Thinking While Moving or Moving While Thinking – Concepts of Motor-Cognitive Training for Cognitive Performance Enhancement

Fabian Herold1, Dennis Hamacher2, Lutz Schega2, Notger G. Müller3,4,1
1Research Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
2Department of Sport Science, Institute III, Otto von Guericke University Magdeburg, Magdeburg, Germany
3Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
4Department of Neurology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

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Ahlskog, 2011, Does vigorous exercise have a neuroprotective effect in Parkinson disease?, Neurology, 77, 288, 10.1212/WNL.0b013e318225ab66

Ahn, 2017, Effects of physical exercise on cognition in persons with subjective cognitive decline or mild cognitive impairment: a review., J. Parkinsons Dis. Alzheimers Dis., 4, 1, 10.13188/2376-922X.1000023

Ainsworth, 2000, Compendium of physical activities: an update of activity codes and MET intensities., Med. Sci. Sports Exerc., 32, S498, 10.1097/00005768-200009001-00009

Albert, 1997, The ageing brain: normal and abnormal memory., Philos. Trans. R. Soc. Lond. B Biol. Sci., 352, 1703, 10.1098/rstb.1997.0152

Alves, 2012, Effects of acute physical exercise on executive functions: a comparison between aerobic and strength exercise., J. Sport Exerc. Psychol., 34, 539, 10.1123/jsep.34.4.539

Andersen, 2004, Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia., Health Qual. Life Outcomes, 2, 10.1186/1477-7525-2-52

Assis, 2017, Exercise-dependent BDNF as a modulatory factor for the executive processing of individuals in course of cognitive decline. A systematic review., Front. Psychol., 8, 10.3389/fpsyg.2017.00584

Bamidis, 2014, A review of physical and cognitive interventions in aging., Neurosci. Biobehav. Rev., 44, 206, 10.1016/j.neubiorev.2014.03.019

Barha, 2017, Personalising exercise recommendations for brain health: considerations and future directions., Br. J. Sports Med., 51, 636, 10.1136/bjsports-2016-096710

Batouli, 2017, At least eighty percent of brain grey matter is modifiable by physical activity: a review study., Behav. Brain Res., 332, 204, 10.1016/j.bbr.2017.06.002

Benzing, 2016, Acute cognitively engaging exergame-based physical activity enhances executive functions in adolescents., PLoS One, 11, 10.1371/journal.pone.0167501

Bergami, 2012, A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus., Dev. Neurobiol., 72, 1016, 10.1002/dneu.22025

Bherer, 2013, A review of the effects of physical activity and exercise on cognitive and brain functions in older adults., J. Aging Res., 2013, 10.1155/2013/657508

Blondell, 2014, Does physical activity prevent cognitive decline and dementia? A systematic review and meta-analysis of longitudinal studies., BMC Public Health, 14, 10.1186/1471-2458-14-510

Boissieu, 2017, Exergames and elderly: a non-systematic review of the literature., Eur. Geriatr. Med., 8, 111, 10.1016/j.eurger.2017.02.003

Borror, 2017, Brain-derived neurotrophic factor mediates cognitive improvements following acute exercise., Med. Hypotheses, 106, 1, 10.1016/j.mehy.2017.06.024

Borson, 2010, Cognition, aging, and disabilities: conceptual issues., Phys. Med. Rehabil. Clin. N. Am., 21, 375, 10.1016/j.pmr.2010.01.001

Bostrom, 2009, Cognitive enhancement: methods, ethics, regulatory challenges., Sci. Eng. Ethics, 15, 311, 10.1007/s11948-009-9142-5

Bourdon, 2017, Monitoring athlete training loads: consensus statement., Int. J. Sports Physiol. Perform., 12, S2161, 10.1123/IJSPP.2017-0208

Brigadski, 2014, BDNF: a regulator of learning and memory processes with clinical potential., e-Neuroforum, 5, 1, 10.1007/s13295-014-0053-9

Bruel-Jungerman, 2007, Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses., Rev. Neurosci., 18, 93, 10.1515/REVNEURO.2007.18.2.93

Bruin, 2010, Use of virtual reality technique for the training of motor control in the elderly. Some theoretical considerations., Z. Gerontol. Geriatr., 43, 229, 10.1007/s00391-010-0124-7

