Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials

European Journal of Cancer - Tập 82 - Trang 45-55 - 2017
Dirk Schadendorf1,2, Georgina V. Long3,4,5, Daniil Stroiakovski6, Boguslawa Karaszewska7, Axel Hauschild8, Evgeny Levchenko9, Vanna Chiarion-Sileni10, Jacob Schachter11, Claus Garbe12, Caroline Dutriaux13, Helen Gogas14, Mario Mandalà15, John B.A.G. Haanen16, Céleste Lebbé17, Andrzej Mackiewicz18, Piotr Rutkowski19, Jean-Jacques Grob20, Paul Nathan21, Antoni Ribas22, Michael A. Davies23
1Department of Dermatology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
2German Cancer Consortium, 69117 Heidelberg, Germany
3Melanoma Institute Australia, The University of Sydney, NSW, Australia
4Mater Hospital, North Sydney, NSW, Australia
5Royal North Shore Hospital, St Leonards, NSW, Australia
6Moscow City Oncology Hospital No 62, Moscow 143423, Russia
7Przychodnia Lekarska KOMED, Wojska Polskiego 6, 62-500 Konin, Poland
8Department of Dermatology, University Medical Center Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany
9Petrov Research Institute of Oncology, 68 Leningradskaya Street, Saint Petersburg 197758, Russia
10Melanoma and Esophageal Oncology Unit, Veneto Oncology Institute–IRCCS, Via Gattamelata 64, 35128 Padova, Italy
11Oncology Division, Sheba Medical Center, Tel HaShomer, Emek HaEla St 1, Ramat Gan, Israel
12Department of Dermatology, University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany
13Service de Dermatologie et Dermatologie Pédiatrique, Hôpital Saint-André, 1 Rue Jean Burguet, 33000 Bordeaux, France
14First Department of Medicine, “Laiko” General Hospital, National and Kapodistrian University of Athens, Athens 157 72, Greece
15Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy
16Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
17APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris, France
18Department of Cancer Immunology, Poznan University of Medical Sciences, 15 Garbary Street, 61-866 Poznań, Poland
19Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland
20Department of Dermatology, University Hospital Center, Timone Hospital, Aix Marseille University, 264 Rue St Pierre, 13885 Marseille Cedex 05, France
21Mount Vernon Cancer Centre, Rickmansworth Road, HA6 2RN Northwood, UK
22Department of Medicine, Hematology/Oncology, UCLA Medical Center, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA, USA
23Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston 77030, TX, USA

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European Journal of Cancer

Tập 82

45-55

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