Theoretical model for both saturable rate and extent of absorption: Simulations of cefatrizine data

William Couet1, Bruno Reigner2, Jean-Paul Guedes3, Thomas N. Tozer2
1CEMAF, Poitiers, France
2School of Pharmacy, University of California, San Francisco
3Tours – France

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Tài liệu tham khảo

B. G. Reigner, W. Couet, J.-P. Guedes, J. B. Fourtillan, and T. N. Tozer. Saturable rate of absorption of cefatrizine after its oral administration to humans.J. Pharmacokin. Biopharm. 18:17–34 (1990).

T. Kimura, T. Yamamoto, M. Mizuno, Y. Suga, S. Kitade, and H. Sezaki. Characterization of aminocephalosporin transport across rat small intestine.J. Pharmacobiodyn. 6:246–253 (1983).

A. Tsuji, H. Hirooka, T. Terasaki, I. Tamai, and E. Nakashima. Saturable uptake of cefixime, a new oral cephalosporin without an α-amino group, by the rat intestine.J. Pharm. Pharmacol. 39:272–277 (1987).

I. Tamai, H. Y. Ling, S. M. Timbul, J. Nishikido, and A. Tsuji. Stereospecific absorption and degradation of cephalexin.J. Pharm. Pharmacol. 40:320–324 (1988).

P. J. Sinko and G. L. Amidon. Characterization of the oral absorption of β-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestinein situ.Pharm. Res. 5(10):645–650 (1988).

T. Yoshikawa, N. Muranushi, M. Yoshida, T. Oguma, K. Hirano, and H. Yamada. Transport characteristics of ceftibuten (7432-S), a new oral cephem, in rat intestinal brush-border membrane vesicles: proton-coupled and stereoselective transport of ceftibuten.Pharm. Res. 6(4):302–307 (1989).

N. Muranushi, T. Yoshikawa, M. Yoshida, T. Oguma, K. Hirano, and H. Yamada. Transport characteristics of ceftibuten, a new oral cephem, in rat intestinal brush-border membrane vesicles: relationship to oligopeptide and amino-β-lactam transport.Pharm. Res. 6(4):308–312 (1989).

M. Pfeffer, R. C. Gaver, and J. Ximenez. Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizine.Antimicrob. Agents. Chemother. 24:915–920 (1983).

J. Sjövall, G. A. Alvan, and D. Wsterlund. Dose-dependent absorption of amoxycillin and bacampicillin.Clin. Pharmacol. Ther. 38:241–250 (1985).

P. J. Sinko and G. L. Amidon. Characterization of the oral absorption of β-lactam antibiotics. II: Competitive absorption and peptide transport specificity.J. Pharm. Sci. 78:723–727 (1989).

A. Sánchez-Picó, J. E. Peris-Ribera, C. Toledano, F. Torres-Molina, V. G. Casabó, A. Martin-Villodre, and J. M. Plá-Delfina. Non-linear intestinal absorption kinetics of cefadroxil in the rat.J. Pharm. Pharmacol. 41:179–185 (1989).

Statistical Consultants, PCNONLIN and NONLIN 84. Software for the statistical analysis of nonlinear models. TheAm. Statist. 40:52 (1986).

R. C. Gaver and G. Deeb. Disposition of14C-cefatrizine in man.Drug Metab. Dispos. 8:157–162 (1980).

M. Rowland and T. N. Tozer.Clinical Pharmacokinetics: concepts and Applications, 2nd ed., Lea & Febiger, Philadelphia, 1989, pp. 480–481.

G. D. Leesman, P. J. Sinko, and G. L. Amidon. simulation of oral drug absorption: Gastric emptying and gastrointestinal motility. In P. G. Welling (ed.),Pharmacokinetics: Regulatory Industrial Academic perspectives, Marcel Dekker, New York, 1988, pp. 267–284.

G. M. Grass and W. T. Morehead. Evidence for site-specific absorption of a novel ACE inhibitor.Pharm. Res. 6:759–765 (1989).