TiO2 genotoxicity: An update of the results published over the last six years

Marie Carriere1, Marie-Edith Arnal1, Thierry Douki1
1Univ. Grenoble Grenoble Alpes, CEA, CNRS, IRIG-SyMMES, CIBEST, 38000, Grenoble, France

Tài liệu tham khảo

Brown, 2019 2011, Recommendation on the definition of a nanomaterial Jovanovic, 2015, Critical review of public health regulations of titanium dioxide, a human food additive, Integr. Environ. Assess. Manag., 11, 10, 10.1002/ieam.1571 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), 2016, Re-evaluation of titanium dioxide (E 171) as a food additive, EFSA J., 14, 4545 Weir, 2012, Titanium dioxide nanoparticles in food and personal care products, Environ. Sci. Technol., 46, 2242, 10.1021/es204168d Muhle, 1991, Pulmonary response to toner upon chronic inhalation exposure in rats, Fundam. Appl. Toxicol., 17, 280, 10.1016/0272-0590(91)90219-T Lee, 1985, Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years, Toxicol. Appl. Pharmacol., 79, 179, 10.1016/0041-008X(85)90339-4 NIOSH, 2011 ACGIH, 2001, Titanium dioxide Guadagnini, 2015, Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests, Nanotoxicology, 9, 13, 10.3109/17435390.2013.829590 Magdolenova, 2014, Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles, Nanotoxicology, 8, 233, 10.3109/17435390.2013.773464 Shi, 2013, Titanium dioxide nanoparticles: a review of current toxicological data, Part. Fibre Toxicol., 10, 15, 10.1186/1743-8977-10-15 Gonzalez, 2016, Biomonitoring of genotoxic effects for human exposure to nanomaterials: the challenge ahead, Mutat. Res., 768, 14, 10.1016/j.mrrev.2016.03.002 Driscoll, 1997, Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells, Carcinogenesis, 18, 423, 10.1093/carcin/18.2.423 Rehn, 2003, Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: untreated and surface treated, Toxicol. Appl. Pharmacol., 189, 84, 10.1016/S0041-008X(03)00092-9 Saber, 2012, Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers, Nanotoxicology, 6, 453, 10.3109/17435390.2011.587900 Naya, 2012, In vivo genotoxicity study of titanium dioxide nanoparticles using comet assay following intratracheal instillation in rats, Regul. Toxicol. Pharmacol., 62, 1, 10.1016/j.yrtph.2011.12.002 Lindberg, 2012, Genotoxicity of inhaled nanosized TiO(2) in mice, Mutat. Res., 745, 58, 10.1016/j.mrgentox.2011.10.011 Borm, 2019, The hazards and risks of inhaled poorly soluble particles - where do we stand after 30 years of research?, Part. Fibre Toxicol., 16, 11, 10.1186/s12989-019-0294-4 Saber, 2019, Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation, Part. Fibre Toxicol., 16, 44, 10.1186/s12989-019-0330-4 Relier, 2017, Study of TiO2 P25 nanoparticles genotoxicity on lung, blood, and liver cells in lung overload and non-overload conditions after repeated respiratory exposure in rats, Toxicol. Sci., 156, 527 Hadrup, 2017, Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles, Mutagenesis, 32, 581, 10.1093/mutage/gex042 Wallin, 2017, Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary exposure by instillation in mice, Mutagenesis, 32, 47, 10.1093/mutage/gew046 Chen, 2014, Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro, Toxicol. Lett., 226, 314, 10.1016/j.toxlet.2014.02.020 Bettini, 2017, Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon, Sci. Rep., 7, 40373, 10.1038/srep40373 De Robertis, 2011, The AOM/DSS murine model for the study of colon carcinogenesis: from pathways to diagnosis and therapy studies, J. Carcinog., 10, 9, 10.4103/1477-3163.78279 Blevins, 2019, Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2), Food Chem. Toxicol., 133, 10.1016/j.fct.2019.110793 Winkler, 2018, Critical review of the safety assessment of titanium dioxide additives in food, J. Nanobiotechnol., 16, 51, 10.1186/s12951-018-0376-8 Dorier, 2017, Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress, Nanotoxicology, 11, 751 Dorier, 2019, The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells in vitro, Environ. Sci. Nano, 6, 1549, 10.1039/C8EN01188E Dorier, 2019, Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells, Mutat. Res., 845 Lundqvist, 2008, Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts, Proc. Natl. Acad. Sci. USA, 105, 14265, 10.1073/pnas.0805135105 Sasso, 2018, Dietary components that counteract the increased risk of colorectal cancer related to red meat consumption, Int. J. Food Sci. Nutr., 69, 536, 10.1080/09637486.2017.1393503 Charles, 2018, Assessment of the in vitro genotoxicity of TiO2 nanoparticles in a regulatory context, Nanotoxicology, 12, 357, 10.1080/17435390.2018.1451567 Huang, 2009, Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure, Toxicol. Appl. Pharmacol., 241, 182, 