Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall response

Journal of Pharmacokinetics and Pharmacodynamics - Tập 44 Số 5 - Trang 403-414 - 2017
Hongshan Li1, Jingyu Yu1, Chao Liu1, Jiang Liu1, Sriram Subramaniam1, Hong Zhao1, Gideon M. Blumenthal1, David C. Turner2, Claire Li2, Malidi Ahamadi2, Rik de Greef3, Manash Chatterjee2, Anna G. Kondic2, Julie Stone2, Brian Booth1, Patricia Keegan1, Atiqur Rahman1, Yaning Wang4,1
1Food and Drug Administration, Silver Spring, USA
2Merck & Co., Inc., Kenilworth, USA
3Quantitative Solutions, A Certara Company, Oss, The Netherlands
4Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, USA

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