Buckner, 2004, Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate., Neuron, 44, 195, 10.1016/j.neuron.2004.09.006

Budde, 2016, The need for differentiating between exercise, physical activity, and training., Autoimmun. Rev., 15, 110, 10.1016/j.autrev.2015.09.004

Budde, 2008, Acute coordinative exercise improves attentional performance in adolescents., Neurosci. Lett., 441, 219, 10.1016/j.neulet.2008.06.024

Buford, 2012, Making preventive medicine more personalized: implications for exercise-related research., Prev. Med., 55, 34, 10.1016/j.ypmed.2012.05.001

Buford, 2013, Toward exercise as personalized medicine., Sports Med., 43, 157, 10.1007/s40279-013-0018-0

Burgess, 2017, The research doesn’t always apply: practical solutions to evidence-based training-load monitoring in elite team sports., Int. J. Sports Physiol. Perform., 12, S2136, 10.1123/ijspp.2016-0608

Cai, 2015, Does exercise impact cognitive performance research article op in community-dwelling older adults with mild cognitive impairment? A systematic review., Qual. Prim. Care, 23, 214

Carlson, 2008, Exploring the effects of an “everyday” activity program on executive function and memory in older adults: experience Corps., Gerontologist, 48, 793, 10.1093/geront/48.6.793

Carvalho, 2014, Physical activity and cognitive function in individuals over 60 years of age: a systematic review., Clin. Interv. Aging, 9, 661, 10.2147/CIA.S55520

Caspersen, 1985, Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research., Public Health Rep., 100, 126

Chaddock-Heyman, 2014, III. The importance of physical activity and aerobic fitness for cognitive control and memory in children., Monogr. Soc. Res. Child Dev., 79, 25, 10.1111/mono.12129

Chang, 2012, The effects of acute exercise on cognitive performance: a meta-analysis., Brain Res., 1453, 87, 10.1016/j.brainres.2012.02.068

Church, 2011, Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity., PLoS One, 6, 10.1371/journal.pone.0019657

Coelho, 2013, Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly., Arch. Gerontol. Geriatr., 56, 10, 10.1016/j.archger.2012.06.003

Colcombe, 2003, Fitness effects on the cognitive function of older adults: a meta-analytic study., Psychol. Sci., 14, 125, 10.1111/1467-9280.t01-1-01430

Colzato, 2016, Editorial., J. Cogn. Enhanc., 1, 1, 10.1007/s41465-016-0001-4

Cotman, 2007, Exercise builds brain health: key roles of growth factor cascades and inflammation., Trends Neurosci., 30, 464, 10.1016/j.tins.2007.06.011

Coubard, 2011, Practice of contemporary dance improves cognitive flexibility in aging., Front. Aging Neurosci., 3, 10.3389/fnagi.2011.00013

Cox, 2016, Relationship between physical activity and cognitive function in apparently healthy young to middle-aged adults: a systematic review., J. Sci. Med. Sport, 19, 616, 10.1016/j.jsams.2015.09.003

Crabbe, 2004, Brain electrocortical activity during and after exercise: a quantitative synthesis., Psychophysiology, 41, 563, 10.1111/j.1469-8986.2004.00176.x

Crum, 2007, Mind-set matters: exercise and the placebo effect., Psychol. Sci., 18, 165, 10.1111/j.1467-9280.2007.01867.x

Dahlin, 2008, Transfer of learning after updating training mediated by the striatum., Science, 320, 1510, 10.1126/science.1155466

Dhami, 2014, New framework for rehabilitation - fusion of cognitive and physical rehabilitation: the hope for dancing., Front. Psychol., 5, 10.3389/fpsyg.2014.01478

Dinoff, 2017, The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis., Eur. J. Neurosci., 46, 1635, 10.1111/ejn.13603

Erickson, 2013, Physical activity and brain plasticity in late adulthood., Dialogues Clin. Neurosci., 15, 99, 10.31887/DCNS.2013.15.1/kerickson

Erickson, 2011, Exercise training increases size of hippocampus and improves memory., Proc. Natl. Acad. Sci. U.S.A., 108, 3017, 10.1073/pnas.1015950108