10.1016/j.taap.2009.08.013 Biola-Clier, 2020, Titanium dioxide nanoparticles alter the cellular phosphoproteome in A549 cells, Nanomaterials, 10, 10.3390/nano10020185 Oh, 2014, Endocytosis and exocytosis of nanoparticles in mammalian cells, Int. J. Nanomed., 9, 51 Di Virgilio, 2010, Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells, J. Hazard. Mater., 177, 711, 10.1016/j.jhazmat.2009.12.089 Hartmann, 2015, Techniques and protocols for dispersing nanoparticle powders in aqueous media-is there a rationale for harmonization?, J. Toxicol. Environ. Health Part B, 18, 299, 10.1080/10937404.2015.1074969 Jugan, 2012, Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells, Nanotoxicology, 6, 501, 10.3109/17435390.2011.587903 El Yamani, 2017, In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment, Mutagenesis, 32, 117, 10.1093/mutage/gew060 Di Bucchianico, 2017, Genotoxicity of TiO2 nanoparticles assessed by mini-gel comet assay and micronucleus scoring with flow cytometry, Mutagenesis, 32, 127, 10.1093/mutage/gew030 Vales, 2015, Long-term exposures to low doses of titanium dioxide nanoparticles induce cell transformation, but not genotoxic damage in BEAS-2B cells, Nanotoxicology, 9, 568, 10.3109/17435390.2014.957252 Armand, 2016, Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents, Nanotoxicology, 10, 913, 10.3109/17435390.2016.1141338 Armand, 2016, Molecular responses of alveolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: a proteomic view, J. Proteomics, 134, 163, 10.1016/j.jprot.2015.08.006 Singh, 2006, Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer, PLoS Med., 3, e420, 10.1371/journal.pmed.0030420 Biola-Clier, 2017, Comparison of the DNA damage response in BEAS-2B and A549 cells exposed to titanium dioxide nanoparticles, Mutagenesis, 32, 161, 10.1093/mutage/gew055 Collins, 2017, High throughput toxicity screening and intracellular detection of nanomaterials, Wiley interdisciplinary reviews, Nanomed. Nanobiotechnol., 9, 10.1002/wnan.1413 Jain, 2017, Impact of anatase titanium dioxide nanoparticles on mutagenic and genotoxic response in Chinese hamster lung fibroblast cells (V-79): the role of cellular uptake, Food Chem. Toxicol., 105, 127, 10.1016/j.fct.2017.04.005 Gerloff, 2009, Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells, Nanotoxicology, 3, 355, 10.3109/17435390903276933 Gerloff, 2012, Distinctive toxicity of TiO2 Rutile/Anatase mixed phase nanoparticles on Caco-2 cells, Chem. Res. Toxicol., 25, 646, 10.1021/tx200334k Zijno, 2015, Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells, Toxicol. Vitr., 29, 1503, 10.1016/j.tiv.2015.06.009 Dorier, 2015, Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells, Nanoscale, 7, 7352, 10.1039/C5NR00505A Vila, 2018, Titanium dioxide nanoparticles translocate through differentiated Caco-2 cell monolayers, without disrupting the barrier functionality or inducing genotoxic damage, J. Appl. Toxicol., 38, 1195, 10.1002/jat.3630 Garcia-Rodriguez, 2018, Effects of differently shaped TiO2NPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier, Part. Fibre Toxicol., 15, 33, 10.1186/s12989-018-0269-x Lesuffleur, 1993, Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations, J. Cell Sci., 106, 771, 10.1242/jcs.106.3.771 Proquin, 2017, Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions, Mutagenesis, 32, 139, 10.1093/mutage/gew051 Kansara, 2015, TiO2 nanoparticles induce DNA double strand breaks and cell cycle arrest in human alveolar cells, Environ. Mol. Mutagen., 56, 204, 10.1002/em.21925 Hanot-Roy, 2016, Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro, Toxicol. Vitr., 33, 125, 10.1016/j.tiv.2016.01.013 Ghosh, 2017, Cyto-genotoxic and DNA methylation changes induced by different crystal phases of TiO2-np in bronchial epithelial (16-HBE) cells, Mutat. Res., 796, 1, 10.1016/j.mrfmmm.2017.01.003 Stoccoro, 2017, Multiple endpoints to evaluate pristine and remediated titanium dioxide nanoparticles genotoxicity in lung epithelial A549 cells, Toxicol. Lett., 276, 48, 10.1016/j.toxlet.2017.05.016 Thongkam, 2017, Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines, Mutagenesis, 32, 105, 10.1093/mutage/gew056 Gea, 2019, Shape-engineered titanium dioxide nanoparticles (TiO2-NPs): cytotoxicity and genotoxicity in bronchial epithelial cells, Food Chem. Toxicol., 127, 89, 10.1016/j.fct.2019.02.043 Botelho, 2014, Effects of titanium dioxide nanoparticles in human gastric epithelial cells in vitro, Biomed. Pharmacother., 68, 59, 10.1016/j.biopha.2013.08.006 Donner, 2016, In vivo micronucleus studies with 6 titanium dioxide materials (3 pigment-grade & 3 nanoscale) in orally-exposed rats, Regul. Toxicol. Pharmacol., 74, 64, 10.1016/j.yrtph.2015.11.003