Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma

Philip, 2001, Osteosarcoma, Br. J. Cancer, 84, 78, 10.1054/bjoc.2000.1770 Van Glabbeke, 2005, J. Clin. Oncol., 17, 150, 10.1200/JCO.1999.17.1.150 Clark, 1999, Soft-tissue sarcomas in adults, N. Engl. J. Med., 353, 701, 10.1056/NEJMra041866 Kurtz, 1995, Pleiotrophin and midkine in normal development and tumor biology, Crit. Rev. Oncog., 6, 151 Kadomatsu, 1988, cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis, Biochem. Biophys. Res. Commun., 151, 1312, 10.1016/S0006-291X(88)80505-9 Muramatsu, 2002, Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis, J. Biochem., 132, 359, 10.1093/oxfordjournals.jbchem.a003231 Muramatsu, 1993, Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution, Dev. Biol., 159, 392, 10.1006/dbio.1993.1250 Owada, 1999, Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons, J. Neurochem., 73, 2084 Maeda, 1999, A receptor-like protein-tyrosine phosphatase PTPζ/RPTPβ binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPζ, J. Biol. Chem., 274, 12474, 10.1074/jbc.274.18.12474 Sato, 2001, Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury, J. Immunol., 167, 3463, 10.4049/jimmunol.167.6.3463 Muramatsu, 2006, Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors, Genes Cells, 11, 1405, 10.1111/j.1365-2443.2006.01028.x Yoshida, 2001, Intraventricular administration of the neurotrophic factor midkine ameliorates hippocampal delayed neuronal death following transient forebrain ischemia in gerbils, Brain Res., 894, 46, 10.1016/S0006-8993(00)03209-1 Garver, 1993, Reciprocal expression of pleiotrophin and midkine in normal vs malignant lung tissues, Am. J. Respir. Cell. Mol. Biol., 9, 463, 10.1165/ajrcmb/9.5.463 Garver, 1994, Midkine and pleiotrophin expression in normal and malignant breast tissue, Cancer, 74, 1584, 10.1002/1097-0142(19940901)74:5<1584::AID-CNCR2820740514>3.0.CO;2-V Konishi, 1999, Immunohistochemical analysis of midkine expression in human prostate carcinoma, Oncology, 57, 253, 10.1159/000012039 Ye, 1999, Expression of midkine in the early stage of carcinogenesis in human colorectal cancer, Br. J. Cancer, 79, 179, 10.1038/sj.bjc.6690030 Ota, 2008, Midkine as a prognostic biomarker in oral squamous cell carcinoma, Br. J. Cancer, 99, 655, 10.1038/sj.bjc.6604539 Ibusuki, 2009, Midkine in plasma as a novel breast cancer marker, Cancer Sci., 100, 1735, 10.1111/j.1349-7006.2009.01233.x Jin, 2008, Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target, Clin. Cancer Res., 14, 5033, 10.1158/1078-0432.CCR-08-0092 Maehara, 2007, Midkine as a novel target therapy in osteosarcoma, Biochem. Biophys. Res. Commun., 358, 757, 10.1016/j.bbrc.2007.04.183 Adachi, 2001, A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging, Cancer Res., 61, 7882 Luu, 2005, An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis, Clin. Exp. Metastasis, 22, 319, 10.1007/s10585-005-0365-9 Shinriki, 2009, Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma, Clin. Cancer Res., 15, 5426, 10.1158/1078-0432.CCR-09-0287 Michelle, 2002, Inhibition of protein kinase B/Akt: implications for cancer therapy, Pharmacol. Ther., 93, 243, 10.1016/S0163-7258(02)00193-6 Chen, 2008, Involvement of PI3K/AKT/GSK3β pathway in tetrandrine-induced G1 arrest and apoptosis, Cancer Biol. Ther., 7, 1073, 10.4161/cbt.7.7.6142 Sandra, 2004, Midkine induced growth of ameloblastoma through MAPK and Akt pathways, Oral Oncol., 40, 274, 10.1016/j.oraloncology.2003.08.011 Shor, 2007, Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on Src kinase for survival, Cancer Res., 67, 2800, 10.1158/0008-5472.CAN-06-3469 Muramatsu, 2010, Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases, Proc. Jpn. Acad. Ser. B: Phys. Biol. Sci., 86, 410, 10.2183/pjab.86.410 Hwang, 2005, Cyclin E in normal and neoplastic cell cycles, Oncogene, 24, 2776, 10.1038/sj.onc.1208613 Swanton, 2004, Cell-cycle targeted therapies, Lancet Oncol., 5, 27, 10.1016/S1470-2045(03)01321-4 Steinman, 1994, Induction of p21 (WAF-1/CIP1) during differentiation, Oncogene, 9, 3389 Eastman, 2004, Cell cycle checkpoints and their impact on anticancer therapeutic strategies, J. Cell Biochem., 91, 223, 10.1002/jcb.10699 Gartel, 1996, p21—negative regulator of the cell cycle, Proc. Soc. Exp. Biol. Med., 213, 138, 10.3181/00379727-213-44046 Takada, 1997, Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis, J. Biochem., 122, 453, 10.1093/oxfordjournals.jbchem.a021773 Choudhuri, 1997, An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis, Cancer Res., 57, 1814 Sumi, 2002, Midkine, a heparin-binding growth factor, promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model, J. Cell Sci., 115, 2659, 10.1242/jcs.115.13.2659 Krzystek-Korpacka, 2007, Serum midkine depends on lymph node involvement and correlates with circulating VEGF-C in oesophageal squamous cell carcinoma, Biomarkers, 12, 403, 10.1080/13547500701192470 Ikematsu, 2000, Serum midkine levels are increased in patients with various types of carcinomas, Br. J. Cancer, 83, 701, 10.1054/bjoc.2000.1339 Muramatsu, 1996, Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas, J. Biochem., 119, 1171, 10.1093/oxfordjournals.jbchem.a021364 Obata, 2005, Serum midkine concentrations and gastric cancer, Cancer Sci., 96, 54, 10.1111/j.1349-7006.2005.00001.x