Esteban-Cornejo, 2015, Physical activity and cognition in adolescents: a systematic review., J. Sci. Med. Sport, 18, 534, 10.1016/j.jsams.2014.07.007

Fabel, 2009, Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice., Front. Neurosci., 3, 10.3389/neuro.22.002.2009

Falck, 2016, What is the association between sedentary behaviour and cognitive function? A systematic review., Br. J. Sports Med., 51, 800, 10.1136/bjsports-2015-095551

Fiest, 2016, The prevalence and incidence of dementia: a systematic review and meta-analysis., Can. J. Neurol. Sci., S3, 10.1017/cjn.2016.18

Fissler, 2013, Novelty interventions to enhance broad cognitive abilities and prevent dementia: synergistic approaches for the facilitation of positive plastic change., Prog. Brain Res., 207, 403, 10.1016/B978-0-444-63327-9.00017-5

Fjell, 2010, Structural brain changes in aging: courses, causes and cognitive consequences., Rev. Neurosci., 21, 187, 10.1515/REVNEURO.2010.21.3.187

Frith, 2017, Randomized controlled trial evaluating the temporal effects of high-intensity exercise on learning, short-term and long-term memory, and prospective memory., Eur. J. Neurosci., 46, 2557, 10.1111/ejn.13719

Geibig, 2012, Functional recruitment of newborn hippocampal neurons after experimental stroke., Neurobiol. Dis., 46, 431, 10.1016/j.nbd.2012.02.007

Greeff, 2017, Effects of physical activity on executive functions, attention and academic performance in preadolescent children: a meta-analysis., J. Sci. Med. Sport, 21, 501, 10.1016/j.jsams.2017.09.595

Green, 2012, Learning, attentional control, and action video games., Curr. Biol., 22, R197, 10.1016/j.cub.2012.02.012

Groot, 2016, The effect of physical activity on cognitive function in patients with dementia: a meta-analysis of randomized control trials., Ageing Res. Rev., 25, 13, 10.1016/j.arr.2015.11.005

Hamacher, 2017, Motor-cognitive dual-tasking under hypoxia., Exp. Brain Res., 235, 2997, 10.1007/s00221-017-5036-y

Hamacher, , The effect of a six-month dancing program on motor-cognitive dual-task performance in older adults., JAPA, 23, 647, 10.1123/japa.2014-0067

Hamacher, , Motor-cognitive dual-task training improves local dynamic stability of normal walking in older individuals., Clin. Biomech., 32, 138, 10.1016/j.clinbiomech.2015.11.021

Hamacher, 2016, The reliability of local dynamic stability in walking while texting and performing an arithmetical problem., Gait Posture, 44, 200, 10.1016/j.gaitpost.2015.12.021

Hamacher, , Brain activity during walking: a systematic review., Neurosci. Biobehav. Rev., 57, 310, 10.1016/j.neubiorev.2015.08.002

Hashimoto, 2015, Effects of dance on motor functions, cognitive functions, and mental symptoms of Parkinson’s disease: a quasi-randomized pilot trial., Complement. Ther. Med, 23, 210, 10.1016/j.ctim.2015.01.010

Hedden, 2004, Insights into the ageing mind: a view from cognitive neuroscience., Nat. Rev. Neurosci., 5, 87, 10.1038/nrn1323

Helfer, 2015, Affect and exercise: positive affective expectations can increase post-exercise mood and exercise intentions., Ann. Behav. Med., 49, 269, 10.1007/s12160-014-9656-1

Heyn, 2004, The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated., Arch. Phys. Med. Rehabil., 85, 1694, 10.1016/j.apmr.2004.03.019

Hillman, 2008, Be smart, exercise your heart: exercise effects on brain and cognition., Nat. Rev. Neurosci., 9, 58, 10.1038/nrn2298

Hillman, 2013, Der Zusammenhang von Fitness, kognitiver Leistungsfähigkeit und Gehirnzustand im Schulkindalter., Z. Sportpsychol., 20, 33, 10.1026/1612-5010/a000085

Hofmann, 2010, Special needs to prescribe exercise intensity for scientific studies., Cardiol. Res. Pract., 2011, 10.4061/2011/209302

Hötting, 2013, Beneficial effects of physical exercise on neuroplasticity and cognition., Neurosci. Biobehav. Rev., 37, 2243, 10.1016/j.neubiorev.2013.04.005

