Thyroid hormone receptors: lessons from knockout and knock-in mutant mice

Yen, 2001, Physiological and molecular basis of thyroid hormone action, Physiol. Rev., 81, 1097, 10.1152/physrev.2001.81.3.1097

Wu, 2000, Gene regulation by thyroid hormone, Trends Endocrinol. Metab., 11, 207, 10.1016/S1043-2760(00)00263-0

Robinson-Rechavi, 2001, How many nuclear hormone receptors are there in the human genome?, Trends Genet., 17, 554, 10.1016/S0168-9525(01)02417-9

Williams, 2000, Cloning and characterization of two novel thyroid hormone receptor β isoforms, Mol. Cell. Biol., 20, 8329, 10.1128/MCB.20.22.8329-8342.2000

Casas, 1999, A variant form of the nuclear triiodothyronine receptor c-ErbAα1 plays a direct role in regulation of mitochondrial RNA synthesis, Mol. Cell. Biol., 19, 7913, 10.1128/MCB.19.12.7913

Chassande, 1997, Identification of transcripts initiated from an internal promoter in the c-erbA α locus that encode inhibitors of retinoic acid receptor-α and triiodothyronine receptor activities, Mol. Endocrinol., 11, 1278, 10.1210/me.11.9.1278

Prost, 1988, Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries, Nucleic Acids Res., 16, 6248, 10.1093/nar/16.13.6248

Plateroti, 1999, Involvement of T3Rα- and β-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development, Gastroenterology, 116, 1367, 10.1016/S0016-5085(99)70501-9

Zandieh Doulabi, 2002, TRβ1 protein is preferentially expressed in the pericentral zone of rat liver and exhibits marked diurnal variation, Endocrinology, 143, 979, 10.1210/en.143.3.979

Salto, 2001, Ablation of TRα2 and a concomitant overexpression of α1 yields a mixed hypo- and hyperthyroid phenotype in mice, Mol. Endocrinol., 15, 2115, 10.1210/me.15.12.2115

Wikstrom, 1998, Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor α1, EMBO J., 17, 455, 10.1093/emboj/17.2.455

Fraichard, 1997, The TRα gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production, EMBO J., 16, 4412, 10.1093/emboj/16.14.4412

Gauthier, 1999, Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post-natal development, EMBO J., 18, 623, 10.1093/emboj/18.3.623

Preitner, 2002, The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator, Cell, 110, 251, 10.1016/S0092-8674(02)00825-5

Weiss, 2000, Resistance to thyroid hormone, Rev. Endocr. Metab. Disord., 1, 97, 10.1023/A:1010072605757

Hashimoto, 2001, An unliganded thyroid hormone receptor causes severe neurological dysfunction, Proc. Natl. Acad. Sci. U. S. A., 98, 3998, 10.1073/pnas.051454698

Kaneshige, 2000, Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone, Proc. Natl. Acad. Sci. U. S. A., 97, 13209, 10.1073/pnas.230285997

Kaneshige, 2001, A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice, Proc. Natl. Acad. Sci. U. S. A., 98, 15095, 10.1073/pnas.261565798

Itoh, 2001, Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene, Proc. Natl. Acad. Sci. U. S. A., 98, 9913, 10.1073/pnas.171319498

Tinnikov, 2002, Retardation of post-natal development caused by a negatively acting thyroid receptor α1, EMBO J., 21, 1, 10.1093/emboj/cdf523

Forrest, 2002, Neurodevelopmental control by thyroid hormone receptors, Curr. Opin. Neurobiol., 12, 49, 10.1016/S0959-4388(02)00289-1

Forrest, 2000, Functions of thyroid hormone receptors in mice, Thyroid, 10, 41, 10.1089/thy.2000.10.41

Brent, 2000, Tissue-specific actions of thyroid hormone: insights from animal models, Rev. Endocr. Metab. Disord., 1, 27, 10.1023/A:1010056202122

Mansouri, 1998, Follicular cells of the thyroid gland require Pax8 gene function, Nat. Genet., 19, 87, 10.1038/ng0598-87

Hadj-Sahraoui, 2000, Hypothyroidism prolongs mitotic activity in the post-natal mouse brain, Neurosci. Lett., 280, 79, 10.1016/S0304-3940(00)00768-0

Billon, 2001, Role of thyroid hormone receptors in timing oligodendrocyte differentiation, Dev. Biol., 235, 110, 10.1006/dbio.2001.0293

Morte, 2002, Deletion of the thyroid hormone receptor α1 prevents the structural alterations of the cerebellum induced by hypothyroidism, Proc. Natl. Acad. Sci. U. S. A., 99, 3985, 10.1073/pnas.062413299

Harvey, 2002, Molecular mechanisms of thyroid hormone effects on bone growth and function, Mol. Genet. Metab., 75, 17, 10.1006/mgme.2001.3268

Plateroti, 2001, Functional interference between thyroid hormone receptor α (TRα) and natural truncated TRΔα isoforms in the control of intestine development, Mol. Cell. Biol., 21, 4761, 10.1128/MCB.21.14.4761-4772.2001

