Three new xanthones from the leaves of Garcinia lancilimba

Journal of Natural Medicines - Tập 70 - Trang 173-178 - 2015
Yating Sun1, Dahong Li1, Cuicui Jia1, Chunmei Xue1, Jiao Bai1, Zhanlin Li1, Huiming Hua1
1Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Tóm tắt

Three new prenylated xanthones, garcinexanthones G−I (1–3), together with fifteen known ones (4–18) were identified from the leaves of Garcinia lancilimba. Their structures were determined by extensive spectroscopic analyses. Most of the compounds exhibited inhibitory effects against HL-60 (human leukemia), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines. Among them, compounds 7, 17, and 13 exhibited the most pronounced growth inhibitory activity against HL-60, A549, and MCF-7 cell lines with GI50 values of 1.68, 4.88, and 6.28 μM, respectively.

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