Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures

BMC Neurology - Tập 23 - Trang 1-8 - 2023
Kazumi Tomioka1, Masahiro Nishiyama1, Shoichi Tokumoto1, Hiroshi Yamaguchi1, Kazunori Aoki2, Yusuke Seino2, Daisaku Toyoshima3, Hiroshi Kurosawa2, Hiroko Tada4, Hiroshi Sakuma4, Kandai Nozu1, Azusa Maruyama3, Ryojiro Tanaka5, Kazumoto Iijima1, Hiroaki Nagase1
1Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
2Department of Pediatric Critical Care Medicine, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
3Department of Neurology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
4Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
5Department of Emergency and General Pediatrics, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan

Tóm tắt

Cytokine levels have been measured in acute encephalopathy (AE) to determine its pathology or as a diagnostic biomarker to distinguish it from febrile seizures (FS); however, the dynamics of cytokine level changes have not yet been fully captured in these two neurological manifestations. Thus, we aimed to explore the time course of serum cytokine level changes within 72 h after onset in AE and FS. We retrospectively measured cytokine level in residual serum samples at multiple timepoints in seven children whose final diagnoses were AE or FS. The levels of 13 cytokines appeared to increase immediately after onset and peaked within 12–24 h after onset: interleukin (IL)-1β, IL-4 IL-5, IL-6, IL-8, IL-10, IL-17, eotaxin, fibroblast growth factor, granulocyte colony-stimulating factor, interferon gamma, interferon-inducible protein-10, and macrophage chemoattractant protein-1. There were no dynamic changes in the levels of three cytokines (IL-1 receptor agonist, macrophage inflammatory protein-1α, and platelet-derived growth factor-bb) 72 h after onset. Levels of some cytokines decreased to around control levels within 48 h after onset: IL-1β, IL-4, IL-5, IL-17, fibroblast growth factor, and interferon gamma. The levels of most cytokines appeared to be higher in AE, especially in hemorrhagic shock encephalopathy syndrome, than in FS. Cytokine levels in both AE and FS change dynamically, such as the levels of several cytokines increased within a few hours after onset and decreased at 12–24 h after onset. Therefore, it will be desirable to make clinical decisions regarding the administration of anti-inflammatory therapy in 24 h after onset in AE.

Tài liệu tham khảo

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