Howley, 2001, Type of activity: resistance, aerobic and leisure versus occupational physical activity., Med. Sci. Sports Exerc., 33, S364, 10.1097/00005768-200106001-00005

Hurd, 2013, Monetary costs of dementia in the United States., N. Engl. J. Med., 368, 1326, 10.1056/NEJMsa1204629

Janssen, 2012, Health care costs of physical inactivity in Canadian adults., Appl. Physiol. Nutr. Metab., 37, 803, 10.1139/h2012-061

Jobe, 2001, Active: a cognitive intervention trial to promote independence in older adults., Control. Clin. Trials, 22, 453, 10.1016/S0197-2456(01)00139-8

Kasai, 2003, Structure–stability–function relationships of dendritic spines., Trends Neurosci., 26, 360, 10.1016/S0166-2236(03)00162-0

Kempermann, 2010, Why and how physical activity promotes experience-induced brain plasticity., Front. Neurosci., 4, 10.3389/fnins.2010.00189

Khan, 2014, The relation of childhood physical activity and aerobic fitness to brain function and cognition: a review., Pediatr. Exerc. Sci., 26, 138, 10.1123/pes.2013-0125

Knaepen, 2010, Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects., Sports Med., 40, 765, 10.2165/11534530-000000000-00000

Koleske, 2013, Molecular mechanisms of dendrite stability., Nat. Rev. Neurosci., 14, 536, 10.1038/nrn3486

Koutsandreou, 2016, Effects of motor versus cardiovascular exercise training on children’s working memory., Med. Sci. Sports Exerc., 48, 1144, 10.1249/MSS.0000000000000869

Kraft, 2012, Cognitive function, physical activity, and aging: possible biological links and implications for multimodal interventions., Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn., 19, 248, 10.1080/13825585.2011.645010

Ku, 2017, Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: two-year follow-up study in community-dwelling older adults., Exp. Gerontol., 99, 110, 10.1016/j.exger.2017.09.014

Lague-Beauvais, 2015, Shedding light on the effect of priority instructions during dual-task performance in younger and older adults: a fNIRS study., Brain Cogn., 98, 1, 10.1016/j.bandc.2015.05.001

Lauenroth, 2016, Influence of combined physical and cognitive training on cognition: a systematic review., BMC Geriatr., 16, 10.1186/s12877-016-0315-1

Lautenschlager, 2013, Can participation in mental and physical activity protect cognition in old age? Comment on “The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults”., JAMA Intern. Med., 173, 805, 10.1001/jamainternmed.2013.206

Levin, 2017, The beneficial effects of different types of exercise interventions on motor and cognitive functions in older age: a systematic review., Eur. Rev. Aging Phys. Act., 14, 10.1186/s11556-017-0189-z

Li, 2017, The effect of acute and chronic exercise on cognitive function and academic performance in adolescents: a systematic review., J. Sci. Med. Sport, 20, 841, 10.1016/j.jsams.2016.11.025

Lu, 2013, BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases., Nat. Rev. Neurosci., 14, 401, 10.1038/nrn3505

Ludyga, 2016, Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: a meta-analysis., Psychophysiology, 53, 1611, 10.1111/psyp.12736

Lustig, 2009, Aging, training, and the brain: a review and future directions., Neuropsychol. Rev., 19, 504, 10.1007/s11065-009-9119-9

Mann, 2013, Methods of prescribing relative exercise intensity: physiological and practical considerations., Sports Med., 43, 613, 10.1007/s40279-013-0045-x

Mansoubi, 2015, Energy expenditure during common sitting and standing tasks: examining the 1.5 MET definition of sedentary behaviour., BMC Public Health, 15, 10.1186/s12889-015-1851-x

Marchetti, 2015, Physical and motor fitness, sport skills and executive function in adolescents: a moderated prediction model., Psychology, 6, 1915, 10.4236/psych.2015.614189

Mavilidi, 2018, Immediate and delayed effects of integrating physical activity into preschool children’s learning of numeracy skills., J. Exp. Child Psychol., 166, 502, 10.1016/j.jecp.2017.09.009

Mavilidi, 2016, Infusing physical activities into the classroom: effects on preschool children’s geography learning., Mind Brain Educ., 10, 256, 10.1111/mbe.12131