Forrest, 1996, Thyroid hormone receptor β is essential for development of auditory function, Nat. Genet., 13, 354, 10.1038/ng0796-354

Rusch, 1998, Thyroid hormone receptor β-dependent expression of a potassium conductance in inner hair cells at the onset of hearing, Proc. Natl. Acad. Sci. U. S. A., 95, 15758, 10.1073/pnas.95.26.15758

Ng, 2001, A thyroid hormone receptor that is required for the development of green cone photoreceptors, Nat. Genet., 27, 94, 10.1038/83829

Abel, 1999, Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system, J. Clin. Invest., 104, 291, 10.1172/JCI6397

Johansson, 1999, Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-β or both α1 and β, Am. J. Physiol., 276, H2006

Dellovade, 2000, The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors, Nat. Neurosci., 3, 472, 10.1038/74846

Zhang, 2002, Differential expression of thyroid hormone receptor isoforms dictates the dominant negative activity of mutant β receptor, Mol. Endocrinol., 16, 2077, 10.1210/me.2002-0080

Gothe, 1999, Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary–thyroid axis, growth, and bone maturation, Genes Dev., 13, 1329, 10.1101/gad.13.10.1329

Baas, 2002, Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors, Proc. Natl. Acad. Sci. U. S. A., 99, 2907, 10.1073/pnas.052482299

Taneja, 1996, Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR β 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts, Proc. Natl. Acad. Sci. U. S. A., 93, 6197, 10.1073/pnas.93.12.6197

Gloss, 2001, Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor α or β, Endocrinology, 142, 544, 10.1210/en.142.2.544

Gullberg, 2002, Requirement for thyroid hormone receptor β in T3 regulation of cholesterol metabolism in mice, Mol. Endocrinol., 16, 1767, 10.1210/me.2002-0009

Glass, 2000, The coregulator exchange in transcriptional functions of nuclear receptors, Genes Dev., 14, 121, 10.1101/gad.14.2.121

Flamant, 2002, Congenital hypothyroid Pax8(−/−) mutant mice can be rescued by inactivating the TRα gene, Mol. Endocrinol., 16, 24, 10.1210/me.16.1.24

Ng, 2001, Suppression of the deafness and thyroid dysfunction in TRβ-null mice by an independent mutation in the thyroid hormone receptor α gene, Hum. Mol. Genet., 10, 2701, 10.1093/hmg/10.23.2701

Gauthier, 2001, Genetic analysis reveals different functions for the products of the thyroid hormone receptor α locus, Mol. Cell. Biol., 21, 4748, 10.1128/MCB.21.14.4748-4760.2001

Davis, 2000, Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR, J. Biol. Chem., 275, 38032, 10.1074/jbc.M002560200

Potter, 2001, The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor, Genes Dev., 15, 2687, 10.1101/gad.916701

Lin, 2002, Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors, J. Biol. Chem., 277, 28733, 10.1074/jbc.M203380200

Baniahmad, 1993, Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone, Proc. Natl. Acad. Sci. U. S. A., 90, 8832, 10.1073/pnas.90.19.8832

Lin, 1992, Phosphorylation stimulates the transcriptional activity of the human β1 thyroid hormone nuclear receptor, Proc. Natl. Acad. Sci. U. S. A., 89, 7737, 10.1073/pnas.89.16.7737

Pfahl, 1993, Nuclear receptor/AP-1 interaction, Endocr. Rev., 14, 651

Barrera-Hernandez, 1998, Thyroid hormone receptor is a negative regulator in p53-mediated signaling pathways, DNA Cell Biol., 17, 743, 10.1089/dna.1998.17.743

Lee, 1994, Thyroid hormone receptor-α inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem cells, Mol. Endocrinol., 8, 746, 10.1210/me.8.6.746

Weiss, 2002, Thyroid function and effect of aging in combined hetero/homozygous mice deficient in thyroid hormone receptors α and β genes, J. Endocrinol., 172, 177, 10.1677/joe.0.1720177

Weiss, 2002, Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency, Endocrinology, 143, 1554, 10.1210/en.143.4.1554

Arpin, 2000, Effects of TRα1 and TRα2 gene deletion on T and B lymphocyte development, J. Immunol., 164, 152, 10.4049/jimmunol.164.1.152

Sauer, 1998, Inducible gene targeting in mice using the Cre/lox system, Methods, 14, 381, 10.1006/meth.1998.0593

Oberste-Berghaus, 2000, Thyroid hormone-independent interaction between the thyroid hormone receptor β2 amino terminus and coactivators, J. Biol. Chem., 275, 1787, 10.1074/jbc.275.3.1787

Forrest, 1996, Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor β: evidence for tissue-specific modulation of receptor function, EMBO J., 15, 3006, 10.1002/j.1460-2075.1996.tb00664.x

Liu, 2002, A targeted thyroid hormone receptor α gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells, Endocrinology, 143, 2664, 10.1210/en.143.7.2664