Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, Ige and IgG<sub>1</sub>, IgG<sub>2a</sub>, IgG<sub>2b</sub>, IgG<sub>2c</sub>

European Journal of Immunology - Tập 4 Số 1 - Trang 44-48 - 1974
Hervé Bazin1,2, Albert Beckers1,3, P. Querinjean4,1
1Department of Experimental Medicine, University of Louvain, Bruxelles
2Staff member of the EURATOM Biology Division, Publication no. 928.
3In receipt of a fellowship from the Caisse Générale d'Epargne et de Retraite (Belgium).
4Chercheur qualifié of the Fonds National de la Recherche Scientifique.

Tóm tắt

AbstractClass or subsclass‐specific differences have been investigated in the monoclonal immunoglobulins produced by 184 secreting immunocytomas raised in the LOU/Wsl inbred strain of rats. Seven classes or subclasses of rat immunoglobulins were detected and the names IgM, IgA, IgE, IgG1, IgG2a, IgG2b and IgG2c proposed for them. The sedimentation coefficients of rat IgG1, IgG2a and IgG2c were found to be respectively, 6.7, 6.4 and 6.7 S. Rat IgG1, IgG2a and IgG2c were found to cross‐react with antisera to human γ‐chains.

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European Journal of Immunology

Tập 4 Số 1

44-48

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