Mavilidi, 2017, Effects of integrating physical activities into a science lesson on preschool children’s learning and enjoyment., Appl. Cogn. Psychol., 31, 281, 10.1002/acp.3325

Meyer, 1999, Is determination of exercise intensities as percentages of VO2max or HRmax adequate?, Med. Sci. Sports Exerc., 31, 1342, 10.1097/00005768-199909000-00017

Monteiro-Junior, 2016, Exergames: neuroplastic hypothesis about cognitive improvement and biological effects on physical function of institutionalized older persons., Neural Regen. Res., 11, 201, 10.4103/1673-5374.177709

Moreau, 2015, Brains and brawn: complex motor activities to maximize cognitive enhancement., Educ. Psychol. Rev., 27, 475, 10.1007/s10648-015-9323-5

Moreau, 2013, Cognitive enhancement: a comparative review of computerized and athletic training programs., Int. Rev. Sport Exerc. Psychol., 6, 155, 10.1080/1750984X.2012.758763

Mothes, 2016, Expectations affect psychological and neurophysiological benefits even after a single bout of exercise., J. Behav. Med., 40, 293, 10.1007/s10865-016-9781-3

Müller, 2016, Effekte eines Tanz- und eines Gesundheitssporttrainings auf die graue Hirnsubstanz gesunder Senioren., Sportwissenschaft, 46, 213, 10.1007/s12662-016-0411-6

Müller, 2017, Evolution of neuroplasticity in response to physical activity in old age: the case for dancing., Front. Aging Neurosci., 9, 10.3389/fnagi.2017.00056

Nithianantharajah, 2009, The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders., Prog. Neurobiol., 89, 369, 10.1016/j.pneurobio.2009.10.001

Northey, 2017, Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis., Br. J. Sports Med., 52, 154, 10.1136/bjsports-2016-096587

Owen, 2010, Sedentary behavior: emerging evidence for a new health risk., Mayo Clin. Proc., 85, 1138, 10.4065/mcp.2010.0444

Paas, 2003, Cognitive load theory and instructional design: recent developments., Educ. Psychol., 38, 1, 10.1207/S15326985EP3801_1

Paas, 2012, An evolutionary upgrade of cognitive load theory: using the human motor system and collaboration to support the learning of complex cognitive tasks., Educ. Psychol. Rev., 24, 27, 10.1007/s10648-011-9179-2

Paillard, 2015, Preventive effects of regular physical exercise against cognitive decline and the risk of dementia with age advancement., Sports Med. Open, 1, 10.1186/s40798-015-0016-x

Pal, 2016, Study of visuospatial skill in patients with dementia., Ann. Indian Acad. Neurol., 19, 83, 10.4103/0972-2327.168636

Park, 2002, Models of visuospatial and verbal memory across the adult life span., Psychol. Aging, 17, 299, 10.1037/0882-7974.17.2.299

Peeters, 2014, Health care costs associated with prolonged sitting and inactivity., Am. J. Prev. Med., 46, 265, 10.1016/j.amepre.2013.11.014

Pesce, 2012, Shifting the focus from quantitative to qualitative exercise characteristics in exercise and cognition research., J. Sport Exerc. Psychol., 34, 766, 10.1123/jsep.34.6.766

Pichierri, 2012, A cognitive-motor intervention using a dance video game to enhance foot placement accuracy and gait under dual task conditions in older adults: a randomized controlled trial., BMC Geriatr., 12, 10.1186/1471-2318-12-74

Piepmeier, 2015, Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance., J. Sport Health Sci., 4, 14, 10.1016/j.jshs.2014.11.001

Plummer, , Texting and walking: effect of environmental setting and task prioritization on dual-task interference in healthy young adults., Gait Posture, 41, 46, 10.1016/j.gaitpost.2014.08.007

Plummer, 2015, Measuring treatment effects on dual-task performance: a framework for research and clinical practice., Front. Hum. Neurosci., 9, 10.3389/fnhum.2015.00225

Plummer, 2013, Cognitive-motor interference during functional mobility after stroke: state of the science and implications for future research., Arch. Phys. Med. Rehabil., 94, 2565, 10.1016/j.apmr.2013.08.002

