Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation

Afshar, 2013, Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases, J Eur Acad Dermatol Venereol, 27, 771, 10.1111/j.1468-3083.2012.04582.x

Baechler, 2006, Gene expression profiling in human autoimmunity, Immunol Rev, 210, 120, 10.1111/j.0105-2896.2006.00367.x

Bhattacharya, 2013, Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses, Oncogene, 32, 4214, 10.1038/onc.2012.439

Bhattacharya, 2010, Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor, J Biol Chem, 285, 2318, 10.1074/jbc.M109.071498

Bhattacharya, 2014, Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury, EMBO Mol Med, 6, 384, 10.1002/emmm.201303236

Bhattacharya, 2011, Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor, J Biol Chem, 286, 22069, 10.1074/jbc.M111.238766

Bissonnette, 2010, A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis, J Am Acad Dermatol, 62, 427, 10.1016/j.jaad.2009.05.042

Chen, 2014, UV signaling pathways within the skin, J Invest Dermatol, 134, 2080, 10.1038/jid.2014.161

Coccia, 2006, Negative regulation of type I interferon signaling: facts and mechanisms, Cell Mol Biol (Noisy-le-grand), 52, 77

Deng, 2002, Activation of GCN2 in UV-irradiated cells inhibits translation, Curr Biol, 12, 1279, 10.1016/S0960-9822(02)01037-0

Fuchs, 2013, Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy, Interferon Cytokine Res, 33, 211, 10.1089/jir.2012.0117

Goldman, 1999, Characterization of antihuman IFNAR-1 monoclonal antibodies: epitope localization and functional analysis, J Interferon Cytokine Res, 19, 15, 10.1089/107999099314379

Grine, 2015, Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice, J Immunol, 194, 5094, 10.4049/jimmunol.1403015

Hazzalin, 1996, p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient, Curr Biol, 6, 1028, 10.1016/S0960-9822(02)00649-8

Hida, 2000, CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling, Immunity, 13, 643, 10.1016/S1074-7613(00)00064-9

Huangfu, 2012, Inflammatory signaling compromises cell responses to interferon alpha, Oncogene, 31, 161, 10.1038/onc.2011.221

Kim, 2015, The immunopathogenesis of psoriasis, Dermatol Clin, 33, 13, 10.1016/j.det.2014.09.002

Kolb-Maurer, 2015, Cutaneous adverse events associated with interferon-beta treatment of multiple sclerosis, Int J Mol Sci, 16, 14951, 10.3390/ijms160714951

Koo, 1999, Current consensus and update on psoriasis therapy: a perspective from the U.S, J Dermatol, 26, 723, 10.1111/j.1346-8138.1999.tb02083.x

Kumar, 2007, Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis, J Cell Biol, 179, 935, 10.1083/jcb.200706034

Kumar, 2004, Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor, J Biol Chem, 279, 46614, 10.1074/jbc.M407082200

Kumar, 2003, SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor, EMBO J, 22, 5480, 10.1093/emboj/cdg524

Kwatra, 2012, JAK Inhibitors in psoriasis: a promising new treatment modality, J Drugs Dermatol, 11, 913

Lichti, 2008, Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice, Nat Protoc, 3, 799, 10.1038/nprot.2008.50

Liu, 2009, Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor, Cell Host Microbe, 5, 72, 10.1016/j.chom.2008.11.008

Lowes, 2007, Pathogenesis and therapy of psoriasis, Nature, 445, 866, 10.1038/nature05663

Messina, 2008, Activated stat-3 in melanoma, Cancer Control, 15, 196, 10.1177/107327480801500302

Nestle, 2005, Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production, J Exp Med, 202, 135, 10.1084/jem.20050500

Peng, 2012, Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice, Sci Transl Med, 4, 118ra11, 10.1126/scitranslmed.3002629

Piehler, 2012, Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation, Immunol Rev, 250, 317, 10.1111/imr.12001

Pines, 2015, Halofuginone—the multifaceted molecule, Molecules, 20, 573, 10.3390/molecules20010573

Platanias, 2005, Mechanisms of type-I- and type-II-interferon-mediated signalling, Nat Rev Immunol, 5, 375, 10.1038/nri1604

Price, 1996, The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light, EMBO J, 15, 6552, 10.1002/j.1460-2075.1996.tb01046.x

Racz, 2011, Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways, J Invest Dermatol, 131, 1547, 10.1038/jid.2011.53

Roth-Cross, 2008, Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia, J Virol, 82, 9829, 10.1128/JVI.01199-08

Tartar, 2014, Update on the immunological mechanism of action behind phototherapy, J Drugs Dermatol, 13, 564

Tas, 2016, Exacerbation of psoriasis induced by interferon-alpha treatment for melanoma, Cutan Ocul Toxicol, 35, 83, 10.3109/15569527.2015.1020545

Ueyama, 2014, Mechanism of pathogenesis of imiquimod-induced skin inflammation in the mouse: a role for interferon-alpha in dendritic cell activation by imiquimod, J Dermatol, 41, 135, 10.1111/1346-8138.12367

Uze, 2007, The receptor of the type I interferon family, Curr Top Microbiol Immunol, 316, 71

van der Fits, 2009, Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis, J Immunol, 182, 5836, 10.4049/jimmunol.0802999

Walters, 2003, Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level, Arch Dermatol, 139, 155, 10.1001/archderm.139.2.155

Wohn, 2013, Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice, Proc Natl Acad Sci USA, 110, 10723, 10.1073/pnas.1307569110

Wong, 2013, Phototherapy in psoriasis: a review of mechanisms of action, J Cutan Med Surg, 17, 6, 10.2310/7750.2012.11124

Zheng, 2011, Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis, Blood, 118, 4003, 10.1182/blood-2011-06-359745