Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

Lab on a Chip - Tập 15 Số 1 - Trang 141-150
Jisoo Park1,2,3,4, Bo Kyeong Lee5,2,3,6,7, Gi Seok Jeong5,2,3,6,7, Jung Keun Hyun8,9,10,11,12, C. Justin Lee13,14,1,3,4, Sang‐Hoon Lee1,3,15,6,4
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Republic of Korea
2Korea University
3Republic of Korea
4Seoul 136-701
5College of Health Science
6School of Biomedical Engineering, College of Health Science, Korea University, Seoul 136-703, Republic of Korea
7Seoul 136-703
8Dankook University
9Department of Nanobiomedical Science
10Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Institute of Tissue Regeneration Engineering (ITREN), Republic of Korea
11Department of Nanobiomedical Science, Dankook University, Cheonan 330-714, Republic of Korea
12Institute of Tissue Regeneration Engineering (ITREN)
13Center for Neuroscience
14Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
15School of Biomedical Engineering,

Tóm tắt

In this paper, we developed a three-dimensional brain-on-a-chip with an interstitial level of flow. The chip contains an osmotic micropump system for providing interstitial flow and a concave microwell array for mimicking the brain's 3D cytoarchitecture.

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Lab on a Chip

Tập 15 Số 1

141-150

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