Plummer, , Instructions and skill level influence reliability of dual-task performance in young adults., Gait Posture, 41, 964, 10.1016/j.gaitpost.2015.03.348

Plummer, 2014, Feasibility of dual-task gait training for community-dwelling adults after stroke: a case series., Stroke Res. Treat., 2014, 10.1155/2014/538602

Pontifex, 2009, The effect of acute aerobic and resistance exercise on working memory., Med. Sci. Sports Exerc., 41, 927, 10.1249/MSS.0b013e3181907d69

Pouw, , Toward a more embedded/extended perspective on the cognitive function of gestures., Front. Psychol., 5, 10.3389/fpsyg.2014.00359

Pouw, , An embedded and embodied cognition review of instructional manipulatives., Educ. Psychol. Rev., 26, 51, 10.1007/s10648-014-9255-5

Prince, 2013, The global prevalence of dementia: a systematic review and metaanalysis., Alzheimers Dement., 9, 10.1016/j.jalz.2012.11.007

Raichlen, 2017, Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health., Trends Neurosci., 40, 408, 10.1016/j.tins.2017.05.001

Rehfeld, 2017, Dancing or fitness sport? The effects of two training programs on hippocampal plasticity and balance abilities in healthy seniors., Front. Hum. Neurosci., 11, 10.3389/fnhum.2017.00305

Roig, 2013, The effects of cardiovascular exercise on human memory: a review with meta-analysis., Neurosci. Biobehav. Rev., 37, 1645, 10.1016/j.neubiorev.2013.06.012

Roig, 2012, A single bout of exercise improves motor memory., PLoS One, 7, 10.1371/journal.pone.0044594

Rolland, 2010, Healthy brain aging: role of exercise and physical activity., Clin. Geriatr. Med., 26, 75, 10.1016/j.cger.2009.11.002

Ruiter, 2015, Watch your step children! learning two-digit numbers through mirror-based observation of self-initiated body movements., Educ. Psychol. Rev., 27, 457, 10.1007/s10648-015-9324-4

Scharhag-Rosenberger, 2010, Exercise at given percentages of VO2max: heterogeneous metabolic responses between individuals., J. Sci. Med. Sport, 13, 74, 10.1016/j.jsams.2008.12.626

Scherder, 2011, Understanding higher level gait disturbances in mild dementia in order to improve rehabilitation: ‘Last in–first out’., Neurosci. Biobehav. Rev., 35, 699, 10.1016/j.neubiorev.2010.08.009

Scherder, 2010, The more physical inactivity, the more agitation in dementia., Int. Psychogeriatr., 22, 1203, 10.1017/S1041610210001493

Schlaffke, 2014, Sports and brain morphology - a voxel-based morphometry study with endurance athletes and martial artists., Neuroscience, 259, 35, 10.1016/j.neuroscience.2013.11.046

Schneider, 2009, Changes in brain cortical activity measured by EEG are related to individual exercise preferences., Physiol. Behav., 98, 447, 10.1016/j.physbeh.2009.07.010

Schott, 2015, Trail Walking Test zur Erfassung der motorisch-kognitiven Interferenz bei alteren Erwachsenen. Entwicklung und Uberprufung der psychometrischen Eigenschaften des Verfahrens., Z. Gerontol. Geriatr., 48, 722, 10.1007/s00391-015-0866-3

Shams, 2008, Benefits of multisensory learning., Trends Cogn. Sci., 12, 411, 10.1016/j.tics.2008.07.006

Skjæret, 2016, Exercise and rehabilitation delivered through exergames in older adults: an integrative review of technologies, safety and efficacy., Int. J. Med. Inf., 85, 1, 10.1016/j.ijmedinf.2015.10.008

Smith, 2013, Physical activity and brain function in older adults at increased risk for Alzheimer’s disease., Brain Sci., 3, 54, 10.3390/brainsci3010054

Sofi, 2011, Physical activity and risk of cognitive decline: a meta-analysis of prospective studies., J. Intern. Med., 269, 107, 10.1111/j.1365-2796.2010.02281.x

Song, 2018, The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis., Int. J. Nurs. Stud., 79, 155, 10.1016/j.ijnurstu.2018.01.002

Stern, 2002, What is cognitive reserve? Theory and research application of the reserve concept., J. Int. Neuropsychol. Soc., 8, 448, 10.1017/S1355617702813248

