Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins
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Bernkop-Schnürch, 1999, Polymers with thiol groups: a new generation of mucoadhesive polymers?, Pharm. Res., 16, 876, 10.1023/A:1018830204170
Marschütz, 2002, Thiolated polymers: self-crosslinking properties of thiolated 450kDa polyacrylic acid and their influence on mucoadhesion, Eur. J. Pharm. Sci., 15, 387, 10.1016/S0928-0987(02)00025-8
Kast, 2001, Thiolated polymers – thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates, Biomaterials, 22, 2345, 10.1016/S0142-9612(00)00421-X
A. Krauland, A. Bernkop-Schnürch, Enhanced rheological properties of deacetylated gellan gum by the covalent attachment of cysteine, 11th International Pharmaceutical Technology Symposium, Istanbul (Turkey), 2002, pp. 99–100.
D. Guggi, C.E. Kast, A. Bernkop-Schnürch, In vivo evaluation of an oral calcitonin delivery system based on a thiolated chitosan matrix, 11th International Pharmaceutical Technology Symposium, Istanbul (Turkey), 2002, pp. 41–42.
Bernkop-Schnürch, 2001, Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N, J. Pharm. Sci., 90, 1907, 10.1002/jps.1140
Clausen, 2002, The role of glutathione in the permeation enhancing effect of thiolated polymers, Pharm. Res., 19, 602, 10.1023/A:1015345827091
P. Caliceti, P. Salmaso, C. Lillie, A. Bernkop-Schnürch, Development and in vivo evaluation of an oral insulin–PEG delivery system, 30th Annual Meeting and Exposition of the Controlled Release Society, Glasgow (GB), in press.
Dekker, 2002, The MUC family: an obituary, Trends Biochem. Sci., 27, 126, 10.1016/S0968-0004(01)02052-7
Gum, 1992, The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region, J. Biol. Chem., 267, 21375, 10.1016/S0021-9258(19)36620-7
Bell, 1985, Properties of gastric and duodenal mucus: effect of proteolysis, disulfide reduction, bile acid, ethanol, and hypertonicity on mucus gel structure, Gastroenterology, 88, 269, 10.1016/S0016-5085(85)80180-3
Marshall, 1978, The isolation and characterization of the high-molecular-weight glycoprotein from pig colonic mucus, Biochem. J., 173, 569, 10.1042/bj1730569
Forstner, 1979, The role of disulphide bonds in human intestinal mucin, Biochem. J., 181, 725, 10.1042/bj1810725
Snyder, 1987, Intramolecular disulfide loop formation in a peptide containing two cysteine, Biochemistry, 26, 688, 10.1021/bi00377a005
Munday, 1994, Bioactivation of thiols by one-electron oxidation, Adv. Pharmacol., 27, 237, 10.1016/S1054-3589(08)61035-2
Hassan, 1990, A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength, Pharm. Res., 7, 491, 10.1023/A:1015812615635
Bernkop-Schnürch, 2000, Synthesis and characterisation of mucoadhesive thiolated polymers, Int. J. Pharm., 194, 239, 10.1016/S0378-5173(99)00387-7
Habeeb, 1973, A sensitive method for localization of disulfide containing peptides in column effluents, Anal. Biochem., 56, 60, 10.1016/0003-2697(73)90169-3
Mantle, 1981, Isolation and characterization of the native glycoprotein from pig small-intestinal mucus, Biochem. J., 195, 267, 10.1042/bj1950267
Rossi, 1996, Characterization of mucin interaction with three viscosity grades of sodium carboxymethylcellulose. Comparison between rheological and tensile testing, Eur. J. Pharm. Sci., 4, 189, 10.1016/0928-0987(95)00049-6
Hutton, 1990, Mucolysis of the colonic mucus barrier by faecal proteinases: inhibition by interacting polyacrylate, Clin. Sci., 78, 265, 10.1042/cs0780265
Peppas, 1985, Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J. Control Release, 2, 257, 10.1016/0168-3659(85)90050-1
Chickering, 1999, Definitions, mechanisms, and theories of bioadhesion, 1
Mortazavi, 1995, An in vitro assessment of mucus/mucoadhesive interactions, Int. J. Pharm., 124, 173, 10.1016/0378-5173(95)00073-R
Matthes, 1992, Mucusmodelle zur Untersuchung von intestinalen Absorptionsmechanismen, Pharmazie, 47, 505
Khanvilkar, 2001, Drug transfer through mucus, Adv. Drug Deliv. Rev., 48, 173, 10.1016/S0169-409X(01)00115-6
Fogg, 1996, Characterization of pig colonic mucins, Biochem. J., 181, 725