Thick fetal corpus callosum: an ominous sign?

Wiley - Tập 34 Số 1 - Trang 55-61 - 2009
Tally Lerman‐Sagie1,2,3, Liat Ben‐Sira4,3, R. Achiron5,3, Letizia Schreiber6,3, Gratiana Hermann7,3, Dorit Lev1,8,3, Dvora Kidron9,3, G. Malinger10,1,3
1Fetal Neurology Clinic, Wolfson Medical Center, Holon, Israel
2Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel
3Affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
4Pediatric Radiology Unit, Sourasky Medical Center, Tel-Aviv, Israel
5Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel
6Department of Pathology, Wolfson Medical Center, Holon, Israel
7Department of Pathology, Assaf Harofe Medical Center, Tzrifin, Israel
8Genetics Institute, Wolfson Medical Center, Holon, Israel
9Department of Pathology, Sapir Medical Center, Kfar-Saba, Israel
10Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel

Tóm tắt

AbstractObjectiveAnomalies of the corpus callosum are frequently diagnosed during pregnancy, but a thick corpus callosum is a rare finding and its significance is not clear. We aimed to assess the significance of thick fetal corpus callosum by reviewing our experience of such cases.MethodsThe records of all fetuses with anomalies of the corpus callosum referred to the prenatal diagnosis units of two university hospitals from 2000 to 2007 were reviewed. Nine fetuses with a thick corpus callosum were identified.ResultsIn all cases there were associated abnormalities: macrocephaly, ventriculomegaly, vermian agenesis, abnormal sulcation or encephalocele. Four pregnancies were terminated and in each of these cases the autopsy confirmed dysmorphic features and additional brain abnormalities. Five infants were delivered; two died shortly after birth, one suffers from mental retardation, one had neonatal convulsions and one is developing normally.ConclusionsA thick fetal corpus callosum is usually associated with other brain anomalies and is part of a neurogenetic syndrome in most cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.

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Wiley

Tập 34 Số 1

55-61

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