Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units

Floyer J. An essay to restore the dipping of infants in their baptism; with a dialogue betwixt a curate and a practitioner, concerning the manner of immersion. London: Holland. 1722. 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Part 7: neonatal resuscitation. Resuscitation 2005; 67(2–3):293–303. Gunn, 1997, Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs, J Clin Invest, 99, 248, 10.1172/JCI119153 Laptook, 1997, Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia, Pediatr Res, 42, 17, 10.1203/00006450-199707000-00004 Thoresen, 1996, Posthypoxic cooling of neonatal rats provides protection against brain injury, Arch Dis Child Fetal Neonatal Ed, 74, F3, 10.1136/fn.74.1.F3 Bernard, 2002, Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia, N Engl J Med, 346, 557, 10.1056/NEJMoa003289 Gluckman, 2005, Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial, Lancet, 365, 663, 10.1016/S0140-6736(05)17946-X Eicher, 2005, Moderate hypothermia in neonatal encephalopathy: efficacy outcomes, Pediatr Neurol, 32, 11, 10.1016/j.pediatrneurol.2004.06.014 Thoresen, 2000, Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy, Pediatrics, 106, 92, 10.1542/peds.106.1.92 Shankaran, 2005, Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy, N Engl J Med, 353, 1574, 10.1056/NEJMcps050929 Eicher, 2005, Moderate hypothermia in neonatal encephalopathy: safety outcomes, Pediatr Neurol, 32, 18, 10.1016/j.pediatrneurol.2004.06.015 Blackmon, 2006, Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy, Pediatrics, 117, 942, 10.1542/peds.2005-2950 Higgins, 2006, Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop, J Pediatr, 148, 170, 10.1016/j.jpeds.2005.12.009 Edwards, 2006, Therapeutic hypothermia following perinatal asphyxia, Arch Dis Child Fetal Neonatal Ed, 91, F127, 10.1136/adc.2005.071787 Schulzke, 2007, A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy – are we there yet?, BMC Pediatrics, 7, 30, 10.1186/1471-2431-7-30 Shah, 2007, Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review, Arch Pediatr Adolesc Med, 161, 951, 10.1001/archpedi.161.10.951 Jacobs, 2007, Cooling for newborns with hypoxic ischaemic encephalopathy, Cochrane Database Syst Rev, CD003311 Rutherford, 2005, Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy, Pediatrics, 116, 1001, 10.1542/peds.2005-0328 Gunn, 2006, Hypothermic neuroprotection, NeuroRx, 3, 154, 10.1016/j.nurx.2006.01.007 Tooley, 2002, Significant selective head cooling can be maintained long-term after global hypoxia ischemia in newborn piglets, Pediatrics, 109, 643, 10.1542/peds.109.4.643 Compagnoni, 2007, Safety of deep hypothermia in treating neonatal asphyxia, Neonatology, 93, 230, 10.1159/000111101 Inder, 2004, Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy, J Pediatr, 145, 835, 10.1016/j.jpeds.2004.07.034 Wyatt, 2007, Determinants of outcomes after head cooling for neonatal encephalopathy, Pediatrics, 119, 912, 10.1542/peds.2006-2839 Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346(8):549–56. Lang, 2007, Hypothermia for the treatment of neonatal ischemic encephalopathy: is the genie out of the bottle?, Am J Perinatol, 24, 27, 10.1055/s-2006-958157 Gunn, 1998, Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep, Pediatrics, 102, 1098, 10.1542/peds.102.5.1098 Suehiro, 2001, Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin A, J Neurosurg, 94, 493, 10.3171/jns.2001.94.3.0493 Horan, 2007, Lack of influence of mild hypothermia on amplitude integrated-electroencephalography in neonates receiving extracorporeal membrane oxygenation, Early Hum Dev, 83, 69, 10.1016/j.earlhumdev.2006.05.004 Anderson, 2007, Passive cooling to initiate hypothermia for transported encephalopathic newborns, J Perinatol, 27, 592, 10.1038/sj.jp.7211781