Rối loạn cảm xúc theo thời gian ở bệnh nhân cai nghiện có rối loạn sử dụng methylphenidate

BMC Psychiatry - Tập 22 - Trang 1-7 - 2022
Jie Xu1,2,3, Yi Zhang4, Nan Wang1, Pei Sun3, Fuqiang Mao1, Ti-Fei Yuan4,5,6
1Department of Psychiatry and Psychology, Tianjin Medical University, Tianjin, China
2Beijing Gaoxin Hospital, Beijing, China
3Department of Psychology, Tsinghua University, Beijing, China
4Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China
5Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
6Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China

Tóm tắt

Methylphenidate (MPH), còn được gọi là Ritalin, được sử dụng để điều trị rối loạn tăng động giảm chú ý (ADHD). Với những báo cáo thỉnh thoảng về các đối tượng gặp phải rối loạn sử dụng methylphenidate (MPHUD), có rất ít nghiên cứu phân tích những thay đổi thần kinh tâm lý trong quần thể này. Nghiên cứu này nhằm đánh giá các kết quả lâm sàng của những cá nhân bị MPHUD. Chúng tôi đã phân tích hồi cứu 61 bệnh nhân sử dụng MPH (tuổi từ 16–27) nhập viện vào chương trình phục hồi chức năng nghiện thuốc của Bệnh viện Gaoxin Bắc Kinh từ tháng 1 năm 2017 đến tháng 3 năm 2019. Lịch sử sử dụng thuốc và thang điểm động lực nghiện thuốc đã được thu thập tại thời điểm nhập viện. Các bác sĩ lâm sàng đã đánh giá Thang điểm đánh giá trầm cảm Hamilton, Thang điểm đánh giá lo âu Hamilton và tiêu chí rối loạn sử dụng chất kích thích theo DSM-5 mỗi tuần trong suốt 4 tuần của chương trình phục hồi chức năng. Các phân tích tương quan được thực hiện giữa lịch sử sử dụng thuốc và rối loạn cảm xúc. Kết quả cho thấy giai đoạn vị thành niên là thời điểm cao nhất cho sự tiếp xúc với MPH, và 1/3 bệnh nhân có lần tiếp xúc đầu tiên với MPH từ cha mẹ của họ. Việc cai nghiện MPH đi kèm với các triệu chứng lo âu và trầm cảm nghiêm trọng, đồng thời giảm đáng kể sau bốn tuần điều trị. MPHUD có liên quan đến những rối loạn cảm xúc đáng kể, điều này yêu cầu một cuộc điều tra với mẫu lớn hơn.

Từ khóa

#methylphenidate #rối loạn sử dụng methylphenidate #rối loạn cảm xúc #trầm cảm #lo âu #nghiên cứu hồi cứu

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