Thymic cancer mimicking a metastasis of testicular seminoma
Tóm tắt
A 48-year-old man presented with a left testicular mass. Computed tomography showed an anterior mediastinal tumor, with positive uptake in positron emission tomography images. Radical orchiectomy was performed; the histology was seminoma. Thus, a diagnosis of testicular seminoma with thymic metastasis (stage III) was made and he underwent four courses of bleomycin, etoposide and cisplatin chemotherapy. The tumor shrank from 2.5 to 1.4 cm, but grew to 1.9 cm 1 month after the fourth course. He underwent two courses of paclitaxel, ifosfamide and cisplatin chemotherapy, followed by the resection of mediastinal tumor, the histopathological diagnosis of which was thymic cancer. Adjuvant radiation therapy was administered and no recurrences were evident at 1 year postoperatively. This is the first reported case of thymic cancer coexisting with stage I testicular seminoma.
Tài liệu tham khảo
Shin DJ, Kim JS, Kim do Y et al (2013) Late relapse of testicular seminoma in the posterior mediastinum. Clin Imaging 37:406–408
Williams MP, Husband JE, Heron CW (1987) Intrathoracic manifestations of metastatic testicular seminoma: a comparison of chest radiographic and CT findings. AJR 149:473–475
Mead GM, Fossa SD, Oliver RT et al (2011) Randomized trials in 2466 patients with stage I seminoma: patterns of relapse and follow-up. J Nati Cancer Inst 103:241–249
Fizazi K, Tjulandin S, Salvioni R et al (2001) Viable malignant cells after primary chemotherapy for disseminated nonseminomatous germ cell tumors: prognostic factors and role of postsurgery chemotherapy—results from an international study group. J Clin Oncol 19:2647–2657
Engels EA, Pfeiffer RM et al (2003) Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies. Int J Cancer 105:546–551
Eng TY, Fuller CD, Jagirdar J et al (2004) Thymic carcinoma: state of the art review. Int J Radiat Oncol Biol Phys 59:654–664
Berardi R, De Lisa M, Pagliaretta S et al (2014) Thymic neoplasms: an update on the use of chemotherapy and new targeted therapies. A literature review. Cancer Treat Rev 40:495–506