Time to surgery and pathologic complete response after neoadjuvant chemoradiation in rectal cancer: A population study on 2094 patients

Sauer, 2004, Preoperative versus postoperative chemoradiotherapy for rectal cancer, N Engl J Med, 351, 1731, 10.1056/NEJMoa040694 van de Velde, 2014, EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum, Eur J Cancer, 50, 1.e1, 10.1016/j.ejca.2013.06.048 Capirci, 2008, Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients, Int J Radiat Oncol Biol Phys, 72, 99, 10.1016/j.ijrobp.2007.12.019 Valentini, 2011, Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials, J Clin Oncol, 29, 3163, 10.1200/JCO.2010.33.1595 Ortholan, 2012, Correlation in rectal cancer between clinical tumor response after neoadjuvant radiotherapy and sphincter or organ preservation: 10-year results of the Lyon R 96–02 randomized trial, Int J Radiat Oncol Biol Phys, 83, e165, 10.1016/j.ijrobp.2011.12.002 Zorcolo, 2012, Complete pathologic response after combined modality treatment for rectal cancer and long-term survival: a meta-analysis, Ann Surg Oncol, 19, 2822, 10.1245/s10434-011-2209-y Martin, 2012, Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer, Br J Surg, 99, 918, 10.1002/bjs.8702 Maas, 2016, Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data, Lancet Oncol, 11, 835, 10.1016/S1470-2045(10)70172-8 Wang, 2016, Effect of interval between neoadjuvant chemoradiotherapy and surgery on oncological outcome for rectal cancer: a systematic review and meta-analysis, Gastroenterol Res Pract, 2016, 10.1155/2016/6756859 Petrelli, 2016, Increasing the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer: a meta-analysis of published studies, Ann Surg, 263, 458, 10.1097/SLA.0000000000000368 Bosset, 2005, Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results—EORTC 22921, J Clin Oncol, 23, 5620, 10.1200/JCO.2005.02.113 Gerard, 2006, Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancers: results of FFCD 9203, J Clin Oncol, 24, 4620, 10.1200/JCO.2006.06.7629 Ngan, 2012, Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04, J Clin Oncol, 30, 3827, 10.1200/JCO.2012.42.9597 Rödel, 2007, Integration of novel agents into combined-modality treatment for rectal cancer patients, Strahlenther Onkol, 183, 227, 10.1007/s00066-007-9000-9 Gérard, 2010, Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2, J Clin Oncol, 28, 1638, 10.1200/JCO.2009.25.8376 Aschele, 2011, Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial, J Clin Oncol, 29, 2773, 10.1200/JCO.2010.34.4911 O'Connell, 2014, Capecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant Breast and Bowel Project trial R-04, J Clin Oncol, 32, 1927, 10.1200/JCO.2013.53.7753 Schmoll, 2014, Preoperative chemoradiotherapy and postoperative chemotherapy with capecitabine and oxaliplatin versus capecitabine alone in locally advanced rectal cancer: disease-free survival at interim analysis, Proc Am Soc Clin Oncol, 32 Rödel, 2015, Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial, Lancet Oncol, 16, 979, 10.1016/S1470-2045(15)00159-X Burbach, 2014, Impact of radiotherapy boost on pathological complete response in patients with locally advanced rectal cancer: a systematic review and meta-analysis, Radiother Oncol, 113, 1, 10.1016/j.radonc.2014.08.035 Appelt, 2013, Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy, Int J Radiat Oncol Biol Phys, 85, 74, 10.1016/j.ijrobp.2012.05.017 Francois, 1999, Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90–01 randomized trial, J Clin Oncol, 17, 2396, 10.1200/JCO.1999.17.8.2396 Tulchinsky, 2008, An interval >7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer, Ann Surg Oncol, 15, 2661, 10.1245/s10434-008-9892-3 Kalady, 2009, Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer, Ann Surg, 250, 582, 10.1097/SLA.0b013e3181b91e63 Sloothaak, 2013, Optimal time interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer, Br J Surg, 100, 933, 10.1002/bjs.9112 Moore, 2004, Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection, Dis Colon Rectum, 47, 279, 10.1007/s10350-003-0062-1 Dhadda, 2009, Regression of rectal cancer with radiotherapy with or without concurrent capecitabine – optimising the timing of surgical resection, Clin Oncol (R Coll Radiol), 21, 23, 10.1016/j.clon.2008.10.011 Probst, 2015, Extended intervals after neoadjuvant therapy in locally advanced rectal cancer: The key to improved tumor response and potential organ preservation, J Am Coll Surg, 221, 430, 10.1016/j.jamcollsurg.2015.04.010 Kerr, 2008, Delaying surgery after neoadjuvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis, Br J Surg, 95, 1534, 10.1002/bjs.6377 Tran, 2006, Evaluation of safety of increased time interval between chemoradiation and resection for rectal cancer, Am J Surg, 192, 873, 10.1016/j.amjsurg.2006.08.061 Garcia-Aguilar, 2015, Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: A multicentre, phase 2 trial, Lancet Oncol, 16, 957, 10.1016/S1470-2045(15)00004-2 Kwak, 2016, Timely tumor response analysis after preoperative chemoradiotherapy and curative surgery in locally advanced rectal cancer: A multi-institutional study for optimal surgical timing in rectal cancer, Radiother Oncol, 119, 512, 10.1016/j.radonc.2016.03.017 R Core Team (2016). R: a language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria. URL: https://www.R-project.org/. Verseveld, 2015, Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study), Br J Surg, 102, 853, 10.1002/bjs.9809 Habr-Gama, 2008, Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome?, Int J Radiat Oncol Biol Phys, 71, 1181, 10.1016/j.ijrobp.2007.11.035 Rödel, 2016, Rectal cancer: Neoadjuvant chemoradiotherapy, Best Pract Res Clin Gastroenterol, 30, 629, 10.1016/j.bpg.2016.06.004 Barreto, 2017, Timing of rectal cancer surgery following neoadjuvant chemoradiation: how close are we to striking an equipoise?, Future Oncol, 13, 303, 10.2217/fon-2016-0478 Lefevre, 2016, Effect of interval (7 or 11 weeks) between neoadjuvant radiochemotherapy and surgery on complete pathologic response in rectal cancer: a multicenter, randomized, controlled trial (GRECCAR-6), J Clin Oncol, 10.1200/JCO.2016.67.6049 Evans, 2016, Results of a prospective randomised control 6 vs 12 trial: Is greater tumour downstaging observed on post treatment MRI if surgery is delayed to 12-weeks versus 6-weeks after completion of neoadjuvant chemoradiotherapy?, Ann Oncol, 27, 4520 Cotte, 2016, Pathologic response, when increased by longer interval, is a marker but not the cause of good prognosis in rectal cancer: 17-year follow-up of the Lyon R90–01 randomized trial, Int J Radiat Oncol Biol Phys, 94, 544, 10.1016/j.ijrobp.2015.10.061 Friso, 2012, Retto-Capitolo 5, 119