Thymulin, a zinc-dependent hormone

Jean‐François Bach1, Mireille Dardenne1
1INSERM 25, Hôpital Necker, Paris, France.

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Bach J F: Thymulin (FTS-Zn).Clin Immun Allergy 3, 1 (1983).

Bach J F, Dardenne M, Pléau J M, Pléau Rosa: Biochemical characterization of a serum thymic hormone.Nature 266, 55 (1977).

Pléau J M, Dardenne M, Blouquit Y, Bach J F: Structural study of circulating thymic factor: a peptide isolated from pig serum. II. Aminoacid sequence.J biol Chem 252, 8045 (1977).

Dardenne M, Pléau J M, Nabarra B, Lefrancier P, Derien M, Choay J, Bach J F: Contribution of zinc and other metals to the biological activity of the serum thymic factor.Proc natn Acad Sci USA 79, 5370 (1982).

Cung M T, Marraud M, Lefrancier P, Dardenne M, Bach J F, Laussac J P: NMR study of a lymphocyte differentiating thymic factor. An investigation of the Zn (II)-nonapeptide complexes (thymulin).J biol Chem 263, 5574 (1988).

Savino W, Dardenne M, Pepiernik M, Bach J F: Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies.J exp Med 156, 628 (1982).

Bordigoni P, Faure G, Bene M C, Dardenne M, Bach J F, Duheille J F, Olive D: Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS).Lancet ii, 293 (1982).

Amor B, Dougados M, Mery C, De Gery A, Choay J, Dardenne M, Bach J F: Thymulin (FTS) in rheumatoid arthritis.Arthritis Rheum 27, 117 (1984).