Stern, 2009, Cognitive reserve., Neuropsychologia, 47, 2015, 10.1016/j.neuropsychologia.2009.03.004

Stern, 2012, Cognitive reserve in ageing and Alzheimer’s disease., Lancet Neurol., 11, 1006, 10.1016/S1474-4422(12)70191-6

Stern, 2013, Cognitive reserve: implications for assessment and intervention., Folia Phoniatr. Logop., 65, 49, 10.1159/000353443

Stillman, 2016, Mediators of physical activity on neurocognitive function: a review at multiple levels of analysis., Front. Hum. Neurosci., 10, 10.3389/fnhum.2016.00626

Stimpson, 2018, Joggin’ the noggin: towards a physiological understanding of exercise-induced cognitive benefits., Neurosci. Biobehav. Rev., 88, 177, 10.1016/j.neubiorev.2018.03.018

Szuhany, 2015, A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor., J. Psychiatr. Res., 60, 56, 10.1016/j.jpsychires.2014.10.003

Tait, 2017, Influence of sequential vs. simultaneous dual-task exercise training on cognitive function in older adults., Front. Aging Neurosci., 9, 10.3389/fnagi.2017.00368

Tarr, 2002, Virtual reality in behavioral neuroscience and beyond., Nat. Neurosci., 5, 1089, 10.1038/nn948

Toumpaniari, 2015, Preschool children’s foreign language vocabulary learning by embodying words through physical activity and gesturing., Educ. Psychol. Rev., 27, 445, 10.1007/s10648-015-9316-4

Trachtenberg, 2002, Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex., Nature, 420, 788, 10.1038/nature01273

Trombly, 1995, Occupation: purposefulness and meaningfulness as therapeutic mechanisms. 1995 Eleanor Clarke Slagle Lecture., Am. J. Occup. Ther., 49, 960, 10.5014/ajot.49.10.960

van Dongen, 2016, Physical exercise performed four hours after learning improves memory retention and increases hippocampal pattern similarity during retrieval., Curr. Biol., 26, 1722, 10.1016/j.cub.2016.04.071

Vanrenterghem, 2017, Training load monitoring in team sports: a novel framework separating physiological and biomechanical load-adaptation pathways., Sports Med., 47, 2135, 10.1007/s40279-017-0714-2

Verburgh, 2014, Physical exercise and executive functions in preadolescent children, adolescents and young adults: a meta-analysis., Br. J. Sports Med., 48, 973, 10.1136/bjsports-2012-091441

Verghese, 2003, Leisure activities and the risk of dementia in the elderly., N. Engl. J. Med., 348, 2508, 10.1056/NEJMoa022252

Voelcker-Rehage, 2010, Physical and motor fitness are both related to cognition in old age., Eur. J. Neurosci., 31, 167, 10.1111/j.1460-9568.2009.07014.x

Voelcker-Rehage, 2011, Cardiovascular and coordination training differentially improve cognitive performance and neural processing in older adults., Front. Hum. Neurosci., 5, 10.3389/fnhum.2011.00026

Voelcker-Rehage, 2013, Structural and functional brain changes related to different types of physical activity across the life span., Neurosci. Biobehav. Rev., 37, 2268, 10.1016/j.neubiorev.2013.01.028

Wilson, 2002, Six views of embodied cognition., Psychon. Bull. Rev., 9, 625, 10.3758/BF03196322

Wimo, 2013, The worldwide economic impact of dementia 2010., Alzheimers Dement., 9, 10.1016/j.jalz.2012.11.006

Yogev-Seligmann, , Do we always prioritize balance when walking? Towards an integrated model of task prioritization., Mov. Disord., 27, 765, 10.1002/mds.24963

Yogev-Seligmann, , Effects of explicit prioritization on dual task walking in patients with Parkinson’s disease., Gait Posture, 35, 641, 10.1016/j.gaitpost.2011.12.016

Zach, 2016, The influence of acute physical activity on working memory., Percept. Mot. Skills, 122, 365, 10.1177/0031512516631066

Zelinski, 2009, Far transfer in cognitive training of older adults., Restor. Neurol. Neurosci., 27, 455, 10.3233/RNN-2009-0495