Thiolated polymers: synthesis and in vitro evaluation of polymer–cysteamine conjugates

Bernkop-Schnürch, 1998, Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan–EDTA conjugates, J. Control. Release, 50, 215, 10.1016/S0168-3659(97)00136-3

Bernkop-Schnürch, 1999, Polymers with thiol groups: a new generation of mucoadhesive polymers?, Pharm. Res., 16, 876, 10.1023/A:1018830204170

Bernkop-Schnürch, 1999, Synthese und in vitro evaluierung von chitosan–cystein konjugaten, Sci. Pharm., 67, 197

Bernkop-Schnürch, 2000, Anionic mucoadhesive polymers as auxiliary agents for the peroral administration of (poly)peptide drugs: influence of the gastric fluid, Drug Dev. Ind. Pharm., 26, 107, 10.1081/DDC-100100335

Bernkop-Schnürch, 2000, Synthesis and characterisation of mucoadhesive thiolated polymers, Int. J. Pharm., 194, 239, 10.1016/S0378-5173(99)00387-7

Bernkop-Schnürch, 2000, Polycarbophil–cysteine conjugates as platforms for oral (poly)peptide delivery systems, J. Pharm. Sci., 89, 901, 10.1002/1520-6017(200007)89:7<901::AID-JPS7>3.0.CO;2-0

Bernkop-Schnürch, 2000, Development of controlled drug release systems based on polymer–cysteine conjugates, J. Control. Release, 66, 39, 10.1016/S0168-3659(99)00256-4

Borchard, 1996, Effects of chitosan–glutamate and carbomer on epithelial tight junctions in vitro, J. Control. Release, 39, 131, 10.1016/0168-3659(95)00146-8

Clausen, 2000, In vitro evaluation of the permeation enhancing effect of thiolated polycarbophil, J. Pharm. Sci., 89, 1253, 10.1002/1520-6017(200010)89:10<1253::AID-JPS3>3.0.CO;2-8

Clausen, 2001, Development and in vitro evaluation of a peptide drug delivery system based on thiolated polycarbophil, Pharm. Ind., 63, 312

Clausen, 2001, Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs, Eur. J. Pharm. Biopharm., 51, 25, 10.1016/S0939-6411(00)00130-2

Collares-Buzato, 1998, Increased tyrosine phosphorylation of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia, Eur. J. Cell Biol., 76, 85, 10.1016/S0171-9335(98)80020-4

Delgado, 1999, PLG microparticles stabilised using enteric coating polymers as oral delivery systems, Vaccine, 17, 2927, 10.1016/S0264-410X(99)00140-1

Gum, 1992, The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region, J. Biol. Chem., 267, 21375, 10.1016/S0021-9258(19)36620-7

Junginger, 1999, Recent advances in buccal drug delivery and absorption—in vitro and in vivo studies, J. Control. Release, 62, 149, 10.1016/S0168-3659(99)00032-2

Kast, C.E., Bernkop-Schnürch, A., 2001. Thiolated polymers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates. Biomaterials 22, 2345–2352.

Luessen, 1996, Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo, Pharm Res., 13, 1668, 10.1023/A:1016488623022

Marschütz, 2000, Design and in vivo evaluation of an oral delivery system for insulin, Pharm. Res., 17, 1468, 10.1023/A:1007696723125

Peppas, 1990, Kinetics of mucus–polymer interactions

Sakai, 1997, Effects of absorption enhancer on the transport of model compounds in Caco-2 cell monolayers: assessment by confocal laser scanning microscopy, J. Pharm. Sci., 86, 779, 10.1021/js960529n

Snyder, 1987, Intramolecular disulfide loop formation in a peptide containing two cysteines, Biochemistry, 26, 688, 10.1021/bi00377a005

Snyder, 1981, Electrostatic influence of local cysteine environments on disulfide exchange kinetics, Biochemistry, 20, 6509, 10.1021/bi00526a001

Snyder, 1983, Use of local electrostatic environments of cysteines to enhance formation of a desired species in a reversible disulfide exchange reaction, Biochim. Biophys. Acta, 749, 219, 10.1016/0167-4838(83)90228-5

Staddon, 1995, Evidence that tyrosine phosphorylation may increase tight junction permeability, J. Cell Sci., 108, 609, 10.1242/jcs.108.2.609

Uchiyama, 1998, Effects of various protease inhibitors on the stability and permeability of [d-Ala2, d-Leu5]enkephalin in the rat intestine: comparison with leucine enkephalin, J. Pharm. Sci., 87, 448, 10.1021/js970357+