.040 to 0.057 mg/kg bw, with higher intake during earlier time periods and relative stability after 16 months. In bivariate analyses, fluoride intakes during each of the first 4 years were individually significantly related to fluorosis on maxillary central incisors, with the first year most important (P < 0.01), followed by the second (P < 0.01), third (P < 0.01), and fourth year (P = 0.03). Multivariable logistic regression analyses showed that, after controlling only for the first year, the later years individually were still statistically significant. When all four time periods were in the model, the first (P < 0.01) and second years (P = 0.04) were still significant, but the third (P = 0.32) and fourth (P = 0.82) were not.Conclusions:  The first two years of life were most important to fluorosis development in permanent maxillary central incisors; however, this study also suggests the importance of other individual years.

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Tài liệu tham khảo

10.1111/j.1752-7325.1999.tb03276.x

Centers for Disease Control and Prevention, 2001, Recommendations for using fluoride to prevent and control dental caries in the United States, MMWR Morbid Mortal Wkly Rep, 50, 1

10.1111/j.1752-7325.1990.tb02138.x

10.1093/oxfordjournals.epirev.a017999

10.1111/j.1752-7325.1996.tb02387.x

Baelum V, 1987, Daily dose of fluoride and dental fluorosis, Tandlaegebladet, 91, 452

10.1159/000260892

10.1093/oxfordjournals.aje.a115448

Pendrys DG, 1990, Use of fluoride supplementation by children living in fluoridated communities, J Dent Children, 57, 343

10.1111/j.1752-7325.1991.tb02223.x

10.1111/j.1752-7325.1995.tb02376.x

10.1111/j.1752-7325.1996.tb02390.x

10.1177/00220345000790021001

10.1177/00220345860650071501

Levy SM, 1997, Patterns of fluoride dentifrice use among infants, Pediatr Dent, 19, 50

10.1111/j.1752-7325.2001.tb03369.x

10.1111/j.1752-7325.2003.tb03502.x

10.1111/j.1752-7325.1961.tb00373.x

Slayton RL, 2001, Prevalence of enamel hypoplasia and isolated opacities in the primary dentition, Pediatr Dent, 23, 32

10.1148/radiology.143.1.7063747

10.1177/154405910308200114

10.1111/j.1752-7325.2004.tb02754.x

10.1111/j.1600-0528.1982.tb00405.x

10.1093/oxfordjournals.aje.a117268

10.1093/oxfordjournals.aje.a009573

10.14219/jada.archive.1933.0205

10.2105/AJPH.29.6.590

10.1093/oxfordjournals.aje.a008819

10.1111/j.1752-7325.1999.tb03277.x

10.1159/000077766

10.1159/000260841

10.1016/0003-9969(88)90070-2

10.1177/00220345920710051601

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Community Dentistry and Oral Epidemiology

Tập 34 Số 4

299-309

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