Therapeutic response of patients with adult Still’s disease to biologic agents: multicenter results in Japan

Oxford University Press (OUP) - Tập 22 - Trang 712-719 - 2011
Rie Suematsu1, Akihide Ohta2, Emi Matsuura3, Hiroki Takahashi4, Takao Fujii5, Takahiko Horiuchi6, Seiji Minota7, Yoshiaki Ishigatsubo8, Toshiyuki Ota9, Shuji Takei10, Sachiko Soejima1, Hisako Inoue1, Syuichi Koarada1, Yoshifumi Tada1, Kohei Nagasawa1
1Division of Rheumatology, Department of Internal Medicine, Saga University School of Medicine, Saga, Japan
2Department of Adult and Gerontological Nursing, Saga University School of Medicine, Saga, Japan
3Faculty of Nursing, Kwassui Women’s University, Nagasaki, Japan
41st Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
5Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
6Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
7Division of Rheumatology/Clinical Immunology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
8Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
9Department of Laboratory and Transfusion Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
10School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

Tóm tắt

The efficacy of biologics in treating adult Still’s disease (ASD) is suggested, but the information is still lacking and the validation is insufficient. To determine the efficacy of several biologic agents in refractory ASD in Japan, a multicenter survey was performed. Clinical data on 16 ASD patients who had been treated with at least 1 of the biological agents (total 24 occasions) were collected retrospectively. Infliximab was used in 9 cases, etanercept in 4, and tocilizumab in 11. Half of the patients that had been treated initially with infliximab or etanercept were changed to another biologics. Tocilizumab was effective in cases switched from another 2 drugs. Tocilizumab showed efficacy in treating both systemic and arthritic symptoms and showed apparent steroid-sparing effect and the highest continuation rate. Tocilizumab may be a promising biologic agent in refractory ASD.

Tài liệu tham khảo

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