Thyroid Hormone Controls Breast Cancer Cell Movement via Integrin αV/β3/SRC/FAK/PI3-Kinases

Marina Inés Flamini1, Ivonne Denise Uzair2, Gisela E. Pennacchio3, Flavia Judith Neira2, Joselina Magali Mondaca2, F. Darío Cuello-Carrión4, Graciela A. Jahn3, Tommaso Simoncini5, Angel Matías Sanchez2
1Laboratorio de Biología Tumoral. Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina
2Laboratorio de Transducción de Señales y Movimiento Celular. Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Ruiz Leal s/n. Parque Gral. San Martin CC855, 5500, Mendoza, Argentina
3Laboratorio de Reproducción y Lactancia. Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina
4Laboratorio de Oncología. Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina
5Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Clinical and Experimental Medicine, University of Pisa, 56100, Pisa, Italy

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Siegel R et al (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61(4):212–236

Stevanovic A, Lee P, Wilcken N (2006) Metastatic breast cancer. Aust Fam Physician 35(5):309–312

Acconcia F, Barnes CJ, Kumar R (2006) Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells. Endocrinology 147(3):1203–1212

Wu X et al (2004) Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem 279(10):9565–9576

Sanchez AM et al (2011) Estrogen receptor-{alpha} promotes endothelial cell motility through focal adhesion kinase. Mol Hum Reprod 17(4):219–226

McLean GW et al (2005) The role of focal-adhesion kinase in cancer—a new therapeutic opportunity. Nat Rev Cancer 5(7):505–515

Sanchez AM et al (2010) Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP. Mol Endocrinol 24(11):2114–2125

Sanchez AM et al (2013) Effects of progesterone and medroxyprogesterone on actin remodeling and neuronal spine formation. Mol Endocrinol 27(4):693–702

Fu XD et al (2010) Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. Endocr Relat Cancer 17(2):431–443

van Nimwegen MJ, van de Water B (2007) Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol 73(5):597–609

Watermann DO et al (2005) Specific induction of pp125 focal adhesion kinase in human breast cancer. Br J Cancer 93(6):694–698

Zhao J, Guan JL (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28(1–2):35–49

Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9(8):550–562

Kim LC, Song L, Haura EB (2009) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6(10):587–595

Flamini MI et al (2011) Estrogen regulates endometrial cell cytoskeletal remodeling and motility via focal adhesion kinase. Fertil Steril 95(2):722–726

Luo M, Guan JL (2010) Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett 289(2):127–139

Arold ST (2011) How focal adhesion kinase achieves regulation by linking ligand binding, localization and action. Curr Opin Struct Biol 21(6):808–813

Bolos V et al (2010) The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco Targets Ther 3:83–97

Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18(5):516–523

Vultur A et al (2008) SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther 7(5):1185–1194

McLean BA et al (2013) PI3K inhibitors as novel cancer therapies: implications for cardiovascular medicine. J Card Fail 19(4):268–282

Luo J, Manning BD, Cantley LC (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4(4):257–262

Stephens L, Williams R, Hawkins P (2005) Phosphoinositide 3-kinases as drug targets in cancer. Curr Opin Pharmacol 5(4):357–365

Guigon CJ et al (2011) Mutation of thyroid hormone receptor-beta in mice predisposes to the development of mammary tumors. Oncogene 30(30):3381–3390

Moeller LC, Fuhrer D (2013) Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective. Endocr Relat Cancer 20(2):R19–R29

Ditsch N et al (2013) Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer. Histol Histopathol 28(2):227–237

Cristofanilli M et al (2005) Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer 103(6):1122–1128

Tosovic A et al (2010) Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women. Breast Cancer Res 12(3):R33

Hercbergs AH, Ashur-Fabian O, Garfield D (2010) Thyroid hormones and cancer: clinical studies of hypothyroidism in oncology. Curr Opin Endocrinol Diabetes Obes 17(5):432–436

Furuya F et al (2009) Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. Steroids 74(7):628–634

Kavok NS, Krasilnikova OA, Babenko NA (2001) Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone. BMC Cell Biol 2:5

Hiroi Y et al (2006) Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A 103(38):14104–14109

Flamini, M.I., et al. 2014 Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med

Lin HY et al (1999) Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells. Am J Phys 276(5 Pt 1):C1014–C1024

Lin HY et al (2009) L-thyroxine vs. 3,5,3′-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Am J Physiol Cell Physiol 296(5):C980–C991

Desgrosellier JS et al (2009) An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med 15(10):1163–1169

Meng R et al (2011) Crosstalk between integrin alphavbeta3 and estrogen receptor-alpha is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. PLoS One 6(11):e27547

Sporn MB (1996) The war on cancer. Lancet 347(9012):1377–1381

Aranda A et al (2009) Thyroid receptor: roles in cancer. Trends Endocrinol Metab 20(7):318–324

Goodman AD, Hoekstra SJ, Marsh PS (1980) Effects of hypothyroidism on the induction and growth of mammary cancer induced by 7,12-dimethylbenz(a)anthracene in the rat. Cancer Res 40(7):2336–2342

Martinez-Iglesias O et al (2009) Hypothyroidism enhances tumor invasiveness and metastasis development. PLoS One 4(7):e6428

Zhang J, Lazar MA (2000) The mechanism of action of thyroid hormones. Annu Rev Physiol 62:439–466

Freindorf M et al (2012) Combined QM/MM study of thyroid and steroid hormone analogue interactions with alphavbeta3 integrin. J Biomed Biotechnol 2012:959057

Davis PJ et al (2011) Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. Annu Rev Pharmacol Toxicol 51:99–115

Liu ZJ, Semenza GL, Zhang HF (2015) Hypoxia-inducible factor 1 and breast cancer metastasis. J Zhejiang Univ Sci B 16(1):32–43

Cohen, K., et al. 2014 Thyroid hormone regulates adhesion, migration and matrix metalloproteinase 9 activity via alphavbeta3 integrin in myeloma cells. Oncotarget

Reiske HR et al (1999) Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem 274(18):12361–12366

Thamilselvan V, Craig DH, Basson MD (2007) FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 21(8):1730–1741

Leonard JL, Farwell AP (1997) Thyroid hormone-regulated actin polymerization in brain. Thyroid 7(1):147–151

Cheng SY, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31(2):139–170

Heublein S et al (2015) Thyroid hormone receptors predict prognosis in BRCA1 associated breast cancer in opposing ways. PLoS One 10(6):e0127072