Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

Collaborators, 2019, Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol., 18, 459, 10.1016/S1474-4422(18)30499-X

Zerna, 2018, Current practice and future directions in the diagnosis and acute treatment of ischaemic stroke, Lancet, 392, 1247, 10.1016/S0140-6736(18)31874-9

Sofroniew, 2001, Nerve growth factor signaling, neuroprotection, and neural repair, Annu. Rev. Neurosci., 24, 1217, 10.1146/annurev.neuro.24.1.1217

Rocco, 2018, Nerve Growth Factor: Early Studies and Recent Clinical Trials, Curr. Neuropharmacol., 16, 1455, 10.2174/1570159X16666180412092859

Holtzman, 1996, Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury, Ann. Neurol., 39, 114, 10.1002/ana.410390117

Guégan, 1998, Reduction of cortical infarction and impairment of apoptosis in NGF-transgenic mice subjected to permanent focal ischemia, Brain Res. Mol. Brain Res., 55, 133, 10.1016/S0169-328X(97)00372-0

Saito, 2004, Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor, J. Neurosci., 24, 1584, 10.1523/JNEUROSCI.5209-03.2004

Cao, 2018, Expression of nerve growth factor carried by pseudotyped lentivirus improves neuron survival and cognitive functional recovery of post-ischemia in rats, CNS Neurosci. Ther., 24, 508, 10.1111/cns.12818

Shigeno, 1991, Amelioration of delayed neuronal death in the hippocampus by nerve growth factor, J. Neurosci., 11, 2914, 10.1523/JNEUROSCI.11-09-02914.1991

Rizzi, 2018, NGF steers microglia toward a neuroprotective phenotype, Glia, 66, 1395, 10.1002/glia.23312

Li, 2018, Intranasal administration of nerve growth factor promotes angiogenesis via activation of PI3K/Akt signaling following cerebral infarction in rats, Am. J. Transl. Res., 10, 3481

Zhu, 2011, Intranasal nerve growth factor enhances striatal neurogenesis in adult rats with focal cerebral ischemia, Drug Deliv., 18, 338, 10.3109/10717544.2011.557785

Lee, 1998, Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats, Stroke, 29, 1687, 10.1161/01.STR.29.8.1687

Chiaretti, 2008, Intraventricular nerve growth factor infusion improves cerebral blood flow and stimulates doublecortin expression in two infants with hypoxic-ischemic brain injury, Neurol. Res., 30, 223, 10.1179/016164107X247948

Fantacci, 2013, Neuroprotective role of nerve growth factor in hypoxic-ischemic brain injury, Brain Sci., 3, 1013, 10.3390/brainsci3031013

Aloe, 2012, Nerve growth factor: from the early discoveries to the potential clinical use, J. Transl. Med., 10, 239, 10.1186/1479-5876-10-239

Tria, 1994, Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats, Exp. Neurol., 127, 178, 10.1006/exnr.1994.1093

Pan, 1998, Permeability of the blood-brain barrier to neurotrophins, Brain Res., 788, 87, 10.1016/S0006-8993(97)01525-4

EL Andaloussi, 2013, Extracellular vesicles: biology and emerging therapeutic opportunities, Nat. Rev. Drug Discov., 12, 347, 10.1038/nrd3978

Yang, 2017, Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia, Mol. Ther. Nucleic Acids, 7, 278, 10.1016/j.omtn.2017.04.010

Théry, 2018, Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, J. Extracell. Vesicles, 7, 1535750, 10.1080/20013078.2018.1535750

Valadi, 2007, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat. Cell Biol., 9, 654, 10.1038/ncb1596

Skog, 2008, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nat. Cell Biol., 10, 1470, 10.1038/ncb1800

Li, 2019, In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9, Nano Lett., 19, 19, 10.1021/acs.nanolett.8b02689

Lai, 2015, Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters, Nat. Commun., 6, 7029, 10.1038/ncomms8029

Lai, 2014, Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter, ACS Nano, 8, 483, 10.1021/nn404945r

Yuan, 2017, Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain, Biomaterials, 142, 1, 10.1016/j.biomaterials.2017.07.011

Hu, 2015, Microglial and macrophage polarization—new prospects for brain repair, Nat. Rev. Neurol., 11, 56, 10.1038/nrneurol.2014.207

Tuszynski, 2015, Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease, JAMA Neurol., 72, 1139, 10.1001/jamaneurol.2015.1807

Lin, 2015, Direct hippocampal injection of pseudo lentivirus-delivered nerve growth factor gene rescues the damaged cognitive function after traumatic brain injury in the rat, Biomaterials, 69, 148, 10.1016/j.biomaterials.2015.08.010

Xu, 2019, Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration, Adv. Mater., 31, e1900727, 10.1002/adma.201900727

Houlton, 2019, Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials, Front. Neurosci., 13, 790, 10.3389/fnins.2019.00790

Lapchak, 1993, Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells, Neuroscience, 54, 445, 10.1016/0306-4522(93)90265-H

Thorne, 2001, Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations, Clin. Pharmacokinet., 40, 907, 10.2165/00003088-200140120-00003

Petty, 1994, The effect of systemically administered recombinant human nerve growth factor in healthy human subjects, Ann. Neurol., 36, 244, 10.1002/ana.410360221

Farooqi, 2018, Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds, Biotechnol. Adv., 36, 328, 10.1016/j.biotechadv.2017.12.010

Armstrong, 2017, Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics, ACS Nano, 11, 69, 10.1021/acsnano.6b07607

Sahin, 2014, mRNA-based therapeutics--developing a new class of drugs, Nat. Rev. Drug Discov., 13, 759, 10.1038/nrd4278

Kauffman, 2016, Materials for non-viral intracellular delivery of messenger RNA therapeutics, J. Control. Release, 240, 227, 10.1016/j.jconrel.2015.12.032

Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat. Biotechnol., 29, 341, 10.1038/nbt.1807

Elsharkasy, 2020, Extracellular vesicles as drug delivery systems: Why and how?, Adv. Drug Deliv. Rev., 10.1016/j.addr.2020.04.004

Haney, 2015, Exosomes as drug delivery vehicles for Parkinson’s disease therapy, J. Control. Release, 207, 18, 10.1016/j.jconrel.